Perinatal exposure to morphine: reactive changes in the brain after 6-hydroxydopamine.
Eur J Pharmacol
; 303(1-2): 21-6, 1996 May 06.
Article
em En
| MEDLINE
| ID: mdl-8804907
ABSTRACT
The effects of neonatal 6-hydroxydopamine treatment on the brain of control rats and of rats perinatally exposed to morphine were examined. Noradrenaline levels were increased in the pons-medulla, mesencephalon and caudate of 8-week-old control rats lesioned with neonatal 6-hydroxydopamine; perinatal morphine treatment prevented such an increase. In the caudate, there was a loss of dopamine and an increase of serotonin following the neurotoxic lesion; exposure to perinatal morphine prevented the serotonin increase. Brain expression of synapsin I mRNA was particularly abundant in cerebral cortex, hippocampus, dentate gyrus and olfactory bulb. In perinatal morphine-treated rats, the expression of synapsin I mRNA was significantly reduced; interestingly, the neonatal treatment with 6-hydroxydopamine normalized its expression. Therefore, brain-reactive neurochemical changes triggered by 6-hydroxydopamine were suppressed by perinatal morphine exposure whereas the association of morphine exposure and 6-hydroxydopamine lesion promoted the normal mRNA expression of the synaptic marker synapsin I.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Efeitos Tardios da Exposição Pré-Natal
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Encéfalo
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Norepinefrina
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Oxidopamina
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Adrenérgicos
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Morfina
Limite:
Animals
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Pregnancy
Idioma:
En
Revista:
Eur J Pharmacol
Ano de publicação:
1996
Tipo de documento:
Article
País de afiliação:
Itália