Hyperresponsive B cells in CD22-deficient mice.
Science
; 274(5288): 798-801, 1996 Nov 01.
Article
em En
| MEDLINE
| ID: mdl-8864124
ABSTRACT
CD22 is a surface glycoprotein of B lymphocytes that is rapidly phosphorylated on cytoplasmic tyrosines after antigen receptor cross-linking. Splenic B cells from mice with a disrupted CD22 gene were found to be hyperresponsive to receptor signaling Heightened calcium fluxes and cell proliferation were obtained at lower ligand concentrations. The mice gave an augmented immune response, had an expanded peritoneal B-1 cell population, and contained increased serum titers of autoantibody. Thus, CD22 is a negative regulator of antigen receptor signaling whose onset of expression at the mature B cell stage may serve to raise the antigen concentration threshold required for B cell triggering.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Linfócitos B
/
Antígenos de Diferenciação de Linfócitos B
/
Antígenos CD
/
Moléculas de Adesão Celular
/
Lectinas
Limite:
Animals
Idioma:
En
Revista:
Science
Ano de publicação:
1996
Tipo de documento:
Article
País de afiliação:
Reino Unido