The developmental pattern of somatostatin in the embryonic and fetal rat pancreas.
Endocrinology
; 101(3): 825-9, 1977 Sep.
Article
em En
| MEDLINE
| ID: mdl-891466
ABSTRACT
The ontogenesis of immunoreactive somatostatin in the embryonic and fetal rat pancreas has been measured by radioimmunoassay following acid extraction. Somatostatin (GIF) is detectable at 14 days gestation at a concentration of 1.6 X 10(-3) ng/pancreas. At term the content is 3.8 ng/pancreas, by 2 days neonatally, 8.3 ng/pancreas, and in the adult rat, 71 ng/pancreas through the concentration (expressed per microgram DNA) is constant from 14-19 days of gestation and reaches a level characteristic of the fully differentiated pancreas by birth. The detection of GIF in cultured pancreatic explants in the absence of innervation indicates that synthesis can occur independent of neural influence.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Pâncreas
/
Somatostatina
Limite:
Animals
/
Pregnancy
Idioma:
En
Revista:
Endocrinology
Ano de publicação:
1977
Tipo de documento:
Article