Nuclear architecture and the induction of chromosomal aberrations.
Mutat Res
; 366(2): 97-116, 1996 Nov.
Article
em En
| MEDLINE
| ID: mdl-9001577
ABSTRACT
Progress in fluorescence in situ hybridization, three dimensional microscopy and image analysis has provided the means to study the three-dimensional structure and distribution of chromosome territories within the cell nucleus. In this contribution, we summarize the present state of knowledge of the territorial organization of interphase chromosomes and their topological relationships with other macromolecular domains in the human cell nucleus, and present data from computer simulations of chromosome territory distributions. On this basis, we discuss models of chromosome territory and nuclear architecture and topological consequences for the formation of chromosome exchanges.
Buscar no Google
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Núcleo Celular
/
Aberrações Cromossômicas
Limite:
Animals
/
Female
/
Humans
/
Male
Idioma:
En
Revista:
Mutat Res
Ano de publicação:
1996
Tipo de documento:
Article
País de afiliação:
Alemanha