Activity of compounds isolated from Chilean lichens against experimental cutaneous leishmaniasis.
Comp Biochem Physiol C Pharmacol Toxicol Endocrinol
; 116(1): 51-4, 1997 Jan.
Article
em En
| MEDLINE
| ID: mdl-9080673
ABSTRACT
Three secondary metabolites isolated from Chilean lichens, (+) usnic acid, pannarine and 1'-chloropannarine, were tested against promastigotes forms of three strains of Leishmania ssp. Pannarine and 1'-chloropannarine exhibited in vitro activity at 50 micrograms/ml and (+) usnic acid at 25 micrograms/ml. BALB/c mice infected with Leishmania amazonensis were treated 4 weeks post-infection with (+) usnic acid by subcutaneous or oral routes for 15 days at 25 mg/kg or by five intralesional injections at interval of 4 days at 25 mg/kg of body weight. The reference drug, N-methylglucamine antimonate (Glucantime), was administered by subcutaneous injections (regimens of 28 mg of pentavalent antimony) for 15 days. The subcutaneous and oral treatments with (+) usnic did not produce any effect, but by intralesional administration we observed a significant effect that reduced by 43.34% the weight lesions and by 72.28% the parasites loads in infected footpads.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Benzofuranos
/
Benzoxepinas
/
Leishmaniose Cutânea
/
Líquens
/
Antiprotozoários
Limite:
Animals
País/Região como assunto:
America do sul
/
Chile
Idioma:
En
Revista:
Comp Biochem Physiol C Pharmacol Toxicol Endocrinol
Assunto da revista:
ENDOCRINOLOGIA
/
FARMACOLOGIA
/
TOXICOLOGIA
Ano de publicação:
1997
Tipo de documento:
Article
País de afiliação:
Paraguai