Effects of sex and MK-801 on auditory-processing deficits associated with developmental microgyric lesions in rats.
Behav Neurosci
; 111(2): 404-12, 1997 Apr.
Article
em En
| MEDLINE
| ID: mdl-9106679
ABSTRACT
Neonatally induced microgyric lesions produce defects in rapid auditory processing in adult male rats. Given that females across species are less susceptible to the deleterious effects of neural injury and that treatment with neuroprotective agents at the time of injury can reduce neural damage, the authors tested the effects of sex and neuroprotectant exposure on the behavioral consequences of microgyric lesions in rats. Results showed that sham but not microgyric males were able to perform the task at the fastest rate of stimulus presentation. Microgyric females, in contrast, discriminated at all stimulus conditions and did not differ from female shams. Microgyric males treated with MK-801 had reduced cortical damage and performed the discrimination at the fastest condition. Results suggest that females are less susceptible to the behavioral effects of neocortical microgyria and that MK-801 may ameliorate the behavioral consequences of these lesions in male rats.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Tempo de Reação
/
Atenção
/
Diferenciação Sexual
/
Percepção Auditiva
/
Córtex Cerebral
/
Maleato de Dizocilpina
/
Fármacos Neuroprotetores
Tipo de estudo:
Risk_factors_studies
Limite:
Animals
/
Pregnancy
Idioma:
En
Revista:
Behav Neurosci
Ano de publicação:
1997
Tipo de documento:
Article
País de afiliação:
Estados Unidos