Pentoxifylline decreases brain levels of platelet activating factor in murine AIDS.
Eur J Pharmacol
; 325(1): 81-4, 1997 Apr 23.
Article
em En
| MEDLINE
| ID: mdl-9151942
ABSTRACT
Tumor necrosis factor-alpha (TNF-alpha) and platelet-activating factor (PAF) have been implicated in the pathogenesis of human immunodeficiency virus (HIV)-associated encephalopathy. The effects of pentoxifylline on brain PAF levels were examined in mice infected with the LP-BM5 murine leukemia virus (MuLV). Seven weeks after viral inoculation, significant increases in serum TNF-alpha and brain PAF levels were observed. One week of treatment with pentoxifylline initiated 6 weeks postinfection significantly reduced both serum TNF-alpha and brain PAF levels. A significant positive correlation was observed between the levels of these substances (r = 0.62; P < 0.01). This study demonstrates that pentoxifylline treatment was effective in decreasing the levels of TNF-alpha in the serum and PAF levels in the brain of mice infected with the LP-BM5 MuLV.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Pentoxifilina
/
Inibidores de Fosfodiesterase
/
Encéfalo
/
Encefalopatias
/
Fator de Ativação de Plaquetas
/
Síndrome de Imunodeficiência Adquirida Murina
Limite:
Animals
Idioma:
En
Revista:
Eur J Pharmacol
Ano de publicação:
1997
Tipo de documento:
Article
País de afiliação:
Estados Unidos