No association between the alpha 1-antichymotrypsin A allele and Alzheimer's disease.
Neurology
; 48(5): 1313-6, 1997 May.
Article
em En
| MEDLINE
| ID: mdl-9153464
ABSTRACT
The alpha 1-antichymotrypsin (ACT) A allele was recently associated with Alzheimer's disease (AD), and the ACT AA genotype was reported to be more frequent in AD subjects with the apolipoprotein E (APOE) epsilon4 allele. We examined ACT and APOE genotypes in a sample of 160 subjects with probable AD and in 102 elderly control subjects. ACT A allele frequencies were similar in AD subjects (0.503) and elderly controls (0.519). In addition, we found no evidence that in AD the AA genotype is more frequent in subjects with the APOE epsilon4 allele than in those without it. Our results do not support an association between the ACT A allele and AD.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Alfa 1-Antiquimotripsina
/
Alelos
/
Doença de Alzheimer
Tipo de estudo:
Risk_factors_studies
Limite:
Adult
/
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Neurology
Ano de publicação:
1997
Tipo de documento:
Article
País de afiliação:
Estados Unidos