Sequential roles of agrin, MuSK and rapsyn during neuromuscular junction formation.
Curr Opin Neurobiol
; 7(3): 379-84, 1997 Jun.
Article
em En
| MEDLINE
| ID: mdl-9232805
ABSTRACT
Formation of the neuromuscular junction requires a series of reciprocal inductive interactions between the motor neuron and the muscle cell that culminate in the precise juxtaposition of a highly specialized presynaptic nerve terminal with a complex postsynaptic endplate on the muscle surface. Although nerve-derived agrin has long been thought to play a key role during neuromuscular junction formation, the molecular mechanisms underlying its actions are only now coming into focus, following the recent discovery that agrin acts via the MuSK receptor tyrosine kinase.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Receptores Nicotínicos
/
Agrina
/
Proteínas Musculares
/
Junção Neuromuscular
Limite:
Animals
Idioma:
En
Revista:
Curr Opin Neurobiol
Assunto da revista:
BIOLOGIA
/
NEUROLOGIA
Ano de publicação:
1997
Tipo de documento:
Article
País de afiliação:
Estados Unidos