Analysis of benzalkonium chloride in the effluent from European hospitals by solid-phase extraction and high-performance liquid chromatography with post-column ion-pairing and fluorescence detection.
J Chromatogr A
; 774(1-2): 281-6, 1997 Jul 11.
Article
em En
| MEDLINE
| ID: mdl-9253191
ABSTRACT
A highly reproducible and specific method for the analysis of the quaternary ammonium compound, benzalkonium chloride, in effluents from European hospitals is presented. Benzalkonium chloride was extracted with end-capped RP-18 solid-phase cartridges and was selectively eluted. The resulting solution was analyzed by high-performance liquid chromatography (HPLC). After elution from the analytical column of the HPLC system, 9,10-dimethoxyanthracene-2-sulfonate was added continuously as a fluorescence marker, forming a hydrophobic ion-pair with benzalkonium chloride. The ion-pair was analyzed by fluorescence detection. The method was applied to highly complex effluent samples from different sized European hospitals. The measured concentrations were between 0.05 and 6.03 mg/l. The amounts emitted per bed and year were 4.5-362 g and did not correlate with the size of the hospital. The total amounts were 2.6-909 kg/year.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Esgotos
/
Compostos de Benzalcônio
/
Cromatografia Líquida de Alta Pressão
/
Hospitais
Tipo de estudo:
Diagnostic_studies
País/Região como assunto:
Europa
Idioma:
En
Revista:
J Chromatogr A
Ano de publicação:
1997
Tipo de documento:
Article
País de afiliação:
Alemanha