Altered catecholamine synthesis and degradation in the epidermis of patients with atopic eczema.
Arch Dermatol Res
; 289(12): 663-6, 1997 Nov.
Article
em En
| MEDLINE
| ID: mdl-9452885
ABSTRACT
Patients with atopic eczema have significantly higher norepinephrine levels in plasma than healthy controls. In addition, significantly higher levels of the essential cofactor (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin (6BH4) were found in this patient group. Cell extracts from epidermal suction blister roofs revealed only half the normal activity of phenylethanolamine-N-methyl transferase (PNMT) together with a threefold induction of the norepinephrine-degrading enzyme monoamine oxidase A (MAO-A). Taken together, these results support earlier observations of a defective catecholamine/adrenoceptor signal in patients with atopic eczema.
Buscar no Google
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Catecolaminas
/
Receptores Adrenérgicos beta 2
/
Dermatite Atópica
/
Epiderme
Tipo de estudo:
Observational_studies
Limite:
Adolescent
/
Adult
/
Child
/
Female
/
Humans
/
Male
Idioma:
En
Revista:
Arch Dermatol Res
Ano de publicação:
1997
Tipo de documento:
Article
País de afiliação:
Reino Unido