Congenital defects in newborn foals of mares treated for equine protozoal myeloencephalitis during pregnancy.
J Am Vet Med Assoc
; 212(5): 697-701, 1998 Mar 01.
Article
em En
| MEDLINE
| ID: mdl-9524643
ABSTRACT
Three weak, recumbent neonatal foals with skin lesions, including a thin wooly coat, were born to mares being treated for equine protozoal myeloencephalitis. Mares received sulfadiazine or sulfamethoxazole-trimethoprim, pyrimethamine, folic acid, and vitamin E orally. Foals were anemic, leukopenic, azotemic, hyponatremic, and hyperkalemic. Serum folate concentrations in the 3 foals and 2 mares were lower than those reported in the literature for clinically normal brood mares. Treatment was unsuccessful. For each foal, necropsy revealed lobulated kidneys with thin cortices and a pale medulla, and the spleen and thymus were small. Histologic examination revealed marked epidermal necrosis without inflammatory cells, thin renal cortices, renal tubular nephrosis, lymphoid aplasia, and bone marrow aplasia and hypoplasia. These observations indicate that oral administration of sulfonamides, 2,4-diaminopyrimidines (pyrimethamine with or without trimethoprim), and folic acid to mares during pregnancy is related to congenital defects in newborn foals.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Infecções Protozoárias em Animais
/
Complicações Parasitárias na Gravidez
/
Encefalomielite
/
Ácido Fólico
/
Antagonistas do Ácido Fólico
/
Cavalos
/
Animais Recém-Nascidos
Tipo de estudo:
Etiology_studies
Limite:
Animals
/
Pregnancy
Idioma:
En
Revista:
J Am Vet Med Assoc
Ano de publicação:
1998
Tipo de documento:
Article
País de afiliação:
Estados Unidos