Combined pulmonary toxicity of diethyldithiocarbamate and lead (II) oxide in rats.
J Appl Toxicol
; 18(1): 33-7, 1998.
Article
em En
| MEDLINE
| ID: mdl-9526832
ABSTRACT
The pulmonary toxicity of sodium diethyldithiocarbamate and lead(II) oxide alone or in combination was studied in rats after a single intratracheal instillation. The lead content in the lungs and the whole blood was determined and it has been found that the clearance of lead from the lung was delayed by dithiocarbamate complex formation, which probably had a role in increased IgA levels in the bronchoalveolar fluid and the induction of local immune response. The combined exposure gave rise to calcium deposits in the lungs both extra- and intracellularly after 1 month of exposure. Both separate and combined exposure invoked permanent injury in membranes or dystrophic changes in the cytoplasm of pneumocytes, which may initiate and generate a series of events leading to fibrosing alveolitis.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Óxidos
/
Adjuvantes Imunológicos
/
Ditiocarb
/
Chumbo
/
Pulmão
Limite:
Animals
Idioma:
En
Revista:
J Appl Toxicol
Ano de publicação:
1998
Tipo de documento:
Article
País de afiliação:
Hungria