[Mutagenic effect of small doses of diethylsulfate in laboratory mice studied by specific locus method]. / Issledovanie mutagennogo effekta malykh doz diétilsul'fata u laboratornykh myshei metodom opredelennykh lokusov
Genetika
; 12(3): 163-5, 1976.
Article
em Ru
| MEDLINE
| ID: mdl-955407
ABSTRACT
Diethylsulphate solution was injected intraperitoneally twice a week to male mice B10.C3H having the wild-type colour at a 5 mg/kg dose. The treatment lasted 10 weeks, so that the total dose administered was 5-20 = 100 mg/kg. In fifth week after the end of the treatment these males were crossed to YT females homozygous for seven recessive mutant genes. In the control group all the F1 descendants were of wild-type colour, while in the experimental group among 5042 F1 mice derived from DES-treated spermatogonia there was one mutant d and 4 mosaics (3 with respect to the locus c and 1 with respect to the locusa). These results are interpreted as the evidence of the mutagenic effect of DES.
Buscar no Google
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Ácidos Sulfúricos
/
Etano
/
Mutagênicos
Limite:
Animals
Idioma:
Ru
Revista:
Genetika
Ano de publicação:
1976
Tipo de documento:
Article