Alpha interferon treatment in myasthenia gravis: effects on natural killer cell activity.
J Neuroimmunol
; 82(2): 109-15, 1998 Mar 01.
Article
em En
| MEDLINE
| ID: mdl-9585806
ABSTRACT
The efficacy of recombinant interferon-alpha (rIFN alpha), on natural killer (NK) cell cytotoxic activity, CD3+, CD4+, CD8+, CD56+, HLA-DR+ lymphocyte counts, anti-acetylcholine receptor antibody (AChR Ab) levels, single fibre electromyography findings (SFEMG) and clinical course were evaluated in patients with myasthenia gravis (MG). During the IFN alpha treatment (3 mu, subcutaneous, 3 times a week), NK cell cytotoxicity and CD4+/8+ ratio increased, NK cell count remarkably decreased, and no significant clinical or SFEMG changes were observed. This preliminary open study in MG patients has demonstrated enhanced NK activity per unit NK cell after IFN alpha therapy. Although lymphocyte phenotypes and NK function approached normal levels during therapy, a higher dose of IFN alpha may be required for a significant clinical response. It has been also concluded that 6 months of IFN alpha therapy seems to be safe in MG, though in patients with malignancy, IFN alpha may cause increased autoimmunity, AChR positivity and MG.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Células Matadoras Naturais
/
Interferon-alfa
/
Miastenia Gravis
Limite:
Adult
/
Female
/
Humans
/
Male
Idioma:
En
Revista:
J Neuroimmunol
Ano de publicação:
1998
Tipo de documento:
Article
País de afiliação:
Turquia