Dopamine receptor mRNAs in the rat lymphocytes.
Life Sci
; 62(21): 1919-25, 1998.
Article
em En
| MEDLINE
| ID: mdl-9619840
ABSTRACT
It has been suggested that dopamine might play a role in the regulation of the immune system. In this study, reverse transcriptase-polymerase chain reaction (RT-PCR) was used to investigate the expression of mRNA for the different subtypes of dopamine receptors in the rat lymphocytes. D1, D3 and D5 receptor mRNAs were identified. These results provide further evidence for the interaction of dopamine systems and the immune system, and suggest to further investigate whether the immunosuppressive actions of dopamine and dopaminergic drugs might depend on a direct interaction with dopamine receptors on the lymphocyte membrane. Moreover, they suggest the suitability of this animal species to further investigate the correlation between changes in the expression of central and peripheral dopamine receptors produced by manipulations of the dopamine systems.
Buscar no Google
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
RNA Mensageiro
/
Linfócitos
/
Receptores Dopaminérgicos
Limite:
Animals
Idioma:
En
Revista:
Life Sci
Ano de publicação:
1998
Tipo de documento:
Article
País de afiliação:
Itália