Reversible symmetric polyneuropathy with paraplegia after heart transplantation.
Transplantation
; 65(10): 1394-5, 1998 May 27.
Article
em En
| MEDLINE
| ID: mdl-9625024
ABSTRACT
BACKGROUND:
Neurotoxicity is a well-recognized side effect of cyclosporine therapy in transplant recipients. Cyclosporine can cause a wide range of adverse effects on both the central and peripheral nervous systems.METHODS:
We present a case history of symmetric polyneuropathy with flaccid paraplegia, a rare neurological complication of cyclosporine administration.RESULTS:
Blood levels of the drug above the therapeutic range accompanied the neurological manifestations. The syndrome subsided fully with dose reduction. Patients' symptoms were attributed to axonal degeneration of the peripheral nerves, according to electromyography findings.CONCLUSIONS:
Cyclosporine neurotoxicity should always be considered in patients with neurological complications following transplantation. The case presented in this article illustrates an additional potential mechanism of this adverse effect, namely, axonal degeneration of the peripheral nerves, causing symmetric polyneuropathy.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Paraplegia
/
Complicações Pós-Operatórias
/
Transplante de Coração
/
Ciclosporina
/
Doenças do Sistema Nervoso Periférico
/
Imunossupressores
Tipo de estudo:
Diagnostic_studies
Limite:
Female
/
Humans
/
Middle aged
Idioma:
En
Revista:
Transplantation
Ano de publicação:
1998
Tipo de documento:
Article
País de afiliação:
Grécia