Lack of susceptibility of Ehrlichia canis to imidocarb dipropionate in vitro.
J S Afr Vet Assoc
; 69(2): 55-6, 1998 Jun.
Article
em En
| MEDLINE
| ID: mdl-9760397
ABSTRACT
In vitro antimicrobial susceptibility testing was used to compare the efficacy of imidocarb dipropionate and doxycycline on the growth of Ehrlichia canis in DH82 cell cultures. Over a 9-day period there were no significant differences (p < 0.01) in the growth of E. canis in untreated control wells and those to which imidocarb dipropionate was added at 1.2, 2.4, 4.8 or 12 micrograms/ml for the 1st 3 days. Average infection rates rose from 50 to 55% on day 0 to 100% on day 5 or 6. Doxycycline at 1 microgram/ml had residual or rickettsiocidal activity against E. canis with the average percentages of DH82 cells infected declining from 51 to 24% while the organism was exposed to the drug (3 days) and from 21 to 2% in the 6 days following removal of the drug from the cell culture medium.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Ehrlichia
/
Imidocarbo
/
Antibacterianos
Limite:
Animals
Idioma:
En
Revista:
J S Afr Vet Assoc
Ano de publicação:
1998
Tipo de documento:
Article
País de afiliação:
Zimbábue