Active and passive immunization against HIV type 1 infection in chimpanzees.
AIDS Res Hum Retroviruses
; 14 Suppl 3: S271-6, 1998 Oct.
Article
em En
| MEDLINE
| ID: mdl-9814955
ABSTRACT
Several vaccine strategies have been developed to prevent primary infection with human immunodeficiency virus (HIV), and some of the candidate vaccines have been tested in chimpanzees to determine their safety, efficacy, and to delineate immune correlates of protection. To date, more than 25 vaccines representing active and passive immunization strategies have been evaluated in the chimpanzee model. Efficacy of a given vaccine was based on protection against primary infection with HIV after intravenous or mucosal challenge with cell-free or cell-associated virus. Based on the results from a majority of the studies, neutralizing antibodies appear to play a major role in preventing primary infection with HIV.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Infecções por HIV
/
Imunização Passiva
/
Vacinação
Limite:
Animals
Idioma:
En
Revista:
AIDS Res Hum Retroviruses
Assunto da revista:
SINDROME DA IMUNODEFICIENCIA ADQUIRIDA (AIDS)
Ano de publicação:
1998
Tipo de documento:
Article
País de afiliação:
Estados Unidos