Clonazepam release from poly(DL-lactide-co-glycolide) nanoparticles prepared by dialysis method.
Arch Pharm Res
; 21(4): 418-22, 1998 Aug.
Article
em En
| MEDLINE
| ID: mdl-9875469
ABSTRACT
Aim of this work is to prepare poly(DL-lactide-co-glycolide) (PLGA) nanoparticles by dialysis method without surfactant and to investigate drug loading capacity and drug release. The size of PLGA nanoparticles was 269.9 +/- 118.7 nm in intensity average and the morphology of PLGA nanoparticles was spherical shape from the observation of SEM and TEM. In the effect of drug loading contents on the particle size distribution, PLGA nanoparticles were monomodal pattern with narrow size distribution in the empty and lower drug loading nanoparticles whereas bi- or trimodal pattern was showed in the higher drug loading ones. Release of clonazepam from PLGA nanoparticles with higher drug loading contents was slower than that with lower loading contents.
Buscar no Google
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Ácido Poliglicólico
/
Polímeros
/
Clonazepam
/
Ácido Láctico
Idioma:
En
Revista:
Arch Pharm Res
Ano de publicação:
1998
Tipo de documento:
Article