Validation of the 7th AJCC/UICC staging system for gastric cancer and a proposal for a new TNM system based on a prognostic score: a retrospective multicenter study
Annals of Surgical Treatment and Research
; : 295-302, 2016.
Article
em En
| WPRIM
| ID: wpr-89527
Biblioteca responsável:
WPRO
ABSTRACT
PURPOSE:
We validate the 7th American Joint Committee on Cancer/Union for International Cancer Control (AJCC/UICC) staging system for gastric cancer and propose a new staging system that reflects the prognostic significances of each of T and N category.METHODS:
Data from 5,957 patients who underwent curative gastrectomies from 2000 to 2007 at 4 university hospitals in Daegu Metropolitan city in Korea were analyzed for the validation of the 7th AJCC/UICC staging system for gastric cancer. The hazard ratios of the respective T and N categories were estimated and converted to weightings and summated to make prognostic score (P-score). Homogeneity and stage grouping were determined according to the P-scores.RESULTS:
In the 7th AJCC/UICC staging system for gastric cancer, poor discrimination was noted between stages IIB and IIIA (P = 0.152). In addition, heterogeneity in stage IIB (P = 0.021) and a small gap in 5-year survival rates (1.7%) between stages IA and IB were noted. A new proposed staging system was generated on the basis of P-scores and demonstrated more discrimination between stages and more homogeneity within stages. The new staging system reflects the different prognostic impacts of N3a and N3b.CONCLUSION:
Several controversial issues of the 7th AJCC/UICC staging system for gastric cancer were reconfirmed in the present analysis. The TNM system based on P-score appears to be more scientifically accurate than the 7th AJCC/UICC staging system for gastric cancer.Palavras-chave
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Base de dados:
WPRIM
Assunto principal:
Neoplasias Gástricas
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Características da População
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Taxa de Sobrevida
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Estudos Retrospectivos
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Discriminação Psicológica
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Gastrectomia
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Hospitais Universitários
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Articulações
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Coreia (Geográfico)
Tipo de estudo:
Observational_studies
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Prognostic_studies
Limite:
Humans
País/Região como assunto:
Asia
Idioma:
En
Revista:
Annals of Surgical Treatment and Research
Ano de publicação:
2016
Tipo de documento:
Article