Ultrasound-guided external jugular vein cannulation for central venous access by inexperienced trainees.

BACKGROUND AND OBJECTIVE: The insertion of central venous catheters via the external jugular vein (EJV) is not always practical because of the relatively frequent failure rate; thus, the internal jugular approach is generally used. Data from the literature suggest that ultrasound-guided catheterization of the internal jugular vein is superior to the surface anatomy landmark technique and, therefore, should be the method of choice. We evaluated the value of ultrasound guidance in the learning process of central venous cannulation via EJV by similarly inexperienced trainees. METHODS: In this prospective randomized study, 60 patients were assigned to two groups: group SA (surface anatomy; n = 30) underwent insertion of the central venous catheter using landmark guidance and group US (ultrasound; n = 30) underwent insertion using ultrasound guidance. In all patients, catheter insertion through the right EJV was performed by trainees in their second year of training. Ultrasound guidance was carried out by the same ultrasound specialist. The following parameters were evaluated in all patients: the number of successful punctures of the right EJV, the total number of attempts and the time to vein puncture; the number of successful insertions of the central venous catheter, the number of attempts and the duration of catheterization (from puncture of EJV to external fixation of the catheter); and the incidence of complications. The study was approved by the institutional ethics committee, and all patients gave written informed consent. Data were expressed as mean +/- SD. Student's t-test, Mann-Whitney test and chi2-test were used for analysis and P < 0.05 was considered statistically significant. The power of the study was 85%. RESULTS: The EJV puncture was successful in 24 out of 30 (80%) patients from group SA and in 22 out of 30 (73%) patients from group US (P = NS). There were no statistically significant differences between the groups regarding the mean time to perform the vein puncture and the number of attempts. The insertion of the central venous catheter was performed successfully in 10 (33%) patients from group SA and six (20%) patients from group US. The success rate of central cannulation via the EJV approach was 10 out of 24 (42%) in group SA and six out of 22 (27%) in group US (P = NS). The total time for insertion and the number of attempts were similar in both groups (P = NS). Local haematoma occurred in 11 patients in group SA and in three patients in group US (P = NS). CONCLUSION: Our results demonstrate no significant differences between the conventional surface anatomy landmark technique and the ultrasound-guided technique for the insertion of a central venous catheter via EJV by inexperienced trainees.

Nicotine patch for the prevention of postoperative nausea and vomiting: a prospective randomised trial.

BACKGROUND AND OBJECTIVE: It has been demonstrated that smoking significantly reduces postoperative nausea and vomiting (PONV). However, there are approximately 4000 substances in cigarette smoke that can be responsible for this effect. To demonstrate whether nicotine is the substance with antiemetic effects we applied a nicotine patch in patients undergoing laparoscopic cholecystectomy under general anaesthesia. METHODS: Seventy-five patients classified as ASA (American Society of Anesthesiologists' classification) I/II were divided in three groups: group 1 (n = 25), which comprised non-smokers; group 2 (n = 25), which comprised patients who had given up smoking for the last 5 years and received perioperatively a nicotine patch that contained 16.6mg nicotine/patch; and group 3 (n = 25), which comprised actual smokers. Postoperatively, the incidence of PONV and the need for antiemetic rescue medication were monitored every 6 hours. RESULTS: We found a significant reduction in the incidence of PONV in group 2 (5/25 [20%], p = 0.0001 vs group 1) and group 3 (8/25 [32%], p = 0.002 vs group 1) compared with group 1 (18/25 [76%]). The difference in incidence of PONV between group 2 and group 3 was not significant (p > 0.05). CONCLUSIONS: Nicotine significantly reduced the incidence of PONV after laparoscopic cholecystectomy.

The public perception of the anaesthesiologist in Romania: a survey.

BACKGROUND: Previous studies have shown that the public perception of anaesthesiologists' duties regarding perioperative management lacks a good understanding. The aim of this study was to assess the public perception of the anaesthesiologist's role before, during and after surgery, in Romania. METHOD: The prospective cross-sectional study was undertaken between January 2015 and August 2016. A questionnaire that comprised 23 questions was uploaded on Google at https://docs.google.com/forms/d/1KxC8jSYydhEu3pn0Hr0LHEsuCEQLSEHQqUo_HzrHuw8/viewform. The link was forwarded on-line randomly (mail, social media). The questions were structured based on current literature. Inclusion criteria were people aged >15 years and not directly related to any medical activity. The answers were anonymously registered, in real time, in an Excel format, used later to process the statistics. RESULTS: 1153 people completed the questionnaire, 61% female and 39% male, 80.8% being from the urban area and 19.2% from the countryside. 62.7% were hospitalized in the past, and 49.8% had undergone at least one surgery. From the questioned group 65.2% had graduated university, and 64.3% were aged between 20 and 40 years. A majority of 1089 respondents (94.6%) knew that the anaesthesiologist was responsible for providing anaesthesia in the operating room. 26.6% considered that the surgeon and the anaesthesiologist played different roles in OR, but 54.4% understood that there is a collaboration between them during surgery. Only 36.2% were aware that the anaesthesiologist replaces blood losses and provides patients hemodynamic stability and proper oxygenation during surgery. 54.6% believe that the surgeon decides upon the postoperative pain management and only 32% know the anaesthesiologist is the physician in charge of intensive care patients. 79.5% of respondents are willing to receive from their anaesthesiologist detailed information, regarding anaesthesia and postoperative care, before surgery, and consider that more publicity should be made regarding this profession. CONCLUSION: The public perception of the anaesthesiologist's role in Romania is inaccurate in spite of the fact that a large group in our study comprised highly educated people living in urban areas. We consider that further strengthening of the anaesthesiologist/patient relationship and an increased media exposure of our specialty would help to improve its social perception.

Perioperative application of the Viscum album extract Isorel in digestive tract cancer patients.

BACKGROUND: It is assumed that perioperative immunomodulation of cancer patients can attenuate cellular and humoral deficiencies thus improving their overall health status. Mistletoe (Viscum album L.) anticancer drugs are likely candidates for such adjuvant therapy, because they do not have major adverse side-effects but have dual desirable activities; immune-modulating effects and relatively selective cytotoxicity for cancer cells. MATERIALS AND METHODS: We used the aqueous extract Isorel, which is produced from the entire plant and is validated for batch consistency. The study involved 70 cancer patients, divided into two groups: Isorel-treated group of 40 patients who received Isorel for 2 pre- and 2 post-operative weeks (1 esophageal, 16 gastric, 2 pancreatic and 21 colorectal carcinomas) and the age- and sex-matched control group of 30 patients that did not receive Isorel (2 esophageal, 9 gastric, 3 pancreatic, 1 ileac and 15 colorectal carcinomas). Blood samples were obtained to study parameters of the immune system before the surgery and the drug administration (DO) and on the postoperative days 1 and 14 (D1, D14). The overall health status was evaluated after 60 days by the Kamofsky Performance Index and by the Analogic Scale of Anxiety. The results were compared by Student's t-test and one-way ANOVA test. RESULTS: Isorel significantly attenuated the immuno-suppressive effects of surgery observed for the Isorel-treated group, increasing the number of NK cells, the T and B cells, in particular T-helper cells, complement, IgA, IgG and IgM values also in comparison to the respective D0 values. Both the Kamofsky status and the Anxiety Scale improved remarkably in Isorel-treated patients in comparison to the control. CONCLUSION: The results of this study indicate that perioperative use of the mistletoe drug Isorel can improve immune competence and the overall health status of cancer patients undergoing surgery.

Radiofrequency by open surgical approach in the treatment of hepatic tumours: early experience with 14 cases.

The aim of the study was the evaluation of radiofrequency in the treatment of hepatic tumours during laparotomy performed for hepatic tumours. The initial experience with 14 patients operated for hepatic tumours (5 primary and 9 metastatic) is presented. The paper also presents the technique concerning the intensity and duration of the power applied, the association with the surgical resection, the immediate postoperative evolution and the dynamics of the hepatic enzymes as well as the postoperative results of ultrasound and CT examinations performed within the first 6 weeks. The indications of RF during laparotomy and the place of RF ablation in the treatment of liver tumours in comparison with other ablation techniques are discussed

Total Intravenous Anesthesia-Target Controlled Infusion for colorectal surgery. Remifentanil TCI vs sufentanil TCI.

The aim of the study was to compare the effect of remifentanil and sufentanil administered for total intravenous anaesthesia (TIVA) using target-controlled infusion (TCI) on intraoperative hemodynamic response, tracheal intubation and extubation times in patients undergoing colorectal surgery. METHODS: Sixty patients undergoing open colorectal surgery for colorectal tumors or inflammatory diseases were randomized prospectively into one of two groups: remifentanil group R (n = 30) received TIVA-TCI with propofol and remifentanil and sufentanil group S (n = 30) received TIVA-TCI with propofol and sufentanil. Changes of mean arterial pressure (MAP) and heart rate (HR) were compared during induction and maintenance of anaesthesia. Response to tracheal intubation was assessed as episodes of hypertension, increased HR and bispectral index values, sweating, lacrimation, and coughing. The numbers of target plasma concentration (Cp) adjustments of opioids and propofol due to painful stimulation were recorded during surgery. Recovery time expressed as extubation time was also evaluated. RESULTS: MAP and HR, expressed as area under the curve (AUC), were not significantly different between groups during anesthesia and surgery. During induction of anesthesia, MAP values decrease from baseline, in both groups (p < 0.001). Intergroup comparison revealed that MAP decreased more in the remifentanil than sufentanil group (p = 0.027). HR decreased from baseline values only in the remifentanil group (p = 0.05). The number of target concentration adjustments for propofol and opioid was higher in the remifentanil group as compared with sufentanil group (p = 0.02 and p = 0.04). Hemodynamic responses to tracheal intubation and extubation times were not significantly different between the groups. CONCLUSION: Both remifentanil and sufentanil TCI produced stable hemodynamic conditions during open colorectal surgery but sufentanil TCI was associated with less decrease in blood pressure and heart rate, and required fewer dose adjustments during anesthesia induction.

Biliary plastic stent as a matrix core for lithogenesis in the common bile duct: a rare cause of jaundice.

BACKGROUND: The obstruction of the main bile duct by a foreign body, followed by lithogenesis at that level, is rarely encountered in the literature especially when the foreign body is a plastic biliary stent. We have not found referrals concerning the stone formation as a complication at the level of a biliary stent. CASE REPORT: A 59-year-old female patient was referred with abdominal pain and jaundice. The patient had had a biliary prosthesis inserted 42 months earlier for treatment of biliary stenosis and fistula, complications that occurred after a laparoscopic cholecystectomy. Imaging investigations evidenced the presence of obstructive jaundice and the biliary stent with gall stones adherent on its surface. After the failure of an endoscopic extraction attempt, surgical intervention ensured the removal of the stent and the gallstones formed on its surface. CONCLUSION: The particularity of the case consists of the rarity of such a complication after biliary stenting. At the same time, it emphasizes the need for postoperative follow-up, in order to avoid this kind of complication, potentially fatal.

Bouveret syndrome associated with acute gangrenous cholecystitis.

An 89-year-old patient was hospitalized with signs of acute lithiasic cholecystitis and gastric emptying failure. The decision for surgery was taken and a subhepatic block was evidenced, caused by a perforated gangrenous cholecystitis with pericholecystic abscess, a cholecysto-antroduodenal fistula with two gallstones, 9/5 and 4/3 cm in size, impacted in the duodenum. It was necessary to perform an Y-en-Roux antroduodenojejunal anastomosis because an antroduodenal parietal defect resulted after the removal of the gangrenous gallbladder. The immediate and long term postoperative evolution in terms of anastomosis functionality was good.

Host-related predictive factors for anastomotic leakage following large bowel resections for colorectal cancer.

AIM: To identify the risk, the host-related prognostic factors and their predictive value for anastomotic leakage after colorectal resections following cancer. METHOD: 993 patients who underwent large bowel resection and primary anastomosis above 12 centimeters from the anal verge, without a temporary or permanent stoma at the Surgical Hospital No.3 (Cluj-Napoca, Romania) were retrospectively reviewed. RESULTS: 32 (3.22 percent) anastomotic leaks were confirmed. Univariate analysis showed that the preoperative variables significantly associated with anastomotic leakage included: weight loss, smoking, cardiovascular disease, lung disease, hypoproteinemia, diabetes, anemia, leukocytosis, presence of two or more underlying diseases. Alcohol use, cerebrovascular disease, bowel preparation, type of anastomosis, tumor location, stage and histology were not significant variables. Hypoproteinemia (total serum protein level < or = 6 g/dl) and anemia (serum hemoglobin level < or = 11 g/dl) remained significant in the logistic regression model. The prognostic role of serum hemoglobin and proteins for the anastomotic leak was assessed using ROC curve analysis. For the cut-off value of serum protein level = 5.5 g/dl, a sensitivity of 61.6 percent and a specificity of 84.2 percent were calculated. The area under the curve was 0.703 (p= 0.0024). The area under the curve for serum hemoglobin was 0.616 (p=0.028). A sensitivity of 64.0 percent and a specificity of 64.7 per cent were obtained for a cut-off value of 9.4 g/dl. CONCLUSION. A serum protein level lower than 5.5 g/dl and serum hemoglobin lower than 9.4 g/dl could be considered as host-related predictive markers for anastomotic leak in large bowel resections for cancer.