Effect of empiric intravenous intralipid therapy on pregnancy outcome in women with unexplained recurrent implantation failure undergoing intracytoplasmic sperm injection-embryo transfer cycle: a randomized controlled trial.

To evaluate the effect of empiric intralipid infusion therapy on pregnancy outcomes for patients with unexplained recurrent implantation failure (RIF) undergoing intracytoplasmic sperm injection (ICSI). A total of 142 patients with a history of unexplained RIF (3 or more cycles) were included in this randomized controlled trial. Patients were randomized into two groups, study group (n = 71) and control group (n = 71). The study group received intralipid 20% infusion on the day of embryo transfer (ET) and a second dose on the day of pregnancy test. The clinical pregnancy rate in the study group was 36.6% (n = 26) compared to 28.2% (n = 20) in the control group (OR 1.47, CI 0.72-2.98, p = .282). The live birth rate in the study group was 18.3% (n = 13) and 14.1% (n = 10) in the control group (OR 1.37, CI 0.55-3.36, p=.49). No side effects of intralipid therapy were reported in the study period. There was improvement in the pregnancy rate among women with unexplained RIF who received empiric intralipid infusion therapy; however, this improvement did not reach statistical significance.

Pregnancy with cervical dysgenesis.

OBJECTIVE: To report a case of cervical dysgenesis in a patient who became pregnant through IVF and transmyometrial ET. DESIGN: Case report. SETTING: King Fahad Medical City. PATIENT(S): A 28-year-old nulligravida with cervical dysgenesis who underwent IVF and transmyometrial ET. INTERVENTION(S): Controlled ovarian hyperstimulation, IVF, and transmyometrial ET. MAIN OUTCOME MEASURE(S): Successful intrauterine pregnancy. RESULT(S): Single intrauterine pregnancy was achieved 30 days after transmyometrial ET. CONCLUSION(S): Successful pregnancy is possible in similar patients, eliminating the need for reconstructive surgery.