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BACKGROUND: A clinical practice guideline (CPG) reporting checklist is used to assist CPG developers in recording what content should be provided in a CPG report. Recently, two checklists have become available on the Enhancing the QUAlity and Transparency Of health Research Network website: AGREE (Appraisal of Guidelines, Research and Evaluation) published in 2016 and RIGHT (Reporting Items for practice Guidelines in HealThcare) published in 2017. The objective of this study was to describe the advantages and disadvantages of these two CPG reporting checklists. METHODS: Two epidemiologists who lacked experience using both AGREE and RIGHT but were familiar with evidence-based medicine methodology independently compared AGREE with RIGHT on an item-by-item basis. Their assessments were compiled on a pre-designed data form and any disagreements were resolved through discussion. Three other co-authors independently compared AGREE with RIGHT and decided if they agreed with the results of comparison of the two CPG reporting checklists from the first two co-authors. Finally, another co-author reviewed the comparison results to ensure that the description was clear and understandable. RESULTS: The following six relationships between the two checklists were observed: (1) 11 items from AGREE completely matched with 12 items from RIGHT; (2) four items were listed in AGREE only; (3) 12 items were listed in RIGHT only; (4) three items in AGREE were partially covered by three items in RIGHT; (5) six items in RIGHT were partially covered by three items in AGREE; and (6) two items intersected across AGREE and RIGHT. Based on the comparison results, the potential impact analysis of selecting either checklist is described. DISCUSSION: We recommend that CPG developers use either AGREE plus items unique to RIGHT or RIGHT plus items unique to AGREE.
Assuntos
Lista de Checagem , Relatório de Pesquisa , Atenção à Saúde , Medicina Baseada em Evidências , HumanosRESUMO
BACKGROUND: Total hip and knee replacement decrease the disability caused by osteoarthritis of the lower extremities. Although it has been established that racial and ethnic minorities underutilize these procedures, little data on postoperative outcomes exists. The impact of race on postoperative Oxford scores and complications following total joint arthroplasty (TJA) will be investigated in this retrospective review. METHODS: A retrospective review of 120 elective primary TJA procedures was undertaken between January 2016 and December 2019 in a single institution. To measure variations between the various groups, t-tests were used on their Oxford scores, and chi-squared bivariate regression was used to classify all categorical variables and the association of ethnicity and surgery type with gender. RESULTS: There were 62 (51.6%) White patients and 59 (49.1.0%) Black, Asian, Minority Ethnic (BAME) patients in total. The majority of the patients were females (60.9% vs 39.2%, p = 0.032). Low vitamin D levels were seen in a small percentage of patients in the sample (15.8% vs 84.2%, p = 0.460). There is a statistically important connection (p = 0.001) between the surgery type (total knee replacement [TKR]/total hip replacement [THR]) and gender; 41 females had TKR surgery, and 32 had THR surgery. CONCLUSION: The study found that the relationships between ethnicity (White/BAME) and gender as well as surgery type (TKR/THR) and gender are statistically important. In all cases with low vitamin D and normal vitamin D levels, White patients had higher overall Oxford hip scores than the BAME patients. To comprehend the differences discovered, further research is needed. To try to eliminate the difference, targeted approaches should be created.
RESUMO
Malaria is a life-threatening infectious disease that, in severe cases, is associated with calamitous complications and far-reaching consequences within a community. It is usually manifested by abnormalities in various hematological indices with anemia and thrombocytopenia being the most frequent ones. The present study sheds light on the laboratory profile of patients suffering from malaria and provides a comprehensive analysis and correlation with the available literature worldwide. The study was carried out as a cross-sectional study at OK Diagnostic Lab and Research Center in Peshawar from October 2010 to October 2013. All malaria parasite (MP)-positive cases reported at OK Lab during the study period were employed in the study, making a total of 136 MP positive cases. Complete blood pictures with platelet counts were obtained in all patients and various hematological indices were analyzed according to the World Health Organization (WHO) criteria. Thrombocytopenia was defined as a platelet count of < 150 × 103/cmm and anemia as an hemoglobin (Hb) < 13 g/dL in males and < 12 g/dL in females. Among the 136 MP positive patients, 74 (55.4%) had associated thrombocytopenia while 105 (77.2%) patients showed anemia on a peripheral blood smear. This was followed by leukopenia in 8.8% of cases. Among patients with Plasmodium falciparum (P. falciparum) infection, anemia was present in 80% of cases as compared to 74% cases with P. vivax infection (p = 0.5). Thrombocytopenia was associated with P. vivax infection in 71.4% of cases in contrast to P. falciparum infection, where 26% of cases had associated thrombocytopenia (p = 0.01). On the contrary, leukopenia was more prevalent in P. falciparum patients (18%), followed by P. vivax (2.6%), and mixed parasitemia (11.1%) (p < 0.001). In addition, the study showed statistically significant variations in hematocrit (Hct), mean corpuscular volume (MCV), mean corpuscular hemoglobin concentration (MCHC), and platelet counts across different malarial species (p < 0.05). Likewise, variations within mean Hct levels among males and females were statistically significant, with females showing lower mean Hct levels than males (p < 0.05).