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1.
BMC Neurol ; 22(1): 78, 2022 Mar 07.
Artigo em Inglês | MEDLINE | ID: mdl-35255837

RESUMO

BACKGROUND: After a stroke, several aspects of health and function may influence how individuals perceive their own health. However, self-rated health (SRH), as well as its relationship with functioning, has been little explored in individuals with stroke. The aims of this study were to determine how individuals with chronic post-stroke disabilities evaluate their health, considering general, time- and age-comparative SRH questions and to investigate whether SRH measures would be influenced by the following health and functioning domains: mental/physical functions and personal factors. METHODS: Sixty-nine individuals with chronic post-stroke disabilities answered the three types of SRH questions and were assessed regarding depressive symptoms (emotional function domain), physical activity levels (physical function domain), and engagement in physical activity practice (personal factor domain). Subjects were divided into the following groups: good/poor for the general SRH question; better, similar, and "worse" for both time- and age-comparative questions. Between-group differences in the three domains for each SRH question were investigated (α = 5%). RESULTS: General SRH was rated as good by 73% of the participants. Time- and age-comparative SRH was rated as better by 36% and 47% and as similar by 31% and 28% of the subjects, respectively. Significant between-group differences in emotional function were found for both the general and age-comparative questions. For the time-comparative question, significant differences were only observed for physical function. CONCLUSION: SRH evaluation differed in individuals with chronic post-stroke disabilities according to the types of questions and health/functioning domains.


Assuntos
Acidente Vascular Cerebral , Dano Encefálico Crônico , Pessoal de Saúde , Humanos , Avaliação de Resultados em Cuidados de Saúde , Acidente Vascular Cerebral/epidemiologia
2.
Lasers Med Sci ; 36(2): 311-315, 2021 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-32372235

RESUMO

Biosafety materials used in the correct handling of low power laser equipment may interfere on the power delivered at the target tissue and, possibly, on the effects on biological tissues. The aim of this study was to evaluate the interference of the use of polyvinyl chloride (PVC) and polyethylene (PEAD) protection materials on the output power of low power lasers. Two low power diode laser devices with different wavelengths (red and infrared) were used. For each wavelength, two protection materials and two evaluation times (before and after protection) were considered. The output power (mW) was measured with the tip positioned in close contact with the power meter receiver. Parametric statistical test, two-way ANOVA for repeated measures (protection material and time), was performed considering the level of significance of 5%. In respect to "time", all groups had the output power reduced after placing the protective material (p < 0.05). Comparing the protection materials, the PEAD showed a greater reduction in output power than the PVC for both red and infrared wavelengths. It was concluded that, among the biosafety materials tested, PVC is the most suitable for the protection of the tip of the low power lasers.


Assuntos
Contenção de Riscos Biológicos , Lasers , Humanos , Raios Infravermelhos , Polietileno/química , Cloreto de Polivinila/química
3.
BMC Neurol ; 19(1): 221, 2019 Sep 07.
Artigo em Inglês | MEDLINE | ID: mdl-31493791

RESUMO

BACKGROUND: Self-rated health (SRH) allows for comparison and identification of the health status of various populations. The aim of this study was to conduct a systematic review of the literature to expand the understanding of SRH after stroke. METHODS: This systematic review was registered with PROSPERO (CRD42017056194) and conducted according to PRISMA guidelines. Studies published until December 2018 that evaluated the SRH of adults with stroke were included. RESULTS: Of the 2132 identified studies, 51 were included. Only four studies had experimental designs (7.8%). In 60.7% of the studies, SRH was assessed by variations on direct questions (i.e., general and comparative SRH). Analog visual scales and quality of life instruments were also used to evaluate SRH, but there is no consensus regarding whether they are appropriate for this purpose. The results of cross-sectional and longitudinal studies revealed significant associations between poor SRH and stroke as well as between SRH, function, and disability. The power of SRH to predict stroke mortality is still uncertain. Two interventions (a home-based psychoeducational program concerning stroke health care and family involvement in functional rehabilitation) effectively improved SRH. CONCLUSIONS: Direct questions are the most common method of evaluating SRH after stroke. Studies reported significant associations between the SRH of individuals with stroke and several relevant health outcomes. However, few experimental studies have evaluated SRH after stroke. Interventions involving health education and family involvement had a significant impact on SRH.


Assuntos
Nível de Saúde , Qualidade de Vida , Acidente Vascular Cerebral/fisiopatologia , Adulto , Humanos
4.
Am J Dent ; 32(4): 159-164, 2019 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-31436934

RESUMO

PURPOSE: To compare the effect of thermal cycling and erosive challenge on color change, surface roughness, surface loss and biofilm deposition of three resin-based composites. METHODS: Three resin-based composites that reproduce the color of gingival tissues [two nanohybrid composites (A and B) and a giomer (C) ] were tested before and after distinct challenges [ thermal cycling (TC) and erosive challenge (EC) ] in regard to its color stability, surface roughness, surface loss and biofilm deposition. Surface roughness and surface loss specimens (n=10) were measured with an optical profilometer and, color stability (n=10) was measured with a spectrophotometer. Biofilm deposition (n=5) was measured after 3 and 24 hours by safranin staining. RESULTS: Two-way ANOVA test was performed to analyze color change, roughness and surface loss. A significant color change was detected for resin-based composites (P< 0.05) and its interaction with tested challenges (P< 0.05). The highest color variation was observed on the giomer after erosive challenge. Surface loss was not different between tested groups (P= 0.708). The roughness was significantly higher in specimens submitted to thermal cycling (P> 0.05). For biofilm quantification, after 3 and 24 hours, ANOVA (3-way) detected significance for the interaction of challenges and resin-based composites (P< 0.05 and P< 0.05, respectively). All resin-based composites presented color changes after challenges; higher roughness was observed after thermal cycling for all resin-based composites tested, without significant surface loss; and higher biofilm deposition was observed on the giomer samples when submitted to erosive challenge after 3 and 24 hours. CLINICAL SIGNIFICANCE: Pink esthetic is as important as dental esthetics and some restorative materials can mimic gingival tissue. However, the tested giomer must be indicated with caution, since it presented significant changes after thermal and acid challenges.


Assuntos
Resinas Compostas , Materiais Dentários , Cor , Estética Dentária , Teste de Materiais , Propriedades de Superfície
5.
J Appl Oral Sci ; 32: e20230458, 2024.
Artigo em Inglês | MEDLINE | ID: mdl-38922241

RESUMO

OBJECTIVE: This study compared three protocols for developing artificial white spot lesions (WSL) using biofilm models. METHODOLOGY: In total, 45 human enamel specimens were sterilized and allocated into three groups based on the biofilm model: Streptococcus sobrinus and Lactobacillus casei (Ss+Lc), Streptococcus sobrinus (Ss), or Streptococcus mutans (Sm). Specimens were incubated in filter-sterilized human saliva to form the acquired pellicle and then subjected to the biofilm challenge consisting of three days of incubation with bacteria (for demineralization) and one day of remineralization, which was performed once for Ss+Lc (four days total), four times for Ss (16 days total), and three times for Sm (12 days total). After WSL creation, the lesion fluorescence, depth, and chemical composition were assessed using Quantitative Light-induced Fluorescence (QLF), Polarized Light Microscopy (PLM), and Raman Spectroscopy, respectively. Statistical analysis consisted of two-way ANOVA followed by Tukey's post hoc test (α=0.05). WSL created using the Ss+Lc protocol presented statistically significant higher fluorescence loss (ΔF) and integrated fluorescence (ΔQ) in comparison to the other two protocols (p<0.001). RESULTS: In addition, Ss+Lc resulted in significantly deeper WSL (137.5 µm), followed by Ss (84.1 µm) and Sm (54.9 µm) (p<0.001). While high mineral content was observed in sound enamel surrounding the WSL, lesions created with the Ss+Lc protocol showed the highest demineralization level and changes in the mineral content among the three protocols. CONCLUSION: The biofilm model using S. sobrinus and L. casei for four days was the most appropriate and simplified protocol for developing artificial active WSL with lower fluorescence, higher demineralization, and greater depth.


Assuntos
Biofilmes , Cárie Dentária , Esmalte Dentário , Lacticaseibacillus casei , Streptococcus mutans , Humanos , Streptococcus mutans/fisiologia , Cárie Dentária/microbiologia , Cárie Dentária/terapia , Esmalte Dentário/microbiologia , Esmalte Dentário/química , Lacticaseibacillus casei/fisiologia , Fatores de Tempo , Reprodutibilidade dos Testes , Streptococcus sobrinus/fisiologia , Análise Espectral Raman , Análise de Variância , Microscopia de Polarização , Estatísticas não Paramétricas , Remineralização Dentária/métodos , Valores de Referência , Saliva/microbiologia , Saliva/química , Desmineralização do Dente/microbiologia , Fluorescência
6.
Int Immunopharmacol ; 134: 112215, 2024 Jun 15.
Artigo em Inglês | MEDLINE | ID: mdl-38744173

RESUMO

Camelid single-domain antibodies (VHH) represent a promising class of immunobiologicals for therapeutic applications due to their remarkable stability, specificity, and therapeutic potential. To enhance the effectiveness of antivenoms for snakebites, various methods have been explored to address limitations associated with serum therapy, particularly focusing on mitigating local damage and ensuring sustainable production. Our study aimed to characterize the pharmacological profile and neutralization capacity of anti-Phospholipase A2 (PLA2) monomeric VHH (Genbank accessions: KC329718). Using a post-envenoming mouse model, we used intravital microscopy to assess leukocyte influx, measured CK and LDH levels, and conducted a histopathology analysis to evaluate VHH KC329718's ability to neutralize myotoxic activity. Our findings demonstrated that VHH KC329718 exhibited heterogeneous distribution in muscle tissue. Treatment with VHH KC329718 reduced leukocyte influx caused by BthTX-I (a Lys-49 PLA2) by 28 %, as observed through intravital microscopy. When administered at a 1:10 ratio [venom or toxin:VHH (w/w)], VHH KC329718 significantly decreased myotoxicity, resulting in a 35-40 % reduction in CK levels from BthTX-I and BthTX-II (an Asp-49 PLA2) and a 60 % decrease in CK levels from B. jararacussu venom. LDH levels also showed reductions of 60%, 80%, and 60% induced by BthTX-I, BthTX-II, and B. jararacussu venom, respectively. Histological analysis confirmed the neutralization potential, displaying a significant reduction in tissue damage and inflammatory cell count in mice treated with VHH KC329718 post B. jararacussu venom inoculation. This study underscores the potential of monomeric anti-PLA2 VHH in mitigating myotoxic effects, suggesting a promising avenue for the development of new generation antivenoms to address current therapeutic limitations.


Assuntos
Antivenenos , Bothrops , Fosfolipases A2 , Anticorpos de Domínio Único , Mordeduras de Serpentes , Animais , Anticorpos de Domínio Único/imunologia , Mordeduras de Serpentes/tratamento farmacológico , Mordeduras de Serpentes/imunologia , Antivenenos/farmacologia , Antivenenos/uso terapêutico , Camundongos , Fosfolipases A2/metabolismo , Venenos de Crotalídeos/imunologia , Venenos de Crotalídeos/toxicidade , Masculino , Modelos Animais de Doenças , Músculo Esquelético/patologia , Músculo Esquelético/efeitos dos fármacos , Leucócitos/efeitos dos fármacos , Leucócitos/imunologia , Humanos , Creatina Quinase/sangue
7.
J Med Chem ; 66(12): 8281-8287, 2023 06 22.
Artigo em Inglês | MEDLINE | ID: mdl-37279490

RESUMO

Heterobifunctional PROTAC degraders are gaining attention as a differentiated therapeutic modality with the potential for oral dosing in the clinic. Belonging to the beyond Rule of Five domain of physicochemical property space, we have sought to understand the determinants of oral absorption for this class of molecules for the rapid development of novel oral agents. We have collected a large data set from PROTAC molecules that have been dosed orally and intravenously in rats to estimate the fraction absorbed from oral dosing. Through this estimation, effects from differential hepatic clearance are normalized, allowing for a better assessment of the absorption. We demonstrate that rats are less permissive to PROTAC absorption than mice. The physicochemical properties of the molecules are then evaluated once compounds are rank-ordered by the fraction absorbed. We derive suggested design constraints on physicochemical properties for PROTAC molecules that are associated with higher probability of being orally absorbed.


Assuntos
Fígado , Ratos , Camundongos , Animais , Proteólise
8.
ACS Med Chem Lett ; 14(4): 345-349, 2023 Apr 13.
Artigo em Inglês | MEDLINE | ID: mdl-37077389

RESUMO

On the occasion of the 2023 International Women's Day on March 8, 2023, we want to celebrate and highlight the contributions of many women volunteers in the American Chemical Society Division of Medicinal Chemistry (ACS MEDI).

9.
J Med Chem ; 66(6): 3651-3655, 2023 03 23.
Artigo em Inglês | MEDLINE | ID: mdl-36884261

RESUMO

On the occasion of the 2023 International Women's Day on March 8, 2023, we want to celebrate and highlight the contributions of many women volunteers in the American Chemical Society Division of Medicinal Chemistry (ACS MEDI).


Assuntos
Química Farmacêutica , Humanos , Feminino , Estados Unidos
10.
PLoS One ; 18(7): e0287814, 2023.
Artigo em Inglês | MEDLINE | ID: mdl-37467188

RESUMO

The relationship between N-antigen concentration and viral load within and across different specimens guides the clinical performance of rapid diagnostic tests (RDT) in different uses. A prospective study was conducted in Porto Velho, Brazil, to investigate RDT performance in different specimen types as a function of the correlation between antigen concentration and viral load. The study included 214 close contacts with recent exposures to confirmed cases, aged 12 years and older and with various levels of vaccination. Antigen concentration was measured in nasopharyngeal swab (NPS), anterior nares swab (ANS), and saliva specimens. Reverse transcriptase (RT)-PCR was conducted on the NPS and saliva specimens, and two RDTs were conducted on ANS and one RDT on saliva. Antigen concentration correlated well with viral load when measured in the same specimen type but not across specimen types. Antigen levels were higher in symptomatic cases compared to asymptomatic/oligosymptomatic cases and lower in saliva compared to NPS and ANS samples. Discordant results between the RDTs conducted on ANS and the RT-PCR on NPS were resolved by antigen concentration values. The analytical limit-of-detection of RDTs can be used to predict the performance of the tests in populations for which the antigen concentration is known. The antigen dynamics across different sample types observed in SARS-CoV-2 disease progression support use of RDTs with nasal samples. Given lower antigen concentrations in saliva, rapid testing using saliva is expected to require improved RDT analytical sensitivity to achieve clinical sensitivity similar to rapid testing of nasal samples.


Assuntos
COVID-19 , SARS-CoV-2 , Humanos , SARS-CoV-2/genética , Carga Viral , Estudos Prospectivos , COVID-19/diagnóstico , Testes Sorológicos , Saliva , Manejo de Espécimes , Sensibilidade e Especificidade , Nasofaringe
11.
J Med Chem ; 65(9): 6353-6355, 2022 05 12.
Artigo em Inglês | MEDLINE | ID: mdl-35467872

RESUMO

The Young Medicinal Chemists Committee (YMCC) is a part of the larger ACS Division of Medicinal Chemistry (MEDI) and was formed to ensure that MEDI meets the needs of all medicinal chemists, including students and early career scientists. There is a clear need to offer additional, specific opportunities to this group of medicinal chemists within the MEDI division. Primary functions of YMCC include facilitating networking and mentorship opportunities, collaborating with international medicinal chemistry societies, and offering social programming for all MEDI members at ACS National Meetings. We are excited to continue to engage students and early career chemists through new initiatives and programming in the future. In this Editorial we highlight current initiatives relevant to early career medicinal chemists and solicit input from the larger medicinal chemistry community.


Assuntos
Química Farmacêutica , Humanos
12.
Int J Exerc Sci ; 14(3): 177-186, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-34055158

RESUMO

The purpose of the study was to assess whether there are differences in cardiorespiratory fitness between children with and without cystic fibrosis (CF). Ten children with CF attended at a referral center for the treatment of CF and 13 children without CF were evaluated. The average age of the children with CF was 10.40 (3.13) years and those without CF was 9.39 (3.25) years. The children performed the three-minute step test with monitoring of hemodynamic parameters and the rating of perceived exertion (RPE) every minute. Oxygen desaturation of 4% during the test occurred in three children with CF and none of the children reached a SatO2 percentage < 75%. After the step test, the findings showed that children with CF presented higher RPE scores during the test (p = 0.002) when compared to children without CF (p < 0.001). The RPE was the only parameter that changed during the test and demonstrated that children with cystic fibrosis tired more during the test when compared to children without CF despite the lack of changes in hemodynamic variables.

13.
ACS Med Chem Lett ; 12(3): 443-450, 2021 Mar 11.
Artigo em Inglês | MEDLINE | ID: mdl-33732413

RESUMO

While the discovery of immune checkpoint inhibitors has led to robust, durable responses in a range of cancers, many patients do not respond to currently available therapeutics. Therefore, an urgent need exists to identify alternative mechanisms to augment the immune-mediated clearance of tumors. Hematopoetic progenitor kinase 1 (HPK1) is a serine-threonine kinase that acts as a negative regulator of T-cell receptor (TCR) signaling, to dampen the immune response. Herein we describe the structure-based discovery of isofuranones as inhibitors of HPK1. Optimization of the chemotype led to improvements in potency, selectivity, plasma protein binding, and metabolic stability, culminating in the identification of compound 24. Oral administration of 24, in combination with an anti-PD1 antibody, demonstrated robust enhancement of anti-PD1 efficacy in a syngeneic tumor model of colorectal cancer.

14.
J Rehabil Med ; 52(7): jrm00080, 2020 Jul 30.
Artigo em Inglês | MEDLINE | ID: mdl-32719885

RESUMO

OBJECTIVE: To investigate whether variables of function and disability, which have potential to be modified by rehabilitation, are determinants of self-rated health in post-stroke individuals in the chronic phase. DESIGN: Cross-sectional exploratory study. METHODS: The dependent variable was self-rated health. The independent variables were organized according to the International Classification of Functioning, Disability and Health components: body structure and function (emotional function and motor recovery level), activity (manual and locomotion skill), and participation (participation). Logistic regression analysis was performed to identify significant associations between the independent variables and self-rated health (?=5%). RESULTS: Sixty-three individuals were included in the study: 44 (70%) rated their own health as good (excellent/very good/good) and 19 (30%) as poor (fair/poor). Significant association with self-rated health was identified only for emotional function. Individuals with impaired emotional function were 6.6 times more likely to assess their own health as poor (odds ratio (OR) 6.56; 95% confidence interval (95% CI) 1.5328.21). CONCLUSION: Emotional function was found to be a determinant of self-rated health in post-stroke individuals in the chronic phase and, therefore, must be assessed carefully in order to help provide integral healthcare and improve clinical decision-making. Future studies should investigate whether enhancing emotional function is associated with improvements in self-rated health in post-stroke individuals.


Assuntos
Acidente Vascular Cerebral/psicologia , Idoso , Estudos Transversais , Feminino , Humanos , Masculino
15.
Prog Biomater ; 8(1): 23-29, 2019 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-30725401

RESUMO

In vitro effect of 1% theobromine addition on the physical and chemical properties of conventional glass ionomer (GIC) cement was investigated. Conventional GIC (GIC-C) and 1% theobromine added to GIC (GIC-THEO) specimens were compared regarding the microhardness (n = 10), sorption (n = 5), solubility (n = 5), color change (n = 10), fluoride release in saliva (n = 10) and the amount of biofilm deposition (n = 20). Compared against conventional GIC, adding 1% theobromine increased microhardness (p < 0.05), while its sorption, solubility, color and fluoride release to saliva (p > 0.05) remained unchanged. On the other hand, Streptococcus mutans biofilm amount deposited on its surface decreased statistically when theobromine was added to GIC (p < 0.05). Based on the results, it could be concluded that 1% theobromine addition to GIC can be a good strategy as it keeps some of its properties and improves microhardness and biofilm deposits strengthening its role in the preventive approach of dentistry.

16.
J Lasers Med Sci ; 10(1): 75-78, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31360373

RESUMO

Introduction: The labial frenum is a fold of mucous membrane that attaches the lip and the cheek to the alveolar mucosa, the gingiva, and the underlying periosteum. In some cases, its presence can cause a midline diastema, periodontal diseases related to food impaction, or retention of biofilm, among others. In such cases, lip frenectomy is indicated as treatment, which can be performed with a scalpel (conventional method), an electric scalpel, or a surgical laser. Objective: To show a clinical case performed at Laser Extension Project in Dentistry, Federal University of Maranhão grounded in a literature review. Case Presentation: A laser frenectomy was performed on a female patient, aged 20, who had a diastema between the upper central incisors and an indication for frenum removal. The high-power diode laser is excellent for procedures in soft tissue because its wavelength is well absorbed by hemoglobin and other pigments; its use also allows a reduction in the amount of anesthetic and medicines used. The parameters used were 2 W, in a continuous mode, 808 nm infrared emission; with delivery of the beam through optical fiber 300 µM; energy of 120 J; 20 pps. Conclusion: the high power diode laser allowed a satisfactory result, the procedure was safe, the technique was a simple one and of reduced clinical time, as mentioned in the literature. It is worth noting that the technique is dependent on the skill of the professional performing it.

17.
Fisioter. Pesqui. (Online) ; 31: e23014824en, 2024. tab, graf
Artigo em Inglês | LILACS-Express | LILACS | ID: biblio-1557770

RESUMO

ABSTRACT After hospital discharge, it is recommended that post-stroke individuals receive follow-up by a physical therapist throughout all the stages of recovery. Despite clinical recommendations, few studies have investigated physical therapy care to community-dwelling individuals with stroke. This study aimed to describe physical therapy care to community-dwelling individuals with stroke in primary care setting and identify clinical-functional and sociodemographic characteristics that determined physical therapy assistance. This is an exploratory cross-sectional study. Community-dwelling individuals with stroke who were assisted by the primary healthcare team from an important Brazilian metropolis were included. Their medical records were analyzed to identify the care provided by physical therapists. Individuals who received and did not receive physical therapy care were compared (α=0.05). Out of the 100 included individuals, 55% received assistance from the multidisciplinary primary healthcare team and 44% from physical therapists. Physical therapy approaches consisted mainly of general orientations (89%) and assessments (75%). Only 45% of the individuals who received physical therapy care were followed-up, and those who received this type of care had significantly more stroke events and higher levels of disability (p<0.001). It was observed that many individuals with various levels of disabilities have not received physical therapist assistance. Moreover, follow-up care and referrals were not frequent physical therapy approaches. Therefore, physical therapy care in primary care needs to be expanded to ensure that all individuals with some level of disability receive treatment. Moreover, it is necessary to increase the number of individuals receiving follow-up and encourage multidisciplinary work between physical therapists and other primary healthcare professionals.


resumen está disponible en el texto completo


RESUMO Após a alta hospitalar, recomenda-se que pacientes pós-AVC sejam acompanhados por um fisioterapeuta durante toda a recuperação. Apesar das recomendações clínicas, poucos estudos investigaram os cuidados fisioterapêuticos a indivíduos pós-AVC residindo na comunidade. O estudo objetivou descrever os cuidados fisioterapêuticos prestados a indivíduos que sofreram AVC residentes na comunidade em contexto de atenção primária e identificar as características clínico-funcionais e sociodemográficas que determinam a assistência de fisioterapia. Este é um estudo transversal exploratório. Foram incluídos pacientes pós-AVC, residentes na comunidade e que foram atendidos pela equipe multidisciplinar de quatro unidades de atenção primária à saúde de uma importante metrópole brasileira. Os prontuários foram analisados para identificar os cuidados prestados pelos fisioterapeutas. Os indivíduos que receberam e não receberam cuidados fisioterapêuticos foram comparados (α=0,05). Dos 100 indivíduos incluídos, 55% receberam assistência de profissionais da equipe multidisciplinar e 44% foram atendidos por fisioterapeutas. As abordagens de fisioterapia consistiram principalmente em instruções (89%) e avaliações (75%). Apenas 45% dos indivíduos que receberam cuidados fisioterapêuticos foram acompanhados, e aqueles que receberam esses cuidados apresentaram um número significativamente maior de eventos de AVC e níveis mais altos de incapacidade (p<0,001). Observou-se que muitas pessoas com diferentes níveis de incapacidade não receberam assistência fisioterapêutica. Além disso, o acompanhamento e os encaminhamentos não foram frequentes nas práticas fisioterapêuticas. Portanto, os cuidados fisioterapêuticos na atenção primária precisam ser ampliados para garantir que todos os indivíduos com algum nível de incapacidade recebam tratamento. Ademais, é preciso aumentar o número de indivíduos que recebem acompanhamento e incentivar o trabalho multidisciplinar entre fisioterapeutas e outros profissionais da área de saúde.

18.
J. appl. oral sci ; 32: e20230458, 2024. tab, graf
Artigo em Inglês | LILACS-Express | LILACS | ID: biblio-1564708

RESUMO

Abstract Creating artificial caries-like lesions that mimic the complex changes observed in natural caries is essential for properly evaluating new strategies, dental materials, and devices designed to arrest their progression and avoid more costly and invasive treatments. Objective This study compared three protocols for developing artificial white spot lesions (WSL) using biofilm models. Methodology In total, 45 human enamel specimens were sterilized and allocated into three groups based on the biofilm model: Streptococcus sobrinus and Lactobacillus casei (Ss+Lc), Streptococcus sobrinus (Ss), or Streptococcus mutans (Sm). Specimens were incubated in filter-sterilized human saliva to form the acquired pellicle and then subjected to the biofilm challenge consisting of three days of incubation with bacteria (for demineralization) and one day of remineralization, which was performed once for Ss+Lc (four days total), four times for Ss (16 days total), and three times for Sm (12 days total). After WSL creation, the lesion fluorescence, depth, and chemical composition were assessed using Quantitative Light-induced Fluorescence (QLF), Polarized Light Microscopy (PLM), and Raman Spectroscopy, respectively. Statistical analysis consisted of two-way ANOVA followed by Tukey's post hoc test (α=0.05). WSL created using the Ss+Lc protocol presented statistically significant higher fluorescence loss (ΔF) and integrated fluorescence (ΔQ) in comparison to the other two protocols (p<0.001). Results In addition, Ss+Lc resulted in significantly deeper WSL (137.5 µm), followed by Ss (84.1 µm) and Sm (54.9 µm) (p<0.001). While high mineral content was observed in sound enamel surrounding the WSL, lesions created with the Ss+Lc protocol showed the highest demineralization level and changes in the mineral content among the three protocols. Conclusion The biofilm model using S. sobrinus and L. casei for four days was the most appropriate and simplified protocol for developing artificial active WSL with lower fluorescence, higher demineralization, and greater depth.

19.
Cien Saude Colet ; 23(5): 1551-1560, 2018 May.
Artigo em Português | MEDLINE | ID: mdl-29768609

RESUMO

The National School Food Program (PNAE) constitutes an important strategy for the promotion of healthy eating. The objective was to perform a brief analysis of evaluative research on the PNAE. It involved a search of the literature from 2010 to 2015 in the Bireme and Scielo databases. Twelve articles were selected linked to the area, eight of which analyzed the insertion of the nutritionist in the PNAE; seven, to buy food from family farms; five, the implementation of School Food Councils; five, the compilation of menus; and four, funding destined for the PNAE. Problems in the performance of the nutritionist and the School Food Councils, on buying food from family farms and in the compilation of the menus (low fruit and vegetable content) were detected. The need for greater attention to execution of the PNAE was highlighted in order to ensure school food within guidelines that promote food and nutrition security. Further evaluation studies about the program are fundamental for the provision of subsidies to public managers for purposes of enhancing its implementation.


O Programa Nacional de Alimentação Escolar (PNAE) representa uma estratégia importante de promoção da alimentação saudável. Objetivou-se realizar uma análise sumária das pesquisas avaliativas sobre o PNAE. Pesquisa bibliografica do período de 2010 a 2015 nas bases de dados Bireme e SciELO. Foram selecionados 12 artigos vinculados à área, dos quais oito analisaram a inserção do nutricionista no PNAE; sete, a aquisição de alimentos da agricultura familiar; cinco, a implantação dos Conselhos de Alimentação Escolar; cinco, a execução dos cardápios; e quatro, os recursos financeiros destinados ao PNAE. Apontam-se problemas na atuação do nutricionista e dos Conselhos de Alimentação Escolar, na aquisição de alimentos da agricultura familiar e na composição dos cardápios (baixo conteúdo de frutas e hortaliças). Destaca-se a necessidade de maior atenção relacionada à execução do PNAE, de maneira a garantir uma alimentação escolar dentro de princípios que promovam a segurança alimentar e nutricional. Novos estudos avaliativos sobre o Programa são fundamentais para o fornecimento de subsídios aos gestores públicos com fins de aprimorar a sua execução.


Assuntos
Assistência Alimentar/organização & administração , Serviços de Alimentação/organização & administração , Abastecimento de Alimentos , Dieta Saudável , Humanos , Saúde Pública , Instituições Acadêmicas
20.
Cien Saude Colet ; 23(11): 3637-3647, 2018 Nov.
Artigo em Espanhol | MEDLINE | ID: mdl-30427437

RESUMO

This study sought to identify the association between the concentration of hemoglobin and socio-environmental, maternal, biological-nutritional and health condition characteristics in preschool children; as well as the serum concentrations of zinc and retinol. It involved a cross-sectional study with 335 individuals, a representative sample of children enrolled in child day care centers in the city of Campina Grande, Paraíba. In the 294 children studied, the adjusted model showed lower concentrations of hemoglobin when the house was not made of bricks; there was no sewerage system; no public garbage collection; no treatment of drinking water; maternal difficulties for reading, writing and making calculations; age between 9 - 24 months; weight/age < - 2 score Z and health problems in the last 15 days, as well as in cases of lower serum concentrations of zinc and retinol. The multicausality of lower hemoglobin levels included socio-environmental conditions and child-maternal characteristics that reinforce the importance of measures that prioritize the younger children of mothers with lower education levels and prejudiced in weight, health and nutritional status of other important micronutrients for growth.


El presente estudio buscó identificar en niños preescolares la asociación de las concentraciones de hemoglobina con características socio-ambientales, maternas, biológico-nutricionales y las condiciones de salud; así como con las concentraciones séricas de zinc y retinol. Estudio transversal con muestra de 335 individuos, representativa de los niños de jardines infantiles del municipio de Campina Grande, Paraíba. En los 294 niños estudiados, el modelo ajustado mostró menores concentraciones de hemoglobina en casos de tipo de casa diferente de ladrillo; ausencia de red de escoto; colecta no pública de la basura; no tratamiento del agua para beber; dificultades maternas para leer, escribir o hacer cuentas; edad entre 9-24 meses; peso/edad < - 2 escore Z y problemas de salud en los últimos 15 días, bien como en casos de bajas concentraciones séricas de zinc y retinol. La multicausalidad de concentraciones inferiores de hemoglobina comprendió condiciones socio-ambientales y características materno-infantiles que refuerzan la importancia de medidas que prioricen los niños de menor edad, de madres con menor nivel educacional y con prejuicios en su peso, estado de salud y condición nutricional de otros micronutrientes importantes en el crecimiento.


Assuntos
Hemoglobinas/metabolismo , Estado Nutricional , Vitamina A/sangue , Zinco/sangue , Adulto , Peso Corporal , Brasil , Creches , Pré-Escolar , Estudos Transversais , Escolaridade , Feminino , Nível de Saúde , Humanos , Lactente , Mães/estatística & dados numéricos , Fatores de Risco
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