RESUMO
Evaluation of lymphocyte response has been undertaken in adjuvant-induced arthritis in rats. Lymphocyte reactivity was studied by evaluating lymphocyte transformation in mixed lymphocyte-chondrocyte cultures as well as the response to PHA and M. tuberculosis. It was found that animals immunized with Freund's complete adjuvant showed increased transformation when challenged with M. tuberculosis powder. However, there was a depressed response to PHA and a markedly depressed response in mixed lymphocyte-chondrocyte cultures.
Assuntos
Artrite Experimental/imunologia , Artrite/imunologia , Linfócitos/fisiologia , Animais , Cartilagem Articular/citologia , Células Cultivadas , Epífises , Ativação Linfocitária , Mycobacterium tuberculosis/imunologia , Ratos , Ratos Endogâmicos ACIRESUMO
Stimulation in vitro of allogeneic and syngeneic mixed lymphocyte cultures suggests the presence of differentiation antigens on the surface of the chondrocyte. This may provide part of the answer to the nature of the chronicity of certain arthritic processes.