1.
Bioorg Med Chem Lett
; 9(3): 443-8, 1999 Feb 08.
Artigo
em Inglês
| MEDLINE
| ID: mdl-10091699
RESUMO
Cinnamyl derivatives of thieno[2,3-d]oxazinones are mechanism-based inhibitors of the HSV-2, VZV and CMV herpes proteases which demonstrate nanomolar potency. Compounds 5 and 28 inhibit protease processing in HSV-2 infected cells with a selectivity index of at least 30.