Quantitative measurements in capsule endoscopy.

This review summarizes several approaches for quantitative measurement in capsule endoscopy. Video capsule endoscopy (VCE) typically provides wireless imaging of small bowel. Currently, a variety of quantitative measurements are implemented in commercially available hardware/software. The majority is proprietary and hence undisclosed algorithms. Measurement of amount of luminal contamination allows calculating scores from whole VCE studies. Other scores express the severity of small bowel lesions in Crohn׳s disease or the degree of villous atrophy in celiac disease. Image processing with numerous algorithms of textural and color feature extraction is further in the research focuses for automated image analysis. These tools aim to select single images with relevant lesions as blood, ulcers, polyps and tumors or to omit images showing only luminal contamination. Analysis of motility pattern, size measurement and determination of capsule localization are additional topics. Non-visual wireless capsules transmitting data acquired with specific sensors from the gastrointestinal (GI) tract are available for clinical routine. This includes pH measurement in the esophagus for the diagnosis of acid gastro-esophageal reflux. A wireless motility capsule provides GI motility analysis on the basis of pH, pressure, and temperature measurement. Electromagnetically tracking of another motility capsule allows visualization of motility. However, measurement of substances by GI capsules is of great interest but still at an early stage of development.

Occupational settings facilitating wisdom-related knowledge: the sample case of clinical psychologists.

Wisdom can be defined as expert knowledge in the fundamental pragmatics of life. Examined here is whether clinical practice may facilitate access to and acquisition of such knowledge. Spontaneous think-aloud responses to 2 wisdom-related dilemmas from young (M = 32 years) and older (M = 70 years) clinicians were compared with responses obtained from other professionals. Raters judged clinicians' responses as higher on 5 criteria of wisdom: factual knowledge, procedural knowledge, life-span contextualism, value relativism, and management of uncertainty. Contrary to most studies of cognitive aging, young and older adults did not differ. Rather, each age-cohort group received highest ratings when responding to a life dilemma matched to their own life phase. Discussed is the application of a wisdom framework to assessing therapeutic treatment goals and therapist interventions as well as global changes in client's beliefs during therapy.

Causality, agency, and control beliefs in East versus West Berlin children: a natural experiment on the role of context.

Beliefs about factors that affect school performance (means-ends or causality beliefs) and about self-efficacy and control (agency and control beliefs) were assessed in 313 East Berlin children (grades 2-6) before unification and 516 West Berlin children shortly after unification. Multiple-group analyses of mean and covariance structures yielded 2 major differences: (a) East Berlin children showed lower agency and control beliefs than West Berlin children, and (b) their agency and control beliefs were more highly correlated with school grades than West Berlin children's, with strong correlations already emerging in East Berlin 2nd graders. Findings were consistent with differences between East and West Berlin school systems. East Berlin regulations (a) emphasized public performance feedback and public self-evaluation and (b) enforced unidimensional teaching strategies. Results point to a risk factor for development in East Berlin children.

Children's action-control beliefs about school performance: how do American children compare with German and Russian children?

Using the revised Control, Agency, and Means-ends Interview (T. D. Little, G. Oettingen, & P. B. Baltes, 1995), we compared American children's (Grades 2-6) action-control beliefs about school performance with those of German and Russian children (Los Angeles, n = 657; East Berlin, n = 313; West Berlin, n = 517; Moscow, n = 541). Although we found pronounced cross-setting similarities in the children's everyday causality beliefs about what factors produce school performance, we obtained consistent cross-setting differences in (a) the mean levels of the children's personal agency and control expectancy and (b) the correlational magnitudes between these beliefs and actual school performance. Notably, the American children were at the extremes of the cross-national distributions: (a) they had the highest mean levels of personal agency and control expectancy but (b) the lowest beliefs-performance correlations. Such outcomes indicate that the low beliefs-performance correlations that are frequently obtained in American research appear to be specific to American settings.

On the incomplete architecture of human ontogeny. Selection, optimization, and compensation as foundation of developmental theory.

Drawing on both evolutionary and ontogenetic perspectives, the basic biological-genetic and social-cultural architecture of human development is outlined. Three principles are involved. First, evolutionary selection pressure predicts a negative age correlation, and therefore, genome-based plasticity and biological potential decrease with age. Second, for growth aspects of human development to extend further into the life span, culture-based resources are required at ever-increasing levels. Third, because of age-related losses in biological plasticity, the efficiency of culture is reduced as life span development unfolds. Joint application of these principles suggests that the life span architecture becomes more and more incomplete with age. Degree of completeness can be defined as the ratio between gains and losses in functioning. Two examples illustrate the implications of the life span architecture proposed. The first is a general theory of development involving the orchestration of 3 component processes: selection, optimization, and compensation. The second considers the task of completing the life course in the sense of achieving a positive balance between gains and losses for all age levels. This goal is increasingly more difficult to attain as human development is extended into advanced old age.

Wisdom. A metaheuristic (pragmatic) to orchestrate mind and virtue toward excellence.

The primary focus of this article is on the presentation of wisdom research conducted under the heading of the Berlin wisdom paradigm. Informed by a cultural-historical analysis, wisdom in this paradigm is defined as an expert knowledge system concerning the fundamental pragmatics of life. These include knowledge and judgment about the meaning and conduct of life and the orchestration of human development toward excellence while attending conjointly to personal and collective well-being. Measurement includes think-aloud protocols concerning various problems of life associated with life planning, life management, and life review. Responses are evaluated with reference to a family of 5 criteria: rich factual and procedural knowledge, lifespan contextualism, relativism of values and life priorities, and recognition and management of uncertainty. A series of studies is reported that aim to describe, explain, and optimize wisdom. The authors conclude with a new theoretical perspective that characterizes wisdom as a cognitive and motivational metaheuristic (pragmatic) that organizes and orchestrates knowledge toward human excellence in mind and virtue, both individually and collectively.

Sensory functioning and intelligence in old age: a strong connection.

Relations among age, sensory functioning (i.e., visual and auditory acuity), and intelligence were examined in a heterogeneous, age-stratified sample of old and very old individuals (N = 156, M age = 84.9 years, age range = 70-103). Intelligence was assessed with 14 tests measuring 5 cognitive abilities (speed, reasoning, memory, knowledge, and fluency). Together, visual and auditory acuity accounted for 49.2% of the total and 93.1% of the age-related reliable variance in intelligence. The data were consistent with structural models in which age differences in intelligence, including speed, are completely mediated by differences in vision and hearing. Results suggest that sensory functioning is a strong late-life predictor of individual differences in intellectual functioning. Explanations are discussed, including the possibility that visual and sensory acuity are indicators of the physiological integrity of the aging brain (common cause hypothesis).

Selection, optimization, and compensation as strategies of life management: correlations with subjective indicators of successful aging.

The usefulness of self-reported processes of selection, optimization, and compensation (SOC) for predicting on a correlational level the subjective indicators of successful aging was examined. The sample of Berlin residents was a subset of the participants of the Berlin Aging Study. Three domains (marked by 6 variables) served as outcome measures of successful aging: subjective well-being, positive emotions, and absence of feelings of loneliness. Results confirm the central hypothesis of the SOC model: People who reported using SOC-related life-management behaviors (which were unrelated in content to the outcome measures) had higher scores on the 3 indicators of successful aging. The relationships obtained were robust even after controlling for other measures of successful mastery such as personal life investment, neuroticism, extraversion, openness, control beliefs, intelligence, subjective health, or age.

Emergence of a powerful connection between sensory and cognitive functions across the adult life span: a new window to the study of cognitive aging?

Six hundred eighty seven individuals ages 25-103 years were studied cross-sectionally to examine the relationship between measures of sensory functioning (visual and auditory acuity) and intelligence (14 cognitive tasks representing a 5-factor space of psychometric intelligence). As predicted, the average proportion of individual differences in intellectual functioning connected to sensory functioning increased from 11% in adulthood (25-69 years) to 31% in old age (70-103 years). However, the link between fluid intellectual abilities and sensory functioning, albeit of different size, displayed a similarly high connection to age in both age groups. Several explanations are discussed, including a "common cause" hypothesis. In this vein, we argue that the increase in the age-associated link between sensory and intellectual functioning may reflect brain aging and that the search for explanations of cognitive aging phenomena would benefit from attending to factors that are shared between the 2 domains.

A systemic-wholistic view of psychological functioning in very old age: introduction to a collection of articles from the Berlin Aging Study.

Introduced are articles from the Berlin Aging Study (BASE) that collectively illustrate systemic-wholistic approaches to psychological functioning in old age. A systemic-wholistic perspective aims to elucidate structural and functional interdependencies between domains and to provide an integrative account of individual functioning. The special features of BASE (age range, 70-105 years; heterogeneous sample stratified by age and gender; and multidisciplinary data collection) are suited to this purpose. This article outlines the design of BASE, describes the cross-sectional sample (N = 516: 258 men and 258 women), and reports sample selectivity analyses on 25 criterion variables in which the Pearson-Lawley selection formulas were used. Although the BASE sample is positively biased, it is not restricted in heterogeneity and does not exhibit major differences in patterns of covariation among variables. This finding supports the use of BASE data for the intended systemic-wholistic analyses.

Intellectual functioning in old and very old age: cross-sectional results from the Berlin Aging Study.

This study documents age trends, interrelations, and correlates of intellectual abilities in old and very old age (70-103 years) from the Berlin Aging Study (N = 516). Fourteen tests were used to assess 5 abilities: reasoning, memory, and perceptual speed from the mechanic (broad fluid) domain and knowledge and fluency from the pragmatic (broad crystallized) domain. Intellectual abilities had negative linear age relations, with more pronounced age reductions in mechanic than in pragmatic abilities. Interrelations among intellectual abilities were highly positive and did not follow the mechanic-pragmatic distinction. Sociobiographical indicators were less closely linked to intellectual functioning than sensory-sensorimotor variables, which predicted 59% of the total reliable variance in general intelligence. Results suggest that aging-induced biological factors are a prominent source of individual differences in intelligence in old and very old age.

Profiles of psychological functioning in the old and oldest old.

Cluster analysis was applied to 12 measures of intellectual, personality, self-related, and social functioning collected in the 1st cross-sectional wave of the Berlin Aging Study (BASE; N = 516). Central questions concerned the number, profile desirability (functional status), and the membership of the subgroups obtained. Of the 9 subgroups extracted, 4 reflected different patterns of desirable functioning (47% of the sample), and 5 reflected less desirable functioning (53%). Relative risk of a less desirable profile was 2.5 times higher for the oldest old (85-103 years) than for people between the ages of 70-84 years and was 1.25 times higher for women compared with men. Relationships with education, health, and mortality suggested underlying systemic differences. Consistent with theoretical propositions about a "4th age" and the incomplete architecture of life span development (P.B. Baltes, 1997) the oldest old appear to have a distinct and less desirable psychological profile.

Professional expertise does not eliminate age differences in imagery-based memory performance during adulthood.

Using a testing-the-limits paradigm, the authors investigated the modulation (attenuation) of negative adult age differences in imagery-based memory performance as a function of professional expertise. Six older graphic designers, 6 normal older adults, 6 younger graphic design students, and 6 normal younger students participated in a 19-session program with a cued-recall variant of the Method of Loci. Older graphic designers attained higher levels of mnemonic performance than normal older adults but were not able to reach younger adults' level of performance; a perfect separation of age groups was achieved. Spatial visualization was a good predictor of mnemonic performance. Results suggest that negative adult age differences in imagery-based memory are attenuated but not eliminated by the advantages associated with criterion-relevant ability (talent) and experience.

The strong connection between sensory and cognitive performance in old age: not due to sensory acuity reductions operating during cognitive assessment.

Cognitive aging research has documented a strong increase in the covariation between sensory and cognitive functioning with advancing age. In part, this finding may reflect sensory acuity reductions operating during cognitive assessment. To examine this possibility, the authors administered cognitive tasks used in prior studies (e.g., Lindenberger & Baltes, 1994) to middle-aged adults under age-simulation conditions of reduced visual acuity, auditory acuity, or both. Visual acuity was lowered through partial occlusion filters, and auditory acuity through headphone-shaped noise protectors. Acuity manipulations reduced visual acuity and auditory acuity in the speech range to values reaching or approximating old-age acuity levels, respectively, but did not lower cognitive performance relative to control conditions. Results speak against assessment-related sensory acuity accounts of the age-related increase in the connection between sensory and cognitive functioning and underscore the need to explore alternative explanations, including a focus on general aspects of brain aging.

Wisdom-related knowledge in a life review task: age differences and the role of professional specialization.

The study adopts life review as an avenue to access wisdom-related knowledge and examines the contribution of age and type of professional specialization to individual differences in wisdom-related knowledge. Women from 2 age groups/cohorts (young, M = 32 years; old, M = 71 years) and different professional specializations (human services vs. nonhuman services) were asked to think aloud about the life review of a fictitious woman who was either young or old. Verbal protocols were scored on 5 wisdom-related criteria: factual and procedural knowledge about life, life-span contextualism, relativism of values, recognition, and management of uncertainty. Three major findings emerged. First, human-services professionals outperformed the control group. Second, old adults performed as well as young adults. Third, for older adults wisdom-related performance was enhanced by the match between their own age and the age of the fictitious character.

Memorizing while walking: increase in dual-task costs from young adulthood to old age.

The dual task of memorizing word lists while walking was predicted to become more difficult with age because balance and gait are in greater need of "attentional resources." Forty-seven young (ages 20-30 years), 45 middle-aged (40-50), and 48 old (60-70) adults were trained to criterion in a mnemonic technique and instructed to walk quickly and accurately on 2 narrow tracks of different path complexity. Then. participants encoded the word lists while sitting, standing, or walking on either track; likewise, speed and accuracy of walking performance were assessed with and without concurrent memory encoding. Dual-task costs increased with age in both domains; relative to young adults, the effect size of the overall increase was 0.98 standard deviation units for middle-aged and 1.47 standard deviation units for old adults. It is argued that sensory and motor aspects of behavior are increasingly in need of cognitive control with advancing age.

People nominated as wise: a comparative study of wisdom-related knowledge.

This study examined whether our conception of wisdom has a psychological bias, by focusing on a group of distinguished individuals nominated as being wise. The comparison groups included older clinical psychologists and highly educated old and young control groups. Wisdom-related knowledge was assessed by 2 tasks and evaluated with a set of 5 wisdom criteria. First, old wisdom nominees performed as well as clinical psychologists who in past research had shown the highest levels of performance. Second, wisdom nominees excelled in the task of existential life management and the criterion of value relativism. Third, up to age 80, older adults performed as well as younger adults. If there is a psychological bias to our conception of wisdom, this does not prevent nonpsychologists from being among the top performers.

The aging mind: potential and limits.

Research on the aging mind has moved from a simple growth vs decline view to a conception of a joint consideration of potential and limits. This development is illustrated by research on two categories of cognitive functioning: the cognitive mechanics and the cognitive pragmatics. The cognitive mechanics (comparable to fluid intelligence) are primarily determined by the evolution-based neurophysiological architecture of the mind, whereas the cognitive pragmatics (comparable to crystallized intelligence) primarily reflect the impact of culture. Testing-the-limits research on basic memory serves as a prototypical instantiation of the aging of cognitive mechanics; research on wisdom and the cognitive management of the self are prototypical examples of the aging of cognitive pragmatics. In the cognitive mechanics, as one would expect from a phenomenon which is largely genetically and biologically controlled, there is definite aging loss. Conversely, in the cognitive pragmatics, which is primarily culture-based, there is evidence for stability and positive change in persons who reach old age without specific brain pathology, and who live in favorable life circumstances. A model of successful aging, selective optimization with compensation, is presented to illustrate how individuals and societies might effectively manage the age-related shift toward a less positive balance between gains and losses and the associated dynamics between culture-based growth and biology-based decline in level of functioning.

Seeds of wisdom: adolescents' knowledge and judgment about difficult life problems.

The present study examined adolescents' wisdom-related knowledge and judgment with a heterogeneous sample of 146 adolescents (ages 14-20 years) and a comparison sample of 58 young adults (ages 21-37 years). Participants responded to difficult and ill-defined life dilemmas; expert raters evaluated these responses along 5 wisdom criteria. Our findings confirmed that in contrast to adulthood, adolescence is a major period for normative age-graded development in knowledge about difficult life problems. Adolescents performed at lower levels than young adults but also demonstrated substantial age increments in performance. As expected, adolescents' performance varied as a function of criterion and gender. These results hold implications for research on adolescent development and for the development of wisdom-related knowledge and judgment.