RESUMO
BACKGROUND: This meta-analysis aimed to consolidate existing data from randomised controlled trials on hypoplastic left heart syndrome. METHODS: Hypoplastic left heart syndrome specific randomised controlled trials published between January 2005 and September 2021 in MEDLINE, EMBASE, and Cochrane databases were included. Regardless of clinical outcomes, we included all randomised controlled trials about hypoplastic left heart syndrome and categorised them according to their results. Two reviewers independently assessed for eligibility, relevance, and data extraction. The primary outcome was mortality after Norwood surgery. Study quality and heterogeneity were assessed. A random-effects model was used for analysis. RESULTS: Of the 33 included randomised controlled trials, 21 compared right ventricle-to-pulmonary artery shunt and modified Blalock-Taussig-Thomas shunt during the Norwood procedure, and 12 regarded medication, surgical strategy, cardiopulmonary bypass tactics, and ICU management. Survival rates up to 1 year were superior in the right ventricle-to-pulmonary artery shunt group; this difference began to disappear at 3 years and remained unchanged until 6 years. The right ventricle-to-pulmonary artery shunt group had a significantly higher reintervention rate from the interstage to the 6-year follow-up period. Right ventricular function was better in the modified Blalock-Taussig-Thomas shunt group 1-3 years after the Norwood procedure, but its superiority diminished in the 6-year follow-up. Randomised controlled trials regarding medical treatment, surgical strategy during cardiopulmonary bypass, and ICU management yielded insignificant results. CONCLUSIONS: Although right ventricle-to-pulmonary artery shunt appeared to be superior in the early period, the two shunts applied during the Norwood procedure demonstrated comparable long-term prognosis despite high reintervention rates in right ventricle-to-pulmonary artery shunt due to pulmonary artery stenosis. For medical/perioperative management of hypoplastic left heart syndrome, further randomised controlled trials are needed to deliver specific evidence-based recommendations.
Assuntos
Procedimento de Blalock-Taussig , Síndrome do Coração Esquerdo Hipoplásico , Humanos , Síndrome do Coração Esquerdo Hipoplásico/cirurgia , Ponte Cardiopulmonar , Bases de Dados Factuais , Ventrículos do Coração/cirurgia , Ensaios Clínicos Controlados Aleatórios como AssuntoRESUMO
Coronary microperfusion assessment is a key parameter for understanding cardiac function. Currently, coronary ultrafast Doppler angiography is the only non-invasive clinical imaging technique able to assess coronary microcirculation quantitatively in humans. In this study, we propose to use fractional moving blood volume (FMBV), proportional to the red blood cell concentration, as a metric for perfusion. FMBV compares the power Doppler in a region of interest (ROI) inside the myocardium to the power Doppler of a reference area in the heart chamber, fully filled with blood. This normalization gives then relative values of the ROI blood filling. However, due to the impact of ultrasound attenuation and elevation focus on power Doppler values, the reference area and the ROI need to be at the same depth to allow this normalization. This condition is rarely satisfiedin vivodue to the cardiac anatomy. Hereby, we propose to locally compensate the attenuation between the ROI and the reference, by measuring the attenuation law on a phantom. We quantified the efficiency of this approach by comparing FMBV with and without compensation on a flow phantom. Compensated FMBV was able to estimate the ground-truth FMBV with less than 5% variation. This method was then adapted to thein vivocase of myocardial perfusion imaging during heart surgery on human neonates. The translation fromin vitrotoin vivorequired an additional clutter filtering step to ensure that blood signals could be correctly identified in the fast-moving myocardium. We applied the singular value decomposition filter on temporal sliding windows whose lengths were a function of myocardium motion. This motion-adaptive temporal sliding window approach was able to improve blood and tissue separation in terms of contrast-to-noise ratio, as compared to well-established constant-length sliding window approaches. Therefore, compensated FMBV and singular value decomposition assisted with motion-adaptive temporal sliding windows improves the quantification of blood volume in coronary ultrafast Doppler angiography.
Assuntos
Volume Sanguíneo , Ultrassonografia Doppler , Velocidade do Fluxo Sanguíneo , Angiografia Coronária , Humanos , Recém-Nascido , Imagens de Fantasmas , Ultrassonografia Doppler/métodosRESUMO
INTRODUCTION: Low cardiac output following cardiac surgery is a major determinant of outcome that may be improved by early detection, yet there are no widely accepted methods for its measurement in young children. We evaluated the feasibility of the routine use of electrical velocimetry, a non-invasive technique providing continuous measurement of cardiac output, in infants in the early postoperative period. METHODS: With ethical approval and parental consent, infants undergoing cardiac surgery were recruited. The ICON electrical velocimetry monitor was attached on admission to the intensive care unit (ICU) and remained for up to 24h. RESULTS: A total of 15 infants were recruited, median age 3 months (interquartile range (IQR) 0.5-7.5) and weight 4.8kg (IQR 3.9-7.1), undergoing various operations. Cardiac index had a weak correlation with arterial lactate (r=-0.24, p=0.02) and no correlation with blood pressure, central venous pressure or arteriovenous oxygen difference. Data were recorded for a median of 19h (range 5-24), with lead detachment or movement artefact the most common causes of data loss. There was marked minute-to-minute variability, with 25% of consecutive measurements having >5% variability. CONCLUSION: Cardiac index measured by electrical velocimetry in infants in the early postoperative period is impaired by frequent data loss and marked intrapatient variability. Our feasibility study suggests that it is unsuitable for use as a routine monitoring tool in the setting of postsurgical ICU care.
Assuntos
Procedimentos Cirúrgicos Cardíacos , Débito Cardíaco/fisiologia , Procedimentos Cirúrgicos Cardíacos/efeitos adversos , Criança , Pré-Escolar , Humanos , Lactente , Monitorização Fisiológica/métodos , Período Pós-Operatório , Reologia/métodosRESUMO
BACKGROUND: Hypoplastic left heart syndrome (HLHS) covers a spectrum of rare congenital anomalies characterised by a non-apex forming left ventricle and stenosis/atresia of the mitral and aortic valves. Despite many studies, the causes of HLHS remain unclear and there are conflicting views regarding the role of flow, valvar or myocardial abnormalities in its pathogenesis, all of which were proposed prior to the description of the second heart field. Our aim was to re-evaluate the patterns of malformation in HLHS in relation to recognised cardiac progenitor populations, with a view to providing aetiologically useful sub-groupings for genomic studies. RESULTS: We examined 78 hearts previously classified as HLHS, with subtypes based on valve patency, and re-categorised them based on their objective ventricular phenotype. Three distinct subgroups could be identified: slit-like left ventricle (24%); miniaturised left ventricle (6%); and thickened left ventricle with endocardial fibroelastosis (EFE; 70%). Slit-like ventricles were always found in combination with aortic atresia and mitral atresia. Miniaturised left ventricles all had normally formed, though smaller aortic and mitral valves. The remaining group were found to have a range of aortic valve malformations associated with thickened left ventricular walls despite being described as either atresia or stenosis. The degree of myocardial thickening was not correlated to the degree of valvar stenosis. Lineage tracing in mice to investigate the progenitor populations that form the parts of the heart disrupted by HLHS showed that whereas Nkx2-5-Cre labelled myocardial and endothelial cells within the left and right ventricles, Mef2c-AHF-Cre, which labels second heart field-derived cells only, was largely restricted to the endocardium and myocardium of the right ventricle. However, like Nkx2-5-Cre, Mef2c-AHF-Cre lineage cells made a significant contribution to the aortic and mitral valves. In contrast, Wnt1-Cre made a major contribution only to the aortic valve. This suggests that discrete cardiac progenitors might be responsible for the patterns of defects observed in the distinct ventricular sub-groups. CONCLUSIONS: Only the slit-like ventricle grouping was found to map to the current nomenclature: the combination of mitral atresia with aortic atresia. It appears that slit-like and miniature ventricles also form discrete sub-groups. Thus, reclassification of HLHS into subgroups based on ventricular phenotype, might be useful in genetic and developmental studies in investigating the aetiology of this severe malformation syndrome.
Assuntos
Fibroelastose Endocárdica/metabolismo , Fibroelastose Endocárdica/patologia , Cardiopatias Congênitas/metabolismo , Cardiopatias Congênitas/patologia , Síndrome do Coração Esquerdo Hipoplásico/metabolismo , Síndrome do Coração Esquerdo Hipoplásico/patologia , Animais , Ventrículos do Coração/metabolismo , Ventrículos do Coração/patologia , Proteína Homeobox Nkx-2.5/metabolismo , Imuno-Histoquímica , Fatores de Transcrição MEF2/metabolismo , Camundongos , Valva Mitral/metabolismo , Valva Mitral/patologia , Miocárdio/metabolismo , Miocárdio/patologiaRESUMO
OBJECTIVE: The purpose of the study was two-fold: (1) to highlight the varied presentation of mediastinal tuberculous lymphadenitis (MTL) in children and (2) to identify parameters, that may help in the early diagnosis of this condition. METHODS: Between January 1995 and December 2002, 13 children with histological diagnosis of MTL were retrospectively assessed for age at presentation, history of exposure to TB, presenting symptoms, investigations, initial diagnosis, surgical treatment and outcome. Stepwise multiple linear regression analysis was used to determine potential risk factors for early diagnosis of MTL. RESULTS: Thirteen children presented with: (a) fever, night sweats and weight loss (4); (b) acute respiratory distress (2); (c) cough and shortness of breath (SOB) (5); (d) stridor (1); and (e) chest pain (1). TB was suspected only in 6 children (46%) at presentation. In the other 7 cases (54%) the presumed diagnoses were: neuroblastoma (n=1), metastatic malignancy (n=1), bronchial polyp (n=1), bronchogenic cyst (n=2), and presumed foreign body (n=2). Bronchoscopy was diagnostic in identifying cheesy material within the bronchus and organisms on lavage in 4 (30%) and in identifying external compression in 2 (15%). Thoracotomy and excision of the lymph node mass was necessary to treat the mediastinal compression and to ascertain the diagnosis of TB in 3 children (23%). All 13 children had complete resolution of tuberculous lymphadenitis following anti-tuberculous treatment. The diagnostic clues in this cohort of patients were cough and SOB with history of exposure to tuberculosis (P=0.0001) and bronchoscopy and lavage with positive staining for acid-fast bacilli (P=0.0001). CONCLUSIONS: Tuberculosis was not suspected in 54% of children with MTL, and they posed diagnostic dilemma on admission. Bronchoscopy must be used as a diagnostic tool in children where tuberculosis cannot be excluded by radiology or specific skin tests. Thoracotomy and excision may be necessary to treat the obstructive symptoms.
Assuntos
Doenças do Mediastino/diagnóstico por imagem , Tuberculose dos Linfonodos/diagnóstico por imagem , Broncoscopia , Criança , Pré-Escolar , Diagnóstico Diferencial , Feminino , Humanos , Lactente , Masculino , Doenças do Mediastino/cirurgia , Tomografia Computadorizada por Raios X , Tuberculose dos Linfonodos/cirurgiaRESUMO
Recent evidence has suggested that competitive flow is an important factor in early graft failure. In this case report an internal thoracic artery graft was used to revascularize an acute coronary artery dissection after balloon angioplasty. Subsequent angiography 4 months later showed complete healing of the dissection, yet the internal thoracic artery graft remained widely patent in spite of the maximal competitive flow from the native coronary artery. This concurs with experimental results recently reported in The Annals regarding the physiologic adaptability of the internal thoracic artery graft to suit flow requirements and its versatility as the conduit of choice.
Assuntos
Adaptação Fisiológica , Velocidade do Fluxo Sanguíneo , Ponte de Artéria Coronária , Artérias Torácicas/fisiologia , Artérias Torácicas/transplante , Grau de Desobstrução Vascular , Feminino , Humanos , Pessoa de Meia-Idade , Radiografia , Artérias Torácicas/diagnóstico por imagemRESUMO
A variety of approaches and surgical techniques have been described for the management of recurrent coarctation. When there is an additional intracardiac defect that requires surgical correction it is preferable to correct both lesions simultaneously and through the same incision. This article reports two new techniques of connecting ascending to descending aorta using an intrathoracic conduit and performed through a median sternotomy.
Assuntos
Aorta/cirurgia , Coartação Aórtica/cirurgia , Coartação Aórtica/complicações , Prótese Vascular , Pré-Escolar , Comunicação Interventricular/complicações , Humanos , Masculino , Recidiva , Reoperação , Aderências Teciduais , Procedimentos Cirúrgicos Vasculares/métodosRESUMO
BACKGROUND: Atrophy and fibrosis of the distal part of the latissimus dorsi muscle (LDM) wrap is a recognized complication of cardiomyoplasty that has been attributed to ischemia. Failure of the muscle wrap contributes to the late attrition seen in clinical cardiomyoplasty. In this study we examined the role of two-staged mobilization and of preconditioning by electrical stimulation on the regional perfusion and oxygenation of the LDM. METHODS: In a rabbit model (n = 36) the LDM was preconditioned as follows: group A muscles received preconditioning in situ; group B muscles were partially mobilized by dividing the intercostal perforators and then preconditioned; and group C muscles were completely mobilized and wrapped around a silicone-rubber mandrel before conditioning. Controls received no conditioning. The preconditioning regimen consisted of 2 weeks of continuous stimulation at 2.5 Hz. At completion of preconditioning the muscles were fully mobilized and mounted on a muscle-testing apparatus. Purpose-built microelectrodes measured regional PO2 and perfusion using a diffusible gas tracer technique. Muscles were weighed and processed for fiber typing and capillary counting. RESULTS: All preconditioned muscles demonstrated fiber transformation, with increased fatigue resistance. Perfusion of preconditioned muscles both at rest and during contraction was higher than control in the proximal part of the muscle. Distal regions of group B muscles had higher perfusion and capillary density than any other group (p < 0.05). Distal regions of group C had the lowest perfusion and capillary density, and showed muscle atrophy and histologic evidence of necrosis. During fatigue testing there was a decrease in the PO2 in the distal regions of the control and group C muscles (p < 0.05), whereas it was maintained at resting levels in both group A and B muscles. CONCLUSIONS: Conditioning in situ improves perfusion of the distal LDM and prevents a fall in tissue PO2 during contraction. Two-stage mobilization further improves distal perfusion and capillary density. In contrast, shortterm elevation followed by conditioning produces impaired distal perfusion, decrease in PO2, and fiber necrosis in the distal muscle. The present study suggests that partial mobilization of the LDM performed at the same time as placement of electrodes for preconditioning may prepare the LDM better for the demands of cardiomyoplasty.
Assuntos
Cardiomioplastia/métodos , Ventrículo de Músculo Esquelético , Retalhos Cirúrgicos , Animais , Estimulação Elétrica/instrumentação , Desenho de Equipamento , Masculino , Oxigênio/metabolismo , Cuidados Pré-Operatórios , Coelhos , Fluxo Sanguíneo Regional , Ventrículo de Músculo Esquelético/fisiologia , Fatores de TempoRESUMO
We describe two patients who both suffered a cardiac arrest whilst maintained on an intra-aortic balloon pump. In an attempt to improve coronary and cerebral blood flow during cardiopulmonary resuscitation, the intra-aortic balloon was inflated to occlude the descending aorta and preferentially direct blood to the cerebral and coronary circulation. In case 1, mean radial artery pressure rose from 71/14 mmHg (mean = 33 mmHg) to 92/24 mmHg (mean = 47 mmHg). Diastolic right atrial pressure was 16 mmHg both with the balloon deflated and inflated. In patient 2, mean radial artery pressure rose from 48/21 mmHg (mean = 25 mmHg) to 62/26 mmHg (mean = 36 mmHg). Right atrial pressure was 90/6 mmHg (mean 34 mmHg) with the balloon deflated and 104/8 mmHg (mean = 40 mmHg) with the balloon inflated. Coronary artery perfusion pressure in case 1 increased from -2 to 8 mmHg and in case 2 increased from 15 to 18 mmHg. These results suggest that occlusion of the descending aorta during cardiac massage may improve coronary and cerebral perfusion pressures. Animal studies are consistent with these findings and show that aortic occlusion may significantly improve outcome from cardiac arrest.
Assuntos
Reanimação Cardiopulmonar , Parada Cardíaca/fisiopatologia , Parada Cardíaca/terapia , Hemodinâmica/fisiologia , Balão Intra-Aórtico , Aorta Torácica , Feminino , Humanos , Masculino , Pessoa de Meia-IdadeRESUMO
OBJECTIVE: In repair of truncus arteriosus the accepted methods of establishing right ventricle (RV) to pulmonary artery (PA) continuity utilize an allograft or xenograft valved conduit. Alternatively, the PA confluence may be directly anastomosed to the RV with anterior patch augmentation, which may allow growth and delay or avoid subsequent RVOT obstruction. These methods of RVOT reconstruction were evaluated in infants undergoing truncus arteriosus repair. METHODS: A retrospective analysis of 61 infants undergoing repair of truncus arteriosus between November 1988 and June 2000 was performed. Median age was 34 days (range 1 day to 6.4 months). The patient cohort was subdivided into two groups (1) Valved conduit group: RV to PA continuity performed with a conduit in 38 patients using allograft (28) or xenograft (10). (2) Direct anastomosis group: direct RV-PA anastomosis performed in 23 patients, augmented anteriorly with monocusp (15) or simple pericardial patch (eight). RESULTS: There were eight hospital deaths (13%, 95% confidence limits 5--21%). Hospital mortality did not differ significantly between group 1 and 2 (three patients (8%) versus five patients (22%) respectively, P=0.23). By multivariate analysis, low operative weight (P=0.023), severe truncal regurgitation (P=0.022) and major coronary abnormalities (P=0.018), were independent risk factors for hospital death. Hospital survivors were followed-up from 1.3 months to 11.8 years (mean 4.2+/-3.4 years). There were eight late deaths with survival of 73+/-6% at 2 years and beyond. Survival was not influenced by method of RVOT reconstruction (Conduit versus direct RV-PA anastomosis, 2.76+/-7%, 63+/-10%, respectively, P=0.23). Freedom from surgical RVOT reintervention was 56+/-10% in group 1 and 89+/-10% in group 2 at 10 years (P=0.023). The use of a xenograft conduit was an independent risk factor for reintervention (P<0.001). CONCLUSIONS: In truncus arteriosus repair, RV to PA continuity established by a direct anastomosis was associated with a low incidence of surgical RVOT re-intervention. This technique has the potential for RVOT growth and may be a useful alternative when an appropriate allograft is unavailable, particularly in the neonate where the risk of pulmonary hypertension are lower.
Assuntos
Persistência do Tronco Arterial/cirurgia , Obstrução do Fluxo Ventricular Externo/cirurgia , Implante de Prótese Vascular , Procedimentos Cirúrgicos Cardíacos/métodos , Estudos de Casos e Controles , Feminino , Mortalidade Hospitalar , Humanos , Lactente , Masculino , Complicações Pós-Operatórias/epidemiologia , Reoperação/estatística & dados numéricos , Resultado do TratamentoRESUMO
OBJECTIVE: Antibiotic-sterilised homograft valves stored at 4 degrees C have been implanted in the subcoronary position in this unit since 1973. This study was undertaken in order to assess the long-term function of these valves. METHODS: All 249 patients undergoing homograft aortic valve replacement (AVR) at the Wessex Cardiothoracic Centre between April 1973 and December 1994 were studied. Homograft valve sizes ranged from 15 mm to 28 mm internal diameter, 202 (81.1%) varying between 18 mm and 22 mm. The mean patient follow-up was 12.4 years with a total follow-up of 3096 patient-years. There were six early deaths (2.4%). RESULTS: On actuarial analysis, survival was 78.5+/-2.7% (1SE) at 10 years, 65.7+/-3.3% at 15 years and 55.0+/-3.9% at 20 years. The freedom from redo AVR was 87.9+/-2.4% at 10 years, 71.7 +/-3.8% at 15 years and 49.7+/-5.6% at 20 years. The freedom from structural degeneration was 85.6+/-2.5% at 10 years, 63.6+/-4.0% at 15 years and 41.9+/-6.4% at 20 years. On multivariate analysis the risk of valve failure was significantly higher in younger patients (P<0.0001) and in those who underwent aortic root tailoring (P = 0.024). The freedom from endocarditis was 98.4+/-0.9% at 10 years, 96.2+/-1.6% at 15 years and 95.1+/-1.9% at 20 years. Of the 249 patients, 218 had an isolated homograft AVR and were not anticoagulated. In this group there were two possible thromboembolic events. CONCLUSION: As well as the established haemodynamic benefits, this study has shown that homograft AVR with antibiotic-sterilised 4 degrees C stored homograft valves implanted in the subcoronary position, offers good long-term results.
Assuntos
Antibacterianos , Valva Aórtica/transplante , Quimioterapia Combinada/farmacologia , Implante de Prótese de Valva Cardíaca/métodos , Esterilização/métodos , Preservação de Tecido/métodos , Adolescente , Adulto , Idoso , Idoso de 80 Anos ou mais , Criança , Feminino , Seguimentos , Doenças das Valvas Cardíacas/cirurgia , Implante de Prótese de Valva Cardíaca/mortalidade , Humanos , Masculino , Pessoa de Meia-Idade , Complicações Pós-Operatórias/mortalidade , Estudos Retrospectivos , Taxa de Sobrevida , Transplante Homólogo , Resultado do TratamentoRESUMO
BACKGROUND: In the clinical application of transformed skeletal muscle to cardiac assistance there is evidence that the latissimus dorsi muscle (LDM) wrap can undergo atrophy, which would prevent it from providing a sustained functional improvement. Possible causes are ischaemia and degeneration related to the conditioning process. We studied the nutritional and structural changes occurring under different stimulation regimes with the aim of improving the conditioning protocol. METHODS: Microelectrodes were used to measure regional perfusion and oxygenation in the rabbit LDM during mobilisation and subsequent repeated contraction. Group A muscles (n = 10) were conditioned for 6 weeks at 10 Hz, Group B muscles (n = 10) for 2 weeks at 2.5 Hz. Each muscle was then mobilised and tested in a hydraulic apparatus which recorded the pressure generated in a closed circuit. RESULTS: Muscles of Group A and Group B demonstrated transformation of fibre type, with a predominance of type I (62 +/- 4%) fibres in Group A and type IIa (68 +/- 9%) fibres in Group B. There was no evidence of muscle degeneration. After 10 min of fatigue testing the pressure produced was 53 +/- 5% of initial values in Group A and 51 +/- 8% in Group B, compared to 8 +/- 1% in the control group (P < 0.001). Maximum rate of relaxation was faster in Group B than in Group A (46 +/- 3% vs. 36 +/- 3% of control muscle, P < 0.05). Mobilisation resulted in a decrease in the distal perfusion of the control muscles (P < 0.05) and PO2 decreased by 8.7 +/- 1.7 mmHg during a fatigue test, which resulted in rapid loss of contractile function to 46 +/- 1% of the initial value within 1 min. In both Groups A and B the perfusion of all regions of the muscles both before and after mobilisation was greater than that of controls. During the same fatigue test, the PO2 of the distal regions was maintained and the contractile function fell more slowly to between 70 and 80% of initial values within 1 min. CONCLUSION: We showed that ischaemia in the distal region of the control LDM could result from mobilisation and repeated contraction. Muscle transformation improved perfusion and prevented a fall in tissue PO2 during a sustained series of contractions. Muscles that were conditioned at 2.5 Hz shared the improved perfusion of the fully transformed muscle, but had faster relaxation characteristics. Short periods of in situ conditioning prior to mobilisation may help to avoid ischaemic changes in distal parts of the LDM while achieving fatigue resistance in the grafted muscle at an earlier postoperative stage.
Assuntos
Cardiomioplastia , Contração Muscular , Fadiga Muscular , Oxigênio/sangue , Ventrículo de Músculo Esquelético/fisiologia , Animais , Estimulação Elétrica , Imuno-Histoquímica , Técnicas In Vitro , Masculino , Fibras Musculares Esqueléticas/citologia , Cadeias Pesadas de Miosina/metabolismo , Tamanho do Órgão , Coelhos , Ventrículo de Músculo Esquelético/irrigação sanguínea , Ventrículo de Músculo Esquelético/patologia , Succinato Desidrogenase/metabolismo , Condicionamento Pré-TransplanteRESUMO
In conventional surgery for the associated lesions of congenitally corrected transposition of the great arteries, the right ventricle remains in the systemic circulation. In this situation, the right ventricle and tricuspid valve fail in an unpredictable manner. The double switch procedure was introduced to restore the morphologic left ventricle to the systemic circulation and considerable success has been seen over the last 10 years with this approach. The Rastelli and atrial switch procedure can be applied to patients with congenitally corrected transposition of the great arteries and pulmonary stenosis or atresia and a suitably placed ventricular septal defect in the outlet septum of the ventricle beneath the aortic valve. Thus, the left ventricle can be restored to the systemic circulation. The Rastelli-atrial switch is a complex operative procedure, but the operative risk and long-term results are good without evidence in the mid-term of ventricular failure as has been associated with the conventional repair. A disadvantage is that these patients require valved conduit changes over the years.
Assuntos
Procedimentos Cirúrgicos Cardíacos/métodos , Comunicação Interventricular/cirurgia , Atresia Pulmonar/cirurgia , Estenose da Valva Pulmonar/cirurgia , Transposição dos Grandes Vasos/cirurgia , Anormalidades Múltiplas/diagnóstico , Anormalidades Múltiplas/cirurgia , Anormalidades Cardiovasculares/diagnóstico , Anormalidades Cardiovasculares/cirurgia , Feminino , Comunicação Interventricular/complicações , Comunicação Interventricular/diagnóstico , Humanos , Lactente , Masculino , Ciência de Laboratório Médico , Seleção de Pacientes , Cuidados Pós-Operatórios , Prognóstico , Atresia Pulmonar/complicações , Atresia Pulmonar/diagnóstico , Estenose da Valva Pulmonar/complicações , Estenose da Valva Pulmonar/diagnóstico , Medição de Risco , Transposição dos Grandes Vasos/complicações , Transposição dos Grandes Vasos/diagnóstico , Resultado do Tratamento , Procedimentos Cirúrgicos Vasculares/métodosRESUMO
Visible light-cured (VLC) denture resins are relatively new products used for the reline and repair of dentures. The conversion of monomer into polymer in 3 brands of visible light-cured denture resins was investigated. The relationship of the inorganic filler content to this conversion was also studied. It was determined that these reline materials vary in monomer conversion and weight percentage of filler, and this variation is brand dependent. The monomer conversion ranged from 77% to 97%. Significant differences in these values were found when duration of light exposure was increased. In addition, resin nearest to the light source polymerized to a greater extent when compared to resin that was 1 mm deep to this surface, hence furthest from the light source. The inorganic filler content ranged from 0% to 15%. For the resin systems studied, the relationship between monomer conversion and inorganic filler loading was inversely proportional. Results indicated that monomer conversion of VLC repair resins was affected by the duration of light exposure as well as the amount of inorganic filler present in the material.
Assuntos
Resinas Acrílicas/química , Bases de Dentadura , Metacrilatos/química , Análise de Variância , Luz , Teste de MateriaisRESUMO
BACKGROUND: Palliative staged reconstructive surgery has radically altered the outcome of babies with hypoplastic left heart syndrome (HLHS). AIM: To compare the current outcome of antenatally diagnosed HLHS with a series 5 years previously now that paediatric cardiothoracic and postnatal paediatric intensive care techniques have been further refined. METHOD: Comparison of all cases of HLHS diagnosed antenatally at Birmingham Women's Hospital between 1 January 2000 and 31 December 2004 with results of the previous series. RESULTS: 79 fetuses were identified with HLHS. The median gestational age at diagnosis was 22 weeks. After counselling, 20 (25.3%) couples terminated the pregnancy compared with 43.7% in the previous cohort (p = 0.01). Of the 59 couples who continued with the pregnancy, four had stillbirths and two were lost to follow-up. Subsequently, there were 53 live births, of which six babies had an alternative major congenital heart disease diagnosed postnatally; 10 babies were not considered for surgery (parents' wishes) and died after compassionate care; 31 babies underwent surgery. The early (30 days) surgical mortality after stage 1 Norwood procedure was 19.4% and 20 patients are still alive. In the cohort of intention-to-treat cases, the overall survival was 46.9% (23/49). CONCLUSION: The number of parents choosing termination after an antenatal diagnosis of HLHS has almost halved since 5 years ago. Despite the significant increase in surgical survival following stage 1 Norwood in this period, in the intention-to-treat cohort the survival was 46.9%. These data again highlight the poorer outcome for babies with congenital malformations diagnosed in utero in comparison with those identified postnatally.
Assuntos
Aborto Eugênico/estatística & dados numéricos , Síndrome do Coração Esquerdo Hipoplásico/mortalidade , Síndrome do Coração Esquerdo Hipoplásico/cirurgia , Inglaterra , Feminino , Doenças Fetais/diagnóstico , Doenças Fetais/mortalidade , Doenças Fetais/terapia , Humanos , Síndrome do Coração Esquerdo Hipoplásico/diagnóstico , Gravidez , Resultado da Gravidez , Diagnóstico Pré-Natal , Prognóstico , Análise de Sobrevida , Resultado do TratamentoRESUMO
OBJECTIVE: To describe a 12 year experience with staged surgical management of the hypoplastic left heart syndrome (HLHS) and to identify the factors that influenced outcome. METHODS: Between December 1992 and June 2004, 333 patients with HLHS underwent a Norwood procedure (median age 4 days, range 0-217 days). Subsequently 203 patients underwent a bidirectional Glenn procedure (stage II) and 81 patients underwent a modified Fontan procedure (stage III). Follow up was complete (median interval 3.7 years, range 32 days to 11.3 years). RESULTS: Early mortality after the Norwood procedure was 29% (n = 95); this decreased from 46% (first year) to 16% (last year; p < 0.05). Between stages, 49 patients died, 27 before stage II and 22 between stages II and III. There were one early and three late deaths after stage III. Actuarial survival (SEM) was 58% (3%) at one year and 50% (3%) at five and 10 years. On multivariable analysis, five factors influenced early mortality after the Norwood procedure (p < 0.05). Pulmonary blood flow supplied by a right ventricle to pulmonary artery (RV-PA) conduit, arch reconstruction with pulmonary homograft patch, and increased operative weight improved early mortality. Increased periods of cardiopulmonary bypass and deep hypothermic circulatory arrest increased early mortality. Similar factors also influenced actuarial survival after the Norwood procedure. CONCLUSION: This study identified an improvement in outcome after staged surgical management of HLHS, which was primarily attributable to changes in surgical technique. The RV-PA conduit, in particular, was associated with a notable and independent improvement in early and actuarial survival.
Assuntos
Síndrome do Coração Esquerdo Hipoplásico/cirurgia , Ponte Cardiopulmonar/métodos , Ponte Cardiopulmonar/mortalidade , Técnica de Fontan/métodos , Técnica de Fontan/mortalidade , Humanos , Síndrome do Coração Esquerdo Hipoplásico/mortalidade , Lactente , Análise Multivariada , Análise de SobrevidaRESUMO
UNLABELLED: The 3-year survival after small bowel transplantation (SBTx) has improved to between 73% and 88%. Impaired venous access for parenteral nutrition can be an indication for SBTx in children with chronic intestinal failure. AIM: To report our experience in management of children with extreme end-stage venous access. SUBJECTS: The study consisted of 6 children (all boys), median age of assessment 27 months (range, 13-52 months), diagnosed with total intestinal aganglionosis (1), protracted diarrhea (1), and short bowel syndrome (4), of which gastroschisis (2) and malrotation with midgut volvulus (2) were the causes. All had a documented history of more than 10 central venous catheter insertions previously. All had venograms, and 1 child additionally had a magnetic resonance angiogram to evaluate venous access. Five of 6 presented with thrombosis of the superior vena cava (SVC) and/or inferior vena cava. METHODS: Venous access was reestablished as follows: transhepatic venous catheters (5), direct intra-atrial catheter via midline sternotomy (4), azygous venous catheters (2), dilatation of left subclavian vein after passage of a guide wire and then placing a catheter to reach the right atrium (1), radiological recanalization of the SVC and placement of a central venous catheter in situ (1), and direct puncture of SVC stump(1). Complications included serous pleural effusion after direct intra-atrial line insertion, which resolved after chest drain insertion (1), displacement of transhepatic catheter needing repositioning (2), and SVC stent narrowing requiring repeated balloon dilatation. OUTCOME: Four children with permanent intestinal failure on assessment were offered SBTx, 3 of which were transplanted and were established on full enteral nutrition; the family of 1 child declined the procedure. In the remaining 2 children in whom bowel adaptation was still a possibility, attempts were made to provide adequate central venous access as feeds and drug manipulations were undertaken. One of them received liver and SBTx nearly 3 years after presenting with end-stage central venous access, because attempts to achieve independence from parenteral nutrition had failed. The other child died immediately after a transhepatic venous catheter placement, possibly from a nutritional depletion syndrome as no physical cause of death was found. Direct intra-atrial catheters in transplanted children proved to be adequate for the management of uncomplicated transplantation, although the usual infusion protocol had to be modified considerably, and the lack of access would have been critical if massive blood transfusion had been required during the transplant procedure. CONCLUSION: It was possible to reestablish central venous access in all cases. However, this was time consuming and difficult to assemble a skilled team consisting of one of more: surgeon, cardiologist, interventional radiologist, and transplant anesthetist. Small bowel transplantation is easier and safer with adequate central venous access, and we advocate liaison with an SBTx center at an early stage.
Assuntos
Cateterismo Venoso Central/efeitos adversos , Cateterismo Venoso Central/instrumentação , Cateteres de Demora , Intestino Delgado/irrigação sanguínea , Intestino Delgado/transplante , Cateterismo Venoso Central/métodos , Pré-Escolar , Falha de Equipamento , Humanos , Lactente , Masculino , Nutrição Parenteral , Trombose/etiologia , Resultado do TratamentoRESUMO
OBJECTIVES: To review 13 years' data from a unit for grown ups with congenital heart disease (GUCH) to understand the change in surgical practice. METHODS: Records were reviewed of patients over 16 years of age undergoing surgery between 1 January 1990 and 31 December 2002 in a dedicated GUCH unit. Patients with atrial septal defects were included but not those with Marfan's syndrome or undergoing a first procedure for bicuspid aortic valves. Three equal time periods of 52 months were analysed. RESULTS: Of 474 operations performed, 162 (34.2%) were repeat operations. The percentage of repeat operations increased from 24.8% (41 of 165) in January 1990-April 1994 to 49.7% (74 of 149) in September 1998-December 2002. Mortality was 6.3% (n = 30). The median age decreased from 25.4 years (interquartile range 18.7) in January 1990-April 1994 to 23.9 (interquartile range 17.3) in September 1998-December 2002 (p = 0.04). The proportion of patients with a "simple" diagnosis decreased from 45.4% (74 or 165) in January 1990-April 1994 to 27.5% (41 of 149) in September 1998-December 2002 (p = 0.013). Pulmonary valve replacements in operated tetralogy of Fallot increased from one case in January 1990-April 1994 to 23 cases in September 1998-December 2002 and conduit replacement increased from five cases to 17. However, secundum atrial septal defect closures decreased from 35 cases to 14 (p < 0.0001). The estimated cost (not including salaries and prosthetics) incurred by an adult patient with congenital heart disease was pound2290 compared with pound2641 for a patient undergoing coronary artery bypass grafting. CONCLUSION: Despite the impact of interventional cardiology, the total number of surgical procedures remained unchanged. The complexity of the cases increased particularly with repeat surgery. Nevertheless, the patients do well with low mortality and the inpatient costs remain comparable with costs of surgery for acquired disease.
Assuntos
Cardiopatias Congênitas/cirurgia , Prática Profissional/tendências , Adolescente , Adulto , Idoso , Implante de Prótese Vascular/economia , Implante de Prótese Vascular/estatística & dados numéricos , Implante de Prótese Vascular/tendências , Custos e Análise de Custo , Inglaterra , Cardiopatias Congênitas/economia , Humanos , Tempo de Internação/economia , Pessoa de Meia-Idade , Prática Profissional/economia , Reoperação/economia , Reoperação/estatística & dados numéricos , Reoperação/tendências , Carga de Trabalho/estatística & dados numéricosRESUMO
Recent observations suggest that the diverse actions of the insulin-like growth factors (IGFs) are the result of interactions of the various components that make up the IGF system. The components of this system include IGF-I and -II and their variants, the type 1 and 2 IGF receptors and the insulin-like growth factor binding proteins (IGFBPs). Various components of the IGF system are expressed in the developing mouse embryo and the adjacent tissues of the reproductive tract in which the embryo develops. Thus there is the potential for paracrine interactions between the maternal and fetal tissues. Transcripts for the IGF receptors, IGF-I and IGF-II, have been demonstrated in the periimplantation mouse embryo. While there are now data from gene ablation experiments indicating that IGF-II is important in embryogenesis, the role of other components of the IGF system such as the IGFBPs remains unclear. The data accumulated so far are largely empirical, and there is as yet little compelling evidence that maternal IGFs derived from oviduct or uterine fluid and maternal tissues are necessary for normal fetal development. We have started to develop transgenic mice lines overexpressing IGFBPs to attempt to address the role of these binding proteins in fetal development.