RESUMO
The main goals of acetabular fracture management are to restore the congruity and stability of the hip joint. These goals are the same for all patients who have an acetabular fracture, regardless of the morphology or etiology of the fracture. Nevertheless, certain acetabular fracture types and several patient factors pose management challenges for surgeons. Therefore, surgeons who manage acetabular fractures must understand the distinctive features of acetabular fractures as well as the soft-tissue and patient-related factors that play a critical role in patient outcomes. Particular challenges in the management of acetabular fractures include acetabular fracture types that involve the posterior wall, acetabular fractures with soft-tissue concerns, acetabular fractures in patients with multiple injuries, and acetabular fractures in the geriatric population. Although the well-known protocols that were established by Judet and Letournel continue to be important guidelines for the management of acetabular fractures, the injury characteristics of acetabular fractures, the demographics of the patients in whom acetabular fractures occur, and the treatment options for acetabular fractures have evolved. Therefore, surgeons must be aware of new and more recently published information on acetabular fractures.
Assuntos
Acetábulo , Fraturas Ósseas , Acetábulo/lesões , Idoso , Fraturas Ósseas/cirurgia , Humanos , Tomografia Computadorizada por Raios XRESUMO
Rocker bottom shoes are commonly recommended for patients who have undergone ankle arthrodesis. Limited data are available to support this recommendation. In the present case-control study, 2 groups of participants were identified for the investigation: a study group (SG) of 9 patients who had previously undergone ankle arthrodesis and a normal group (NG) of 9 healthy volunteers. Gait data were collected using a video recorder while the participants walked barefoot and wearing rocker bottom shoes. These data were analyzed using computer-based gait analysis software. The total motion was calculated and averaged for each group for walking barefoot and wearing rocker bottom shoes. All participants completed the Short Musculoskeletal Function Assessment and the American Orthopaedic Foot and Ankle Society questionnaires. The total motion of the SG wearing rocker bottom shoes increased 4.8° (range 3.4° to 6.9°) on mean average, an improvement compared with walking barefoot (p < .05). In the NG, the shoe wear had no effect on the total motion (p = .59). Although the total motion in the SG approached the mean average of the total motion of the NG, it remained significantly less than that of the NG (p < .05). Additionally, the SG scored worse than the NG on both outcomes questionnaires (p < .05). Rocker bottom shoes had no effect on gait velocity. In conclusion, rocker bottom shoes significantly improve the total motion of ankle arthrodesis patients toward normal.
Assuntos
Traumatismos do Tornozelo/complicações , Articulação do Tornozelo/cirurgia , Artrite/cirurgia , Artrodese , Marcha/fisiologia , Sapatos , Adulto , Idoso , Traumatismos do Tornozelo/reabilitação , Articulação do Tornozelo/fisiopatologia , Artrite/etiologia , Artrite/fisiopatologia , Desenho de Equipamento , Feminino , Seguimentos , Humanos , Masculino , Pessoa de Meia-Idade , Período Pós-Operatório , Estudos Retrospectivos , Fatores de Tempo , Resultado do TratamentoRESUMO
Several factors can affect the magnitude of eccentric exercise (ECC)-induced muscle damage, but little is known regarding the effect of the range of motion (ROM) in ECC-induced muscle damage. The purpose of this study was to investigate whether elbow flexor ECC with 120° of ROM (from 60° of elbow flexion until elbow full extension - 180° [120ROM]) induces a greater magnitude of muscle damage compared with a protocol with 60° of ROM (120-180° of elbow flexion [60ROM]). Twelve healthy young men (age: 22 ± 3.1 years; height: 1.75 ± 0.05 m; body mass: 75.6 ± 13.6 kg) performed the ECC with 120ROM and 60ROM using different arms in a random order separated by 2 weeks and were tested before and 24, 48, 72 and 96 h after ECC for maximal voluntary isometric contraction torque (MVC-ISO), ROM and muscle soreness. The 120ROM protocol showed greater changes and effect sizes (ES) for MVC-ISO (-35%, ES: 1.97), ROM (-11.5°, ES: 1.27) and muscle soreness (19 mm, ES: 1.18) compared with the 60ROM protocol (-23%, ES: 0.93; -12%, ES: 0.56; 17°, ES: 0.63; 8 mm, ES: 1.07, respectively). In conclusion, ECC of the elbow flexors with 120° of ROM promotes a greater magnitude of muscle damage compared with a protocol with 60° of ROM, even when both protocols are performed at long muscle lengths.
RESUMO
The general goals for treating an acetabular fracture are to restore congruity and stability of the hip joint. These goals are no different from those for the subset of fractures of the posterior wall. Nevertheless, posterior wall fractures present unique problems compared with other types of acetabular fractures. Successful treatment of these fractures depends on a multitude of factors. The physician must understand their distinctive radiologic features, in conjunction with patient factors, to determine the appropriate treatment. By knowing the important points of posterior surgical approaches to the hip, particularly the posterior wall, specific techniques can be used for fracture reduction and fixation in these often challenging fractures. In addition, it is important to develop a complete grasp of potential complications and their treatment. The evaluation and treatment protocols initially developed by Letournel and Judet continue to be important; however, the surgeon also should be aware of new information published and presented in the past decade.
Assuntos
Acetábulo/lesões , Gerenciamento Clínico , Fixação de Fratura/métodos , Fraturas Ósseas/cirurgia , Acetábulo/cirurgia , HumanosRESUMO
BACKGROUND: The regional mandatory care is a central element of psychiatric treatment in Germany. Therefore, it is possible to realize care near to the place of residence of psychiatric patients and good contact to the outpatient health system. Up to now the new payment system in psychiatry in Germany does not explicitly include this central factor. AIM: The article investigates which criteria possibly describe psychiatric mandatory care and whether they can be ascertained from routine data. MATERIAL: The results are based on the so-called § 21 records of 47 psychiatric and psychosomatic clinics all of which participated in the German VIPP (healthcare indicators in psychiatry and psychosomatics) project. It is obligatory to send the standardized § 21 record to the Institute for the Hospital Remuneration System (InEK) annually. RESULTS: The study identified two factors which could describe clinics with regional mandatory care. Many patients attend these hospitals outside the core time of Monday to Friday, 8 am to 5 pm and the distance to their place of residence is shorter. This is associated with a higher day-related valuation, the so-called day mix index (DMI). DISCUSSION: Routine data contain information describing regional mandatory psychiatric care. Patients treated in this system show a higher DMI. This means higher proceeds for the hospitals but it is not clear if these proceeds are able to cover the higher costs in clinics with regional mandatory care. Therefore, it is necessary for the InEK to set up a new cost center for all clinics which participate as a so-called calculation site. By posting all structural costs of mandatory care in this cost center it will be possible to compare them with the income of psychiatric clinics in the future.
Assuntos
Internação Compulsória de Doente Mental/estatística & dados numéricos , Serviços Comunitários de Saúde Mental/estatística & dados numéricos , Acessibilidade aos Serviços de Saúde/estatística & dados numéricos , Hospitais Psiquiátricos/estatística & dados numéricos , Transtornos Mentais/epidemiologia , Sistema de Registros , Adulto , Idoso , Feminino , Alemanha/epidemiologia , Humanos , Masculino , Programas Obrigatórios , Transtornos Mentais/diagnóstico , Transtornos Mentais/terapia , Pessoa de Meia-Idade , Psicoterapia , Revisão da Utilização de Recursos de Saúde , Adulto JovemRESUMO
BACKGROUND: A single iliosacral screw placed into the S1 vertebral body has been shown to be clinically unreliable for certain type C pelvic ring injuries. Insertion of a second supplemental iliosacral screw into the S1 or S2 vertebral body has been widely used. However, clinical fixation failures have been reported using this technique, and a supplemental long iliosacral or transsacral screw has been used. The purpose of this study was to compare the biomechanical effect of a supplemental S1 long iliosacral screw versus a transsacral screw in an unstable type C vertically oriented sacral fracture model. MATERIALS AND METHODS: A type C pelvic ring injury was created in ten osteopenic/osteoporotic cadaver pelves by performing vertical osteotomies through zone 2 of the sacrum and the ipsilateral pubic rami. The sacrum was reduced maintaining a 2-mm fracture gap to simulate a closed-reduction model. All specimens were fixed using one 7.0-mm iliosacral screw into the S1 body. A supplemental long iliosacral screw was placed into the S1 body in five specimens. A supplemental transsacral S1 screw was placed in the other five. Each pelvis underwent 100,000 cycles at 250 N, followed by loading to failure. Vertical displacements at 25,000, 50,000, 75,000, and 100,000 cycles and failure force were recorded. RESULTS: Vertical displacement increased significantly (p < 0.05) within each group with each increase in the number of cycles. However, there was no statistically significant difference between groups in displacement or load to failure. CONCLUSIONS: Although intuitively a transsacral screw may seem to be better than a long iliosacral screw in conveying additional stability to an unstable sacral fracture fixation construct, we were not able to identify any biomechanical advantage of one method over the other.
Assuntos
Parafusos Ósseos , Fixação Interna de Fraturas/instrumentação , Fraturas Ósseas/cirurgia , Ílio/cirurgia , Ossos Pélvicos/lesões , Sacro/cirurgia , Fenômenos Biomecânicos , Cadáver , Fixação Interna de Fraturas/métodos , HumanosRESUMO
BACKGROUND: Acetabular fracture diagnosis is traditionally made with AP and oblique pelvic plain radiographs. Obesity may impair diagnostic accuracy of plain radiographs. New CT reconstruction algorithms allow for simulated radiographs that may eliminate the adverse imaging effects of obesity. QUESTIONS/PURPOSES: In obese patients with acetabular fractures, we compared CT-generated and plain radiographs in terms of (1) ability to classify fracture type, (2) agreement in fracture classification, and (3) surgeon performance at different experience levels. METHODS: CT-generated and plain radiograph image sets were created for 16 obese (BMI>35) patients with 17 acetabular fractures presenting from 2009 to 2011. Three orthopaedic trauma attending physicians, three senior residents, and three junior residents independently viewed these sets and recorded their diagnoses. These diagnoses were compared to the postoperative findings, which we defined as the gold standard for diagnosis. To assess intraobserver reliability, the same observers reviewed a rerandomized set 1 month later. We had 80% power to detect a 25% difference in the percentage of correctly classified fractures based on a post hoc sample size calculation and 80% power to detect a 0.10 difference in κ value based on both a priori and post hoc sample size calculations. RESULTS: With the numbers available (153 observations in each image set, 51 for each of the three observer groups), we found no differences between CT-generated and plain radiographs, respectively, in terms of percentage of correct diagnoses for the observer groups (all observers: 54% versus 49%, p=0.48; attendings: 61% versus 59%, p=0.83; senior residents: 51% versus 53%, p=0.84; and junior residents: 49% versus 35%, p=0.16). Furthermore, agreement between CT-generated and plain radiographic fracture classifications was substantial (κ=0.67). Nonetheless, the attending and senior resident groups performed better in correctly classifying the fracture than the junior residents when using plain radiographs (p=0.01 and p=0.049, respectively). Performance was not different when comparing the attendings to the senior resident and junior groups or comparing the senior residents to the junior residents using CT-generated radiographs (p=0.32, p=0.22, and p=0.83, respectively). CONCLUSIONS: CT-generated radiographs are as good as plain radiographs for experienced surgeons for classifying acetabular fractures in obese patients. CT-generated imaging may be valuable in both teaching and clinical settings, and it may spare the patient additional radiation exposure and discomfort. LEVEL OF EVIDENCE: Level II, diagnostic study. See the Instructions for Authors for a complete description of levels of evidence.
Assuntos
Acetábulo/diagnóstico por imagem , Acetábulo/lesões , Fraturas Ósseas/complicações , Fraturas Ósseas/diagnóstico por imagem , Obesidade/complicações , Intensificação de Imagem Radiográfica/métodos , Tomografia Computadorizada por Raios X/métodos , Acetábulo/cirurgia , Adulto , Idoso , Algoritmos , Feminino , Fraturas Ósseas/cirurgia , Humanos , Masculino , Pessoa de Meia-Idade , Variações Dependentes do Observador , Reprodutibilidade dos Testes , Estudos Retrospectivos , Adulto JovemRESUMO
BACKGROUND: In Germany a new reimbursement system for psychiatry and psychosomatics is under development. Based on total costs of each case from selected hospitals and day clinics, in 2013 the Institute for the Hospital Remuneration System (InEK) proposed to reimburse the hospital costs daily with step-wise decreasing remuneration, mainly depending on the ICD-10 diagnosis, duration of stay and some complicating factors (PEPP grouper). It is controversial whether this degressive system will result in an inadequate remuneration of patients with longer duration of severe symptoms, such as suicidality in depression or autoaggressive behavior in borderline personality disorder and will eventually lead to advantages for acutely ill patients with short duration of stay compared to chronically ill patients. OBJECTIVES: This study formulated and tested an alternative remuneration system (proof of concept) mainly based on an analysis of daily cost data instead of the total costs of each case. MATERIAL AND METHODS: The study is based on 147,749 treatment days from 4,633 cases of patients with psychotic disorders (PEPP-PA03) in 6 hospitals. As possible cost separating factors the study analyzed days with and without intensive psychiatric care, 1 to 1 care, psychological diagnostics, magnetic resonance imaging (MRI), acute crisis intervention, age at admission, the first days of treatment and day of discharge. RESULTS AND DISCUSSION: Nearly all factors tested were shown to be statistically significant in separating daily hospital costs. Based on these findings an alternative calculation algorithm (TEPPconcret), which grouped the cases with respect to age, intensive care, 1 to 1 care, treatment days 1-4 and day of discharge, was formulated and tested. For psychotic disorders TEPPconcret with a basic rate complemented by daily add-on payments depending on the effort involved, is a serious alternative to the PEPP system and awaits further evaluation.
Assuntos
Custos de Cuidados de Saúde/estatística & dados numéricos , Tempo de Internação/economia , Transtornos Mentais/economia , Transtornos Mentais/terapia , Psiquiatria/economia , Mecanismo de Reembolso/economia , Feminino , Alemanha/epidemiologia , Humanos , Masculino , Transtornos Mentais/diagnóstico , Pessoa de Meia-Idade , Projetos Piloto , Prevalência , Medicina Psicossomática/economiaRESUMO
BACKGROUND: Recent publications have shown an infection rate of 5-7 % for acetabular fractures treated with the Kocher-Langenbeck (K-L) approach. Using metallic staples to close hip skin incisions has been considered the gold standard. The purpose of this study was to answer the following: (1) will closure of a K-L incision after acetabular fracture surgery with a running subcuticular monocryl suture, then sealing the wound with 2-octyl cyanoacrylate (OCA), result in a lower infection rate compared to metallic staple closure? (2) Do incisions closed with subcuticular monocryl and OCA exhibit decreased drainage? (3) Is there a cost difference between these two methods? MATERIALS AND METHODS: In a prospective clinical study, 103 patients with acetabular fractures treated using the K-L approach were randomized into two groups: skin closure with metallic staples (n = 52) versus subcuticular running monocryl suture sealed with OCA (n = 51). RESULTS: Two postoperative deep infections (4 %) in the staples group required multiple debridements; no infections developed in the OCA group. However, there was no statistical difference between the groups, (p = 0.495). There was a statistically significant difference (p = 0.032) comparing days from surgery to a dry incision favoring OCA (4.2 versus 5.85 days). The patient charge was approximately $900 greater on average in the OCA group due to the increased time in the operating room required for the subcuticular closure. CONCLUSIONS: Closure with OCA and subcuticular monocryl showed no clinical disadvantages and appears to have a clinical advantage when compared to standard metallic staple skin closure in acetabular fracture surgery. However, additional patient costs may be incurred. LEVEL OF EVIDENCE: II.
Assuntos
Acetábulo/lesões , Fraturas Ósseas/cirurgia , Infecção da Ferida Cirúrgica/prevenção & controle , Suturas , Adesivos Teciduais , Técnicas de Fechamento de Ferimentos/instrumentação , Adulto , Cianoacrilatos , Dioxanos , Drenagem , Feminino , Preços Hospitalares , Humanos , Masculino , Duração da Cirurgia , Poliésteres , Estudos Prospectivos , Técnicas de Fechamento de Ferimentos/economiaRESUMO
CD271 has been applied to isolate mesenchymal stem cells (MSCs) from bone marrow and other tissues. Umbilical cord blood is a unique resource of stem cells and endothelial progenitor cells. Isolation of MSCs from umbilical cord blood, however, has been inefficient and inconsistent. This study was designed to examine the potential application of CD271 as a marker for the isolation of MSCs from umbilical cord blood. CD271+ cells were isolated from umbilical cord blood and bone marrow using CD271 antibody-conjugated microbeads, and characterized in osteogenic, chondrogenic and adipogenic differentiation. CD271+ cells from umbilical cord blood were slow to proliferate compared with those isolated from bone marrow. While CD271+ cells from bone marrow differentiated into osteogenic, chondrogenic and adipogenic lineages, there were no sound indications of differentiation by CD271+ cells from umbilical cord blood under the same differentiation conditions applied to the CD271+ cells from bone marrow. The study also found that bone marrow CD271+ cells remarkably upregulated the expression of chondrogenic genes under chondrogenic differentiation induction. When implanted into bone defects in mice, CD271+ cells from bone marrow regenerated significant bone, but the counterparts in umbilical cord blood formed little bone in the bone defects. In conclusion, CD271 is an efficient marker for MSC isolation from bone marrow but has failed to isolate MSCs from umbilical cord blood. CD271+ cells in bone marrow are particularly chondrogenic. The property of CD271+ cells is unique but varies from different tissues.
Assuntos
Células da Medula Óssea/citologia , Sangue Fetal/citologia , Células-Tronco Mesenquimais/citologia , Proteínas do Tecido Nervoso/metabolismo , Receptores de Fator de Crescimento Neural/metabolismo , Animais , Células da Medula Óssea/imunologia , Células da Medula Óssea/metabolismo , Diferenciação Celular/fisiologia , Separação Celular/métodos , Células Cultivadas , Sangue Fetal/imunologia , Sangue Fetal/metabolismo , Humanos , Masculino , CamundongosRESUMO
BACKGROUND: Implant failure after symphyseal disruption and plating reportedly occurs in 0% to 21% of patients but the actual occurrence may be much more frequent and the characteristics of this failure have not been well described. QUESTIONS/PURPOSES: We therefore determined the incidence and characterized radiographic implant failures in patients undergoing symphyseal plating after disruption of the pubic symphysis. METHODS: We retrospectively reviewed 165 adult patients with Orthopaedic Trauma Association (OTA) 61-B (Tile B) or OTA 61-C (Tile C) pelvic injuries treated with symphyseal plating at two regional Level I and one Level II trauma centers. Immediate postoperative and latest followup anteroposterior radiographs were reviewed for implant loosening or breakage and for recurrent diastasis of the pubic symphysis. The minimum followup was 6 months (average, 12.2 months; range, 6-65 months). RESULTS: Failure of fixation, including screw loosening or breakage of the symphyseal fixation, occurred in 95 of the 127 patients (75%), which resulted in widening of the pubic symphyseal space in 84 of those cases (88%) when compared with the immediate postoperative radiograph. The mean width of the pubic space measured 4.9 mm (range, 2-10 mm) on immediate postoperative radiographs; however, on the last radiographs, the mean was 8.4 mm (range, 3-21 mm), representing a 71% increase. In seven patients (6%), the symphysis widened 10 mm or more; however, only one of these patients required revision surgery. CONCLUSIONS: Failure of fixation with recurrent widening of the pubic space can be expected after plating of the pubic symphysis for traumatic diastasis. Although widening may represent a benign condition as motion is restored to the pubic symphysis, patients should be counseled regarding a high risk of radiographic failure but a small likelihood of revision surgery. LEVEL OF EVIDENCE: Level IV, case series. See Guidelines for Authors for a complete description of levels of evidence.
Assuntos
Mau Alinhamento Ósseo/cirurgia , Placas Ósseas , Fixação Interna de Fraturas/métodos , Complicações Pós-Operatórias/diagnóstico por imagem , Falha de Prótese , Diástase da Sínfise Pubiana/cirurgia , Adolescente , Adulto , Idoso , Mau Alinhamento Ósseo/diagnóstico por imagem , Análise de Falha de Equipamento , Feminino , Fixação Interna de Fraturas/efeitos adversos , Humanos , Escala de Gravidade do Ferimento , Masculino , Pessoa de Meia-Idade , Complicações Pós-Operatórias/epidemiologia , Diástase da Sínfise Pubiana/diagnóstico por imagem , Radiografia , Reoperação , Estudos Retrospectivos , Estados Unidos/epidemiologia , Adulto JovemRESUMO
OBJECTIVES: Performing an examination under general anesthesia (EUA) using dynamic stress fluoroscopy of patients with posterior wall acetabular fractures has been used as a tool to determine hip stability and the need for surgical intervention. The purpose of this study was to further evaluate the effectiveness of this technique, from a source other than its primary advocates, in patients with posterior wall acetabular fractures less than or equal to 50% who were stable on EUA and treated nonoperatively. DESIGN: Retrospective case series. SETTING: University Level 1 Trauma Center. PARTICIPANTS: Seventeen patients with a posterior wall acetabular fracture stable on EUA treated nonoperatively. INTERVENTION: The patients were treated nonoperatively as guided by an EUA negative for instability. Patient follow-up averaged 30 months (range, 6-64 months). MAIN OUTCOME MEASUREMENTS: Outcome evaluation included the modified Merle d'Aubigné clinical score and the Short Musculoskeletal Function Assessment Questionnaire. Radiographic evaluation for subluxation or arthritis consisted of the 3 standard pelvic radiographs. RESULTS: Radiographic evaluation showed all hips to be congruent with a normal joint space. Sixteen of the 17 patients had radiographic outcomes rated as "excellent"; 1 patient was rated "good." The modified Merle d'Aubigné score (obtained in 12 patients) averaged very good, with only 1 having less than a good (graded as fair) clinical outcome. The Short Musculoskeletal Function Assessment Questionnaire scores (from 11 patients) were not significantly different from normal and were within the normal reported values for all indices and categories. There was no correlation between fracture fragment size and outcome. CONCLUSIONS: This study further supports the contention that a stable hip joint, as determined by EUA, after posterior wall acetabular fracture treated nonoperatively is predictive of continued joint congruity, an excellent radiographic outcome, and good-to-excellent early clinical and functional outcomes. LEVEL OF EVIDENCE: Therapeutic Level IV. See Instructions for Authors for a complete description of levels of evidence.
Assuntos
Anestesia , Fraturas Ósseas , Fraturas do Quadril , Acetábulo/diagnóstico por imagem , Fixação Interna de Fraturas , Fraturas Ósseas/diagnóstico por imagem , Fraturas Ósseas/terapia , Humanos , Estudos Retrospectivos , Resultado do TratamentoRESUMO
Carbonic anhydrases (CAs), which catalyze the reversible reaction of carbonate hydration, are important for cartilage homeostasis. The full spectrum of CA activity of all 13 isoenzymes in articular cartilage is unknown. This study quantified the mRNA profile of CAs in rat articular cartilage, using quantitative polymerase chain reactions. Among the 13 functional CAs, CAs II, III, Vb, IX, XII and XIII were significantly expressed at mRNA level by the chondrocytes in articular cartilage. To verify these significantly expressed CAs in articular cartilage at protein level, immunohistochemistry was performed. While CAs III, Vb and XII distributed in the full-thickness of cartilage, including the calcified zone of cartilage, CA II was mainly localized in the proliferative zone of cartilage. CA IX was limited in the superficial zone of cartilage and CA XIII expressed in the superficial and partially mid zone. These results provide a framework for understanding individual CAs as well as the integrated CA family in cartilage biology, including matrix mineralization.
Assuntos
Anidrases Carbônicas/metabolismo , Cartilagem Articular/enzimologia , RNA Mensageiro/metabolismo , Animais , Cartilagem Articular/metabolismo , Condrócitos/metabolismo , Imuno-Histoquímica , Isoenzimas/metabolismo , Masculino , Ratos , Ratos WistarRESUMO
BACKGROUND: In a pilot study, two-dimensional (2-D) CT assessment of posterior wall fracture fragments predicted hip stability with small fracture fragments and instability for large fracture fragments. QUESTIONS/PURPOSES: To confirm the previous findings, we determined whether there is sufficient observer consistency and accuracy to predict hip stability in posterior wall acetabular fractures for this CT assessment method and assessed its ease of clinical use. METHODS: We selected 10 fractures having variable characteristics with known clinical outcome and created three study participant groups, based on level of training, for evaluation. Each observer reviewed the CT scans from the 10 fractures and applied the method in two separate sessions, the second after at least a 1-month washout period. RESULTS: Participants reported subjective ease in using the method, averaging 5 minutes (range, 3-11 minutes) for each assessment. Intraobserver and interobserver reliability were both greater than 0.80 regardless of the level of experience. Although sensitivity was 90%, specificity was only 61% after comparison with examination under anesthesia (EUA). Inappropriate nonoperative treatment would have occurred in 6% of cases and inappropriate operative treatment in 16%. CONCLUSIONS: This method for assessing hip instability is reliable, reproducible, and easy to learn and use. However, as a diagnostic tool in the clinical setting, it is useful only for fractures involving greater than 50% of the posterior wall owing to limited accuracy. For fractures less than 50%, EUA should be performed to determine hip stability.
Assuntos
Acetábulo/lesões , Fraturas Ósseas/diagnóstico por imagem , Luxação do Quadril/diagnóstico por imagem , Articulação do Quadril/diagnóstico por imagem , Instabilidade Articular/diagnóstico por imagem , Tomografia Computadorizada por Raios X/métodos , Acetábulo/diagnóstico por imagem , Acetábulo/fisiopatologia , Adolescente , Adulto , Fraturas Ósseas/complicações , Luxação do Quadril/etiologia , Luxação do Quadril/fisiopatologia , Humanos , Instabilidade Articular/etiologia , Instabilidade Articular/fisiopatologia , Masculino , Pessoa de Meia-Idade , Variações Dependentes do Observador , Valor Preditivo dos Testes , Reprodutibilidade dos Testes , Adulto JovemRESUMO
The bone morphogenetic protein (BMP) family of growth factors plays critical roles in bone formation. BMPs are regulated at multiple levels by various BMP antagonists. This study investigated how BMP antagonists are integrated into the cascade of events of bone formation during fracture healing. Forty mice underwent a controlled femur fracture; tissue samples at the fracture site were harvested at days 1, 3, 7, 14 and 21 after fracture, for quantification of the expression of BMPs and BMP antagonists. During fracture healing, BMP-2, -4 and -7 were up-regulated, but BMPR-1A and BMPR-2 showed reduced expression after day 14. Among BMP antagonists, the expressions of PRDC, SOST, Smad7, GREM1 and CERBERUS were generally down-regulated during fracture healing. In contrast, Noggin was significantly up-regulated in the first week after fracture; 7 days after fracture, other BMP antagonists, including DAN, CHRD, Smad6 and BAMBI, also showed significantly increased expression. In conclusion, this study indicates that BMP antagonists can be divided into two functional groups in relation to fracture healing: (1) those whose suppression may be essential for the initiation of osteogenesis; (2) those that are upregulated and may function in the remodeling of newly formed bone.
Assuntos
Proteínas Morfogenéticas Ósseas/antagonistas & inibidores , Consolidação da Fratura/fisiologia , Fraturas Ósseas/metabolismo , Animais , Proteínas Morfogenéticas Ósseas/metabolismo , Masculino , Camundongos , Camundongos Endogâmicos C57BL , Modelos Animais , Reação em Cadeia da Polimerase Via Transcriptase Reversa , Estatística como AssuntoRESUMO
The goals of treating an acetabular fracture are to restore the congruity and stability of the hip joint. Some fracture types may not require surgery for a satisfactory outcome, but a displaced fracture in the weight-bearing area of the acetabulum generally should be treated with open reduction and internal fixation. The surgery is complex and demanding, and the fracture reduction must be anatomic to obtain the best result. There is no doubt, however, that an experienced surgeon can achieve an excellent result. Usually a poor result is related to residual fracture displacement or a perioperative complication. The evaluation and treatment protocols initially developed by Letournel and Judet continue to be important; in addition, the surgeon should be aware of the progress made during the past decade.
Assuntos
Acetábulo/lesões , Fixação de Fratura , Fraturas Ósseas/diagnóstico , Fraturas Ósseas/cirurgia , Fraturas Ósseas/classificação , Lesões do Quadril/etiologia , Lesões do Quadril/patologia , Lesões do Quadril/cirurgia , Humanos , Fixadores Internos , Traumatismo Múltiplo/diagnóstico , Traumatismo Múltiplo/etiologia , Traumatismo Múltiplo/cirurgia , Osteotomia , Seleção de Pacientes , Recuperação de Função Fisiológica , Tomografia Computadorizada por Raios X , Resultado do TratamentoRESUMO
OBJECTIVE: The goal of this survey was to determine the current surgeon-preferred anterior surgical approach for the treatment of acetabular fractures in North America. DESIGN: Web-based survey; PARTICIPANTS:: Orthopaedic Trauma Association (OTA) members. METHODS: Active members of the OTA were solicited to participate in an OTA-sponsored survey asking for their preferred standard anterior surgical approach to the acetabulum, along with some general demographic data. The approach choices were: the classic ilioinguinal as described by Letournel, a modified ilioinguinal, the modified Stoppa (Anterior Intrapelvic) with or without a lateral window, the pararectus, and an alternative to be specified by the survey taker. RESULTS: Of the 675 total active OTA membership, 214 (32%) satisfactorily completed the survey. Of the 214 active members, only 32 (15%) prefer the classic ilioinguinal approach and 60 (28%) prefer some type of modified ilioinguinal approach. More than half of the active member respondents (121; 56.5%) prefer the modified Stoppa approach. Statistical analysis of the respondents' demographic data revealed only years in practice to be significantly different among treatment options (P < 0.01) with those with the least time in practice preferring the modified Stoppa. CONCLUSIONS: It seems that the modified Stoppa has become the preferred anterior acetabular fracture surgical approach in North America, being especially favored by those more recently in practice. The exact reasons for this change cannot be determined from this survey and are most likely multifactorial. However, training experience may play an important role.
Assuntos
Fraturas Ósseas , Ortopedia , Acetábulo/cirurgia , Fixação Interna de Fraturas , Fraturas Ósseas/cirurgia , Humanos , América do Norte/epidemiologia , Inquéritos e QuestionáriosRESUMO
PURPOSE: The purposes of this study were to determine the rate of venous thromboembolism (VTE) after discharge from the hospital in patients treated operatively with a pelvic ring or acetabular fracture and to define the main time frame in which VTE occurs within the 90-day period after hospital discharge. METHODS: California and Florida State Inpatient Databases from 2005 to 2009 were used to identify patients with clinically significant VTEs within 90 days of hospital discharge. ICD-9 diagnosis codes identified patients with a pelvic ring or acetabular fracture and a VTE. Procedure codes distinguished patients having surgical fracture treatment. Deep vein thrombosis (DVT) and pulmonary embolus (PE) were included. RESULTS: Overall, 13,589 patients had a pelvic ring or acetabular fracture and operative treatment. One hundred thirteen patients (0.83%) had a VTE within 90 days after hospital discharge: 69 (0.51%) had a DVT, 28 (0.21%) had a PE, and 16 (0.12%) had both. Twenty-four (28%) of DVTs and 10 (23%) of PEs occurred >35 days after discharge, being evenly distributed out to 90 days. There were five fatal PEs, occurring 2, 3, 7, 31, and 51 days after discharge. Therefore, overall, <0.2% of patients developed a DVT and <0.1% were diagnosed with a PE (only 1 fatal; <0.01%) >35 days after the index hospitalization. CONCLUSIONS: A substantial proportion of VTE events occur over 35 days after discharge; however, the overall risk is low with fatal PE being extremely low (<0.01%). Given the diminished VTE risk after 35 days, the decision to further extend antithrombotic drug therapy may be guided by patient-specific factors, such as prolonged immobility.
Assuntos
Fraturas Ósseas/cirurgia , Ossos Pélvicos/lesões , Complicações Pós-Operatórias/epidemiologia , Tromboembolia Venosa/epidemiologia , Adolescente , Adulto , Idoso , Idoso de 80 Anos ou mais , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Alta do Paciente , Embolia Pulmonar/epidemiologia , Fatores de Risco , Fatores de Tempo , Trombose Venosa/epidemiologia , Adulto JovemRESUMO
INTRODUCTION: In the open-book, rotationally unstable (OTA/AO type 61-B1.1) pelvic ring injury, the posterior sacroiliac complex is believed to remain intact. Therefore, anterior ring stabilization alone has been the standard treatment recommendation. However, treatment failures using this method have caused a reconsideration of this management strategy. Anterior plus posterior fixation is the main alternative. In the absence of any specific new guidelines, the choice of treatment currently relies on the preference of the treating surgeon. The objective of this survey was to determine the relative use of anterior plus posterior fixation, as opposed to the standard anterior fixation alone, for the treatment of open-book pelvic ring injuries. METHODS: An international group of 176 practicing trauma surgeons experienced in pelvic ring fracture fixation participated in an AO Foundation survey asking for their preferred standard surgical fixation (anterior alone or anterior plus posterior combined) for OTA/AO type 61-B1.1 open-book pelvic fractures. RESULTS: Anterior plate fixation alone (group 1) was preferred by 56% of the survey participants, and combined anterior plus posterior fixation (group 2) was preferred by 44%. Statistical analysis revealed that group 1 participants were significantly older than group 2 participants (P = 0.03) and had more years of surgical experience (P = 0.02). CONCLUSIONS: Concern regarding the inadequacy of anterior fixation alone has led many surgeons, especially those more recently in practice, to add posterior fixation, despite limited data to determine its indications. No doubt the OTA/AO type B 1.1 pelvic ring disruption actually represents a wide spectrum of injury. Further study is needed to determine the best fixation method.