Your browser doesn't support javascript.
loading
Mostrar: 20 | 50 | 100
Resultados 1 - 20 de 83
Filtrar
Mais filtros

Base de dados
Tipo de documento
Intervalo de ano de publicação
1.
J Clin Invest ; 71(5): 1114-23, 1983 May.
Artigo em Inglês | MEDLINE | ID: mdl-6189857

RESUMO

This paper is a cross-sectional study of spontaneous benign prostatic hyperplasia (BPH) in a single canine species. The effects of aging and hormonal changes on the growth, histology, and glandular secretory function of the canine prostate were studied in 42 male beagles ranging in age from 8 mo to 9 yr. The beagle prostate enlarges for at least 6 yr, whether normal or hyperplastic. In contrast, prostatic secretory function, determined by ejaculate volume and total ejaculate protein, declines markedly after 4 yr of age. These reciprocal growth and functional changes in the prostate are closely associated with a progressive increase in the incidence of BPH, which is already apparent in some dogs by age two. With age there is a modest decrease in serum androgen levels with no apparent change in serum 17 beta-estradiol levels. This suggests that the growth and functional changes that are associated with the development of BPH and are initiated very early in life reflect an altered sensitivity of the prostate to serum androgens or a response to the relative decrease in the serum androgen to estrogen ratio.


Assuntos
Androgênios/sangue , Doenças do Cão/fisiopatologia , Estradiol/sangue , Próstata/fisiopatologia , Hiperplasia Prostática/veterinária , Envelhecimento , Animais , Modelos Animais de Doenças , Cães , Masculino , Tamanho do Órgão , Próstata/patologia , Hiperplasia Prostática/patologia , Hiperplasia Prostática/fisiopatologia , Contagem de Espermatozoides
2.
Cancer Res ; 50(20): 6668-74, 1990 Oct 15.
Artigo em Inglês | MEDLINE | ID: mdl-2208131

RESUMO

Cohorts of 4- to 5-wk-old female Fischer 344 rats received four biweekly 1.5-mg doses of N-methyl-N-nitrosourea (MNU) intravesically and were sacrificed at various intervals. By 13 wk after initiation of the carcinogen, all animals have flat epithelial atypia and/or papillary transitional cell bladder carcinomas, and 67% of the lesions are histological Grade II or III. By 20 wk, 83% have gross bladder wall muscle-invasive tumors that eventually kill the host. There was no gross evidence of visceral metastases in any animal. This rat model of transitional cell carcinoma of the bladder is useful because: (a) all animals develop progressive neoplastic changes in situ within 4 mo after initiation of MNU treatment; (b) these lesions progress to grossly detectable bladder tumors which invade the bladder wall and kill the host; (c) this full progression of bladder epithelial cells from atypical hyperplasia through flat carcinoma in situ to transitional cell carcinoma occurs at discrete time points; (d) the histology of the grossly detectable tumors is that of invasive transitional cell carcinomas; and (e) no leukemias, breast cancers, lymphomas, or other non-bladder tumors are induced. Six MNU-induced bladder wall-invasive tumors were karyotyped, and all tumors were diploid with 42 chromosomes. Three of the tumors had apparently normal karyotypes, while three tumors had karyotypes containing one or more cytogenetic structural markers. One of these markers (i.e., 8p+) was observed in two of the three tumors. The level of expression of total ras p21 (N-, Ki-, and Ha-ras p21) and codon 12-mutated c-Ha-ras p21 (i.e., glycine to glutamic acid mutation in codon 12) in a series of these MNU-induced bladder tumors was determined by Western blot analysis. No increase in the total ras p21 nor any expression of codon 12-mutated c-Ha-ras p21 was detected in any of these tumors.


Assuntos
Carcinoma de Células de Transição/patologia , Neoplasias da Bexiga Urinária/patologia , Animais , Carcinoma de Células de Transição/induzido quimicamente , Carcinoma de Células de Transição/genética , Transformação Celular Neoplásica , Aberrações Cromossômicas , Modelos Animais de Doenças , FANFT , Feminino , Metilnitrosoureia , Proteínas Proto-Oncogênicas p21(ras)/análise , Ratos , Ratos Endogâmicos F344 , Neoplasias da Bexiga Urinária/induzido quimicamente , Neoplasias da Bexiga Urinária/genética
3.
J Clin Endocrinol Metab ; 56(1): 139-46, 1983 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-6183287

RESUMO

It has been well established that hyperplastic human prostatic tissue is characterized by a 3- to 4-fold elevation in the content of dihydrotestosterone (DHT) compared to that in normal prostatic tissue. However, the exact mechanism responsible for DHT accumulation has not been established. One hypothesis for the abnormal elevation of DHT content in hyperplastic prostatic tissue is that changes occur in the tissue itself which shift the overall balance of androgen metabolism favoring the increased accumulation of DHT. To test this hypothesis, the metabolic activities that produce and remove DHT were determined in a series of normal as well hyperplastic human prostates. The results of these studies demonstrated that in each of the eight separate hyperplastic prostatic tissues assayed, there was a significant increase in 5 alpha-reductase activity producing DHT concomitant with significant decreases in the 3 alpha- and 3 beta-hydroxysteroid oxidoreductase reductase and 17 beta-hydroxysteroid oxidoreductase oxidase activities removing DHT. These specific alterations result in a major shift in the overall balance of androgen metabolism which favors an increase in the net formation of DHT in hyperplastic prostatic tissue. Such a shift in androgen metabolism is, therefore, at least one mechanism for the well documented increase in DHT content found in hyperplastic human prostatic tissue.


Assuntos
Di-Hidrotestosterona/metabolismo , Hiperplasia Prostática/metabolismo , 17-Hidroxiesteroide Desidrogenases/metabolismo , 3-Hidroxiesteroide Desidrogenases/metabolismo , 3-Oxo-5-alfa-Esteroide 4-Desidrogenase/metabolismo , 3-alfa-Hidroxiesteroide Desidrogenase (B-Específica) , Adulto , Idoso , Androstano-3,17-diol/metabolismo , Etiocolanolona/análogos & derivados , Etiocolanolona/metabolismo , Humanos , Masculino , Pessoa de Meia-Idade , Próstata/metabolismo , Testosterona/metabolismo
4.
Urology ; 46(3 Suppl A): 71-6, 1995 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-7544517

RESUMO

This article reviews the clinical and pathologic characteristics of nonpalpable (Stage T1c) prostate cancer reported in five studies published to date. Stage T1c tumors more closely resemble palpable prostate cancers (Stage T2) than they do incidental prostate cancers detected in cystoprostatectomy specimens. The mean tumor volume of Stage T1c tumors is about 50 times greater (2.0 mL vs 0.04 mL) than incidental cystoprostate cancers. Only about 20-25% of T1c tumors have a tumor volume < 0.5 mL; tumors > 0.5 mL are considered to have significant biologic potential. Futhermore, 30-50% of T1c tumors have penetrated the prostatic capsule, 20-30% demonstrate positive surgical margins, and 5-10% demonstrate seminal vesicle invasion and/or positive pelvic lymph nodes. Possible reasons for nonpalpability of T1c tumors include tumor location in the central and/or anterior zones of the prostate and increased gland volume due to benign prostatic hyperplasia, making T1c tumors more difficult to palpate. A combination of serum prostate-specific antigen (PSA) density < 0.1 and favorable needle biopsy pathology (no Gleason 4 or 5 pattern in any core, < 3 cores positive for cancer, and < 50% involvement of any single core) will identify about 75% of men with tumors < 0.5 mL who might be followed without immediate treatment. Overall, however, these data indicate that most T1c tumors are significant cancers > 0.5 mL that warrant aggressive treatment in accordance with age and other health considerations.


Assuntos
Neoplasias da Próstata/patologia , Biópsia , Humanos , Masculino , Estadiamento de Neoplasias , Palpação , Antígeno Prostático Específico/sangue , Neoplasias da Próstata/diagnóstico
5.
Urology ; 34(2): 69-72, 1989 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-2474882

RESUMO

A common affliction of older men is bladder outlet obstruction secondary to benign prostatic hyperplasia for which the standard treatment is surgical prostatectomy. We report on six men with urinary retention from benign prostatic hyperplasia who were not medically able to undergo surgical prostatectomy but were successfully treated with the luteinizing hormone-releasing hormone (LH-RH) agonist, leuprolide acetate. This therapy is exemplified by the case of a sixty-six-year-old man with hemophilia B and urinary retention. The patient was treated with daily subcutaneous injections of 1 mg of leuprolide acetate, and prostatic size decreased from 132 g to 42 g, with initiation of spontaneous micturition while on treatment. For patients with symptomatic benign prostatic hyperplasia who are not candidates for surgery, treatment with an LH-RH agonist, such as leuprolide acetate, should be considered as a possible alternative.


Assuntos
Hormônio Liberador de Gonadotropina/análogos & derivados , Hiperplasia Prostática/complicações , Transtornos Urinários/tratamento farmacológico , Idoso , Idoso de 80 Anos ou mais , Avaliação de Medicamentos , Hormônio Liberador de Gonadotropina/uso terapêutico , Hemofilia B/complicações , Humanos , Leuprolida , Masculino , Pessoa de Meia-Idade , Tamanho do Órgão/efeitos dos fármacos , Próstata/efeitos dos fármacos , Próstata/patologia , Hiperplasia Prostática/diagnóstico , Ultrassonografia
6.
Urology ; 44(2): 232-6, 1994 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-8048199

RESUMO

OBJECTIVES: To compare the effect of epidural and general anesthesia on the postoperative course and complication rate in patients undergoing radical prostatectomy. METHODS: Ninety-eight men scheduled for radical retropubic prostatectomy (RRP) were randomly assigned to receive epidural anesthesia only (EA, n = 34), combined epidural and general anesthesia (EG, n = 33) or general anesthesia only (GA, n = 31). In the EA group, epidural anesthesia was induced and maintained with bupivacaine. In the EG group, patients received epidural bupivacaine after the induction of general anesthesia. In the GA group, anesthesia was induced with morphine and maintained with isoflurane. In the postoperative period, epidural patient-controlled analgesia (PCA) was maintained in all patients for 3 to 5 days. Patients were evaluated throughout the hospitalization period and at 3, 6, and 12 weeks following surgery. RESULTS: The three groups did not differ with regard to postoperative pain, bleeding, urine output, fever, length of paralytic ileus, or length of hospitalization. No major cardiovascular, pulmonary, or neurologic complications occurred in any of the patients either perioperatively or in the first 3 months postoperatively. CONCLUSIONS: Intraoperative anesthetic technique was not associated with a different postoperative complication rate in patients undergoing RRP. The very low incidence of complications and the uniform postoperative analgesic regimen may have contributed to the similarity between groups.


Assuntos
Anestesia Epidural/efeitos adversos , Anestesia Geral/efeitos adversos , Complicações Pós-Operatórias/epidemiologia , Prostatectomia , Analgesia Controlada pelo Paciente , Seguimentos , Humanos , Tempo de Internação , Masculino , Pessoa de Meia-Idade , Dor Pós-Operatória/tratamento farmacológico , Complicações Pós-Operatórias/etiologia
7.
Urology ; 45(6): 993-9, 1995 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-7771032

RESUMO

OBJECTIVES: There are conflicting reports on the influence of different anesthetic techniques, such as regional versus general anesthesia, on intraoperative blood loss. The purpose of this study was to elucidate the effects of anesthetic technique on intraoperative blood loss in men undergoing radical retropubic prostatectomy (RRP). METHODS: One hundred patients undergoing RRP for prostate cancer were randomly assigned to receive either epidural anesthesia (EA), combined epidural and general anesthesia (EG), or general anesthesia alone (GA). Intraoperative blood loss was calculated by using a formula that accounted for the volume and hematocrit of the fluid suctioned from the surgical field, blood absorbed on surgical pads, and the patient's hematocrit. RESULTS: Mean blood loss in the EA group (1490 +/- 90 mL; mean +/- SEM) was significantly less than mean blood loss in both the EG group (1810 +/- 100 mL) and the GA group (1940 +/- 130 mL) (P = 0.01). Blood loss was not different between the EG and the GA groups (P = 0.7). Significantly less blood was transfused during surgery in the EA group (730 +/- 50 mL) compared with the EG (960 +/- 60 mL) and GA (950 +/- 70 mL) groups (P = 0.02). CONCLUSIONS: Similar blood loss in patients receiving general anesthesia, either alone or when combined with epidural anesthesia, implies that epidural anesthesia did not reduce bleeding, but, rather, that general anesthesia increased blood loss.


Assuntos
Anestesia Epidural , Anestesia Geral , Perda Sanguínea Cirúrgica/estatística & dados numéricos , Prostatectomia , Pressão Sanguínea , Humanos , Período Intraoperatório , Masculino , Pessoa de Meia-Idade , Análise Multivariada , Prostatectomia/métodos
8.
Urology ; 56(1): 149, 2000 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-10869646

RESUMO

We describe a new technique to secure a urethral catheter using a horizontal drain tube stabilizer. This device is reliable, inexpensive, and more comfortable for patients than either adhesive tape or leg straps.


Assuntos
Cateterismo Urinário/métodos , Humanos , Masculino , Cateterismo Urinário/instrumentação
9.
Urology ; 45(4): 657-63, 1995 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-7716848

RESUMO

OBJECTIVES: To evaluate and characterize erectile manifestations associated with sickle cell disease using nocturnal penile tumescence testing with polysomnography (NPT/PSG) and magnetic resonance imaging (MRI) of the penis. METHODS: Six variably potent men with sickle cell disease, of whom 5 reported a history of priapism, underwent comprehensive evaluations of erectile function. Evaluations involved a medical history and physical examination with completion of priapism and sexual function questionnaires, followed by NPT/PSG and MRI of the penis. RESULTS: Many different erectile abnormalities were identified in this group using NPT/PSG, although nocturnal erection durations as well as detumescence times were uniformly prolonged. Various axial rigidity measurements were obtained, which correlated fairly well with individual reports of erectile function. MRI findings ranged from normal corporeal anatomy to corporeal destruction with intracorporeal fibrosis and hemosiderin deposition. CONCLUSIONS: In sickle cell disease, the erectile dysfunction that commonly occurs may be markedly different among men with this disease and may not always be predicted on the basis of clinical history of priapism. Generally, clinical assessments of erectile function may be derived from clinical histories and physical examinations. NPT/PSG and MRI of the penis are in accord with these assessments, obviating their routine use, although they may be valuable management adjuncts in certain situations.


Assuntos
Anemia Falciforme/complicações , Ereção Peniana/fisiologia , Priapismo/etiologia , Adolescente , Adulto , Anemia Falciforme/fisiopatologia , Humanos , Imageamento por Ressonância Magnética , Masculino , Pênis/patologia , Pênis/fisiopatologia , Polissonografia , Priapismo/diagnóstico
10.
Urology ; 45(5): 831-8, 1995 May.
Artigo em Inglês | MEDLINE | ID: mdl-7538245

RESUMO

OBJECTIVES: Following surgery, men with recurrent prostate cancer have an isolated elevation in serum prostate-specific antigen (PSA) well in advance of measurable metastatic disease. Rational patient selection for new forms of adjuvant therapy, for example, gene therapy, is imperative. METHODS: In a retrospective study of two cohorts, we used proportional hazards regression analysis to develop and validate a multifactor model for identifying men who are at high risk of cancer recurrence. The model cohort consisted of 216 men with clinical Stage T2b and T2c treated by 1 urologist. The validation cohort consisted of 214 men with Stage T2b and T2c disease. RESULTS: A model for log relative risk, Rw, used serum PSA with a sigmoidal transformation (PSAST), radical prostatectomy Gleason score (GS), and pathologic stage (PS) as specimen confined or nonspecimen confined: Rw = (PSAST x 0.06) + (GS x 0.54) + (PS x 1.87). Recurrence risk categories were determined as low risk if Rw is less than 4.0, intermediate risk if it is 4.0 to less than 5.75, and high risk if Rw is more than 5.75. The observed Kaplan-Meier actuarial analysis of the three risk groups correlated well with the predictions determined for the model cohort. We then validated this model independently using a second cohort of 214 men with similar age, stage, and grade treated by 3 different urologists at two different institutions. CONCLUSIONS: The recurrence rates for men in the high-risk group are similar to those for men with positive lymph nodes and justifies exploration of experimental adjuvant therapy within this group using this model of patient selection.


Assuntos
Recidiva Local de Neoplasia/epidemiologia , Seleção de Pacientes , Neoplasias da Próstata/epidemiologia , Análise Atuarial , Adulto , Idoso , Estudos de Coortes , Terapia Combinada , Seguimentos , Humanos , Masculino , Pessoa de Meia-Idade , Recidiva Local de Neoplasia/patologia , Recidiva Local de Neoplasia/terapia , Estadiamento de Neoplasias , Valor Preditivo dos Testes , Modelos de Riscos Proporcionais , Antígeno Prostático Específico/sangue , Prostatectomia , Neoplasias da Próstata/sangue , Neoplasias da Próstata/patologia , Neoplasias da Próstata/cirurgia , Neoplasias da Próstata/terapia , Reprodutibilidade dos Testes , Estudos Retrospectivos , Fatores de Risco
11.
Hematol Oncol Clin North Am ; 6(1): 31-9, 1992 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-1556051

RESUMO

Recent studies have provided the first clues as to the molecular mechanisms responsible for bladder carcinogenesis. Cytogenetic and molecular studies have demonstrated nonrandom changes of chromosomes 1, 5, 7, 9, 11, and 17. The finding of monosomy of chromosome 9 in early noninvasive lesions has initiated a search for a bladder-specific gene responsible for bladder oncogenesis. Activation of ras and erbB oncogenes has been reported, although the role that these changes play in bladder cancer is not yet understood. Inactivation of two well-characterized tumor suppressor genes, p53 and Rb, also appears to be important in the pathogenesis of bladder cancer, and evidence suggests that inactivation of p53 correlates with the acquisition by bladder cancer cells of the invasive phenotype. Although the picture is far from complete, it is clear that for the first time an understanding of the molecular events responsible for bladder cancer is possible, and that this information will have clinical impact on patients in the near future.


Assuntos
Neoplasias da Bexiga Urinária/genética , Regulação Neoplásica da Expressão Gênica , Genes Supressores de Tumor/fisiologia , Humanos , Oncogenes/fisiologia
12.
Urol Clin North Am ; 28(3): 535-43, 2001 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-11590812

RESUMO

Nerve-sparing radical prostatectomy can be performed safely in most men undergoing radical prostatectomy. As is true in many aspects of prostate cancer diagnosis and therapy, the key element is patient selection. With many prostate tumors diagnosed at an earlier stage, the authors have seen a shift toward more favorable pathologic findings at the time of surgery. Concomitant with the success of early detection of prostate cancer is the realization that men are younger at the time of diagnosis and more interested in preserving sexual function. This article has described factors associated with an increased risk for extraprostatic tumor and, subsequently, an increased possibility of postprostatectomy cancer recurrence. Except for the previously mentioned absolute contraindications, none of these factors, by themselves, should be used to exclude a patient from nerve-sparing prostatectomy. Instead, meticulous attention must be given to the surgical dissection. If any doubt remains regarding residual tumor, the surgeon should err on the side of caution and remove the neurovascular bundle. The use of standardized intraoperative frozen-section analysis can help guide these decisions. The patient must be informed before surgery regarding the risks of nerve-sparing surgery, the potency rates of the surgeon, and the possibility that, to ensure adequate cancer control, the nerves may be sacrificed despite any preoperative optimism favoring the potential for their salvage.


Assuntos
Prostatectomia/métodos , Neoplasias da Próstata/cirurgia , Contraindicações , Humanos , Cuidados Intraoperatórios , Masculino , Recidiva Local de Neoplasia/epidemiologia , Próstata/inervação , Próstata/cirurgia , Neoplasias da Próstata/patologia , Fatores de Risco
13.
Urol Clin North Am ; 18(4): 659-76, 1991 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-1949399

RESUMO

Radical cystoprostatectomy is considered one of the most difficult urologic operations. The nerve-sparing modifications that have allowed preservation of potency have resulted from an improved understanding of pelvic anatomy. This knowledge is not only important for preservation of potency; it also allows the entire operation to be done more precisely with increased exposure and decreased perioperative morbidity. Although many of the steps described above may seem routine to the urologist who does this operation frequently, we hope that this step-by-step guide proves useful to the practicing urologist who does only a few each year and to the resident who is learning the procedure.


Assuntos
Cistectomia/métodos , Prostatectomia/métodos , Humanos , Cuidados Intraoperatórios/métodos , Ligamentos/cirurgia , Excisão de Linfonodo , Masculino , Pelve , Cuidados Pós-Operatórios , Cuidados Pré-Operatórios , Decúbito Dorsal , Ureter/cirurgia
17.
J Urol ; 140(3): 518-22, 1988 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-3411665

RESUMO

Although response to intracorporeal pharmacological erection testing has been proposed to determine the etiology of impotence, physiological criteria predicting this response have not been established and the literature includes conflicting results regarding which patients respond to pharmacological erection therapy. In this study 37 impotent patients underwent a diagnostic nocturnal penile tumescence evaluation (including measurements of rigidity, pulsations and bulboischiocavernosus muscle activity) and the results were correlated with subsequent response to intracorporeal pharmacological testing. Most but not all patients with psychogenic impotence and all with neurogenic impotence responded with good erections. For vasculogenic impotence response rate depended upon impairment severity determined from nocturnal penile tumescence measurements; none of the severe cases versus 90 per cent of the milder cases responded. The results indicate that response to intracorporeal pharmacological testing does not accurately distinguish psychogenic from organic impotence, is best for neurogenic impotence and worst for severe vasculogenic impotence, and can be predicted accurately by nocturnal penile tumescence measurements.


Assuntos
Disfunção Erétil/diagnóstico , Papaverina/farmacologia , Ereção Peniana , Fentolamina/farmacologia , Adulto , Idoso , Disfunção Erétil/etiologia , Humanos , Masculino , Pessoa de Meia-Idade , Ereção Peniana/efeitos dos fármacos
18.
J Urol ; 139(6): 1260-3, 1988 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-3131545

RESUMO

We report on a 63-year-old man with persistent urinary retention owing to a large bladder diverticulum. To our knowledge this is the second case reported in the literature. A simple technique for excision of large vesical diverticula is described.


Assuntos
Divertículo/complicações , Doenças da Bexiga Urinária/complicações , Transtornos Urinários/etiologia , Divertículo/cirurgia , Humanos , Masculino , Métodos , Pessoa de Meia-Idade , Bexiga Urinária/cirurgia , Doenças da Bexiga Urinária/cirurgia
19.
J Urol ; 143(1): 51-4, 1990 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-2294261

RESUMO

A total of 50 consecutive male patients underwent simultaneous Snap-Gauge and full nocturnal penile tumescence evaluation with objective rigidity measurements to determine the correlation between the 2 studies. Subsequent clinical evaluation was conducted in patients in whom the 2 tests differed regarding diagnoses to determine which test more accurately predicted the clinical outcome. One patient was excluded from the study for technical reasons. Of 14 patients who had a normal Snap-Gauge evaluation, defined by breakage of all 3 bands, 12 (86%) had a normal and 2 (14%) had an abnormal nocturnal penile tumescence evaluation. A total of 28 patients failed to break any of the Snap-Gauge bands and 7 broke only 1 or 2 bands. Of these 35 patients with an abnormal Snap-Gauge study 14 (40%) had a normal and 21 (60%) had an abnormal nocturnal penile tumescence evaluation. In a subsequent clinical evaluation 1 of the 2 patients with a normal Snap-Gauge study and an abnormal nocturnal penile tumescence test reported continued inadequate sexual function and, subsequently, he received a penile prosthesis. Of the 14 patients with an abnormal Snap-Gauge study and a normal nocturnal penile tumescence test 11 were located and 8 were sexually active with adequate erections for intercourse without further medical treatment other than counseling. We conclude that the correlation between Snap-Gauge and nocturnal penile tumescence is not good, and that the nocturnal penile tumescence test is more accurate to determine the clinical diagnosis.


Assuntos
Disfunção Erétil/fisiopatologia , Ereção Peniana , Adulto , Idoso , Humanos , Masculino , Pessoa de Meia-Idade , Sono/fisiologia , Urologia/instrumentação
20.
CA Cancer J Clin ; 42(4): 212-22, 1992.
Artigo em Inglês | MEDLINE | ID: mdl-1623431

RESUMO

Recent advances in our understanding of the surgical anatomy of the prostate have led to an improved operative technique for radical prostatectomy. This technique achieves excellent results in terms of urinary continence and preservation of sexual function without compromising cancer control. It is therefore reasonable to offer radical prostatectomy for the cure of localized prostate cancer to patients who are otherwise well and have a life expectancy of more than 10 years.


Assuntos
Prostatectomia , Neoplasias da Próstata/cirurgia , Adulto , Idoso , Disfunção Erétil/etiologia , Seguimentos , Humanos , Masculino , Pessoa de Meia-Idade , Metástase Neoplásica , Recidiva Local de Neoplasia , Prostatectomia/efeitos adversos , Prostatectomia/métodos , Neoplasias da Próstata/patologia , Incontinência Urinária/etiologia
SELEÇÃO DE REFERÊNCIAS
DETALHE DA PESQUISA