[Antibiotic therapy of Salmonella infection in infants during the first year of life and methods if its correction]. / Antibiotikoterapiia sal'monelleza u detei pervogo goda zhizni i metody ee korrektsii.

The efficacy of antibiotic therapy of salmonellosis was studied and functional activity of peripheral blood leukocytes from electron microscopic data was estimated in 200 infants. It was shown that the use of antibiotics in combination with immunostimulants such as leukocyte mass, lysozyme and prodigiozan in complex therapy of salmonellosis in infants had a favourable effect on both the time course of the clinical signs and the functional state of the neutrophil leukocytes. The duration of the treatment decreased by 6.14 +/- 0.34 days and repeated isolation of the pathogen from the host appeared to be less frequent.

[Antibiotic therapy of intestinal infections complicated by toxicosis and exicosis in children with immunodeficiency syndromes]. / Antibiotikoterapiia pri kishechnykh infektsiiakh, oslozhnennykh toksikozom i éksikozom u detei s immunodefitsitnym sostoianiem.

Clinical processes of acute intestinal infections complicated by toxicosis and exicosis and some host immunological parameters were studied in infants with secondary immunodeficiency. A special treatment scheme was developed including combined use of antibiotics, human immune globulin administered intravenously and cytochrome C. The scheme provided a decrease in the treatment duration by 8.6 +/- 1.1 days. Advanced and chronic diseases and fatal outcomes were absent. It was concluded that the developed scheme increased host immunological reactivity and efficacy of antibiotic therapy. It was recommended for wide clinical use in pediatric clinical care.

[Increased effectiveness of antibiotic therapy with adaptogens in dysentery and Proteus infection in children]. / Povyshenie éffektivnosti antibiotikoterapii pri dizenterii i proteinoi infektsii adaptogenami u detei.

The course of the disease and the host immunological reactivity (IgA, IgM, IgG, CPhI, IgG and IgM antibody titers in the HIT, blood bactericidic properties) were studied in 258 children aged 0 to 14 year suffering from acute dysentery caused by Shigella sonnei and flexneri and enterocolitis of the Proteus etiology. 157 patients were treated with monomycin and kanamycin in combination with adaptogens, such as Eleuterococcus and Echinopanax elatum Nakai L. and 101 patients were treated with the antibiotics alone. It was shown that the use of the adaptogens decreased the periods of the diseases. It is concluded that adaptogens increase the efficacy of antibiotic therapy in children with dysentery and Proteus infection.

[The characteristics of the course of suppurative meningitis in children]. / Osobennosti techeniia gnoinykh meningitov u detei.

The clinical course of meningitides of different etiology was studied in 135 children. In meningitis of non-meningococcal etiology there is a prevalence of forms with brain involvement (meningoencephalitis) that are characterized by a prolonged intoxication, protracted course and residual sequels. The clinical diagnosis is difficult and requires bacteriological and serological examinations.

[Use of tablet forms of monomycin in children with acute dysentery]. / Ispol'zovanie tabletirovannykh form monomitsina pri ostroi dizenterii u detei.

The clinical picture of acute dysentery caused mainly by Shigella sonnei was studied in 160 children: 50 children were treated with monomycin tablets and for the treatment of 110 children monomycin in the form of amorphous powder in bottles was used. The treatment was carried out in accordance with the official instructions. Coincidence of the recovery time in the both groups was registered. When the patients were treated with monomycin tablets, 5 and 15-34 per cent of the antibiotic a daily dose was excreted with the urine and excrements respectively. It was concluded that monomycin in the from of tablets was more convenient in the treatment of children.

[Effectiveness of tobramycin in young children with Salmonella infection]. / Effektivnost' tobramitsina pri sal'monelleznoi infektsii u detei rannego vozrasta.

The intestinal form of salmonellosis caused by S. typhimurium and the host immunity were studied in 108 infants. 60 infants were treated with ampicillin and the other 48 infants with tobramycin. The recovery period in patients treated with tobramycin was 8 days less as compared to the patients treated with ampicillin After discontinuation of the tobramycin use the pathogen was not detected in the repeated platings. Bactericidal function of neutrophils in these patients returned to normal within 15 days after the beginning of the treatment. Tobramycin was shown to be a highly active antibiotic in the treatment of salmonellosis of infants. No side effects were observed.