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1.
Ecotoxicol Environ Saf ; 154: 237-244, 2018 Jun 15.
Artigo em Inglês | MEDLINE | ID: mdl-29476973

RESUMO

The use of engineered nanomaterials (ENMs) for environmental remediation, known as nanoremediation, represents a challenging and innovative solution, ensuring a quick and efficient removal of pollutants from contaminated sites. Although the growing interest in nanotechnological solutions for pollution remediation, with significant economic investment worldwide, environmental and human risk assessment associated with the use of ENMs is still a matter of debate and nanoremediation is seen yet as an emerging technology. Innovative nanotechnologies applied to water and soil remediation suffer for a proper environmental impact scenario which is limiting the development of specific regulatory measures and the exploitation at European level. The present paper summarizes the findings from the workshop: "Ecofriendly Nanotechnology: state of the art, future perspectives and ecotoxicological evaluation of nanoremediation applied to contaminated sediments and soils" convened during the Biannual ECOtoxicology Meeting 2016 (BECOME) held in Livorno (Italy). Several topics have been discussed and, starting from current state of the art of nanoremediation, which represents a breakthrough in pollution control, the following recommendations have been proposed: (i) ecosafety has to be a priority feature of ENMs intended for nanoremediation; ii) predictive safety assessment of ENMs for environmental remediation is mandatory; (iii) greener, sustainable and innovative nano-structured materials should be further supported; (iii) those ENMs that meet the highest standards of environmental safety will support industrial competitiveness, innovation and sustainability. The workshop aims to favour environmental safety and industrial competitiveness by providing tools and modus operandi for the valorization of public and private investments.


Assuntos
Recuperação e Remediação Ambiental , Nanoestruturas , Nanotecnologia , Consenso , Ecotoxicologia , Poluição Ambiental , Poluentes do Solo , Poluição da Água
2.
Ecotoxicology ; 25(5): 1033-9, 2016 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-27106013

RESUMO

The calanoid copepod Acartia tonsa has been recommended as a marine organism for ecotoxicological tests due to its wide distribution, short life cycle and high productivity. This species is used in acute and chronic toxicity tests to assess water and sediment quality; egg hatching success and the survival of the first larval stages are considered endpoints. Toxicity test protocols require a large number of organisms and an appropriate culture system. Eggs stored under conditions that delay hatching could ensure sufficient quantities of biological materials for ecotoxicological tests. In the current study early-spawned eggs were stored at 3 °C (±1) up to 240 days and their hatching success was evaluated on a monthly basis. Our results showed that the percentage of hatching success for eggs stored for 30 days was >80 % and decreased by about 8 % for every 20 days of storage, up to 120 days. A further increase of time in cold storage brought about a significant reduction, in statistical term, of hatching success compared with the control group (43.69 ± 22.19 %). Almost 50 % of eggs hatched or died during the cold storage period, with more than 80 % lost after periods longer than 150 days. To verify the suitability of stored eggs for toxicity test, 48 h acute tests were performed using nickel chloride as a referent toxicant. Eggs stored for 30, 60, 90 and 120 days gave EC50 values ranging from 0.130 to 0.221 mg L(-1), similar to the value recorded for early-spawned eggs, suggesting that these eggs can be used for ecotoxicological tests. Our results open new possibilities for a wider use of the Mediterranean strain of A. tonsa copepod for ecotoxicological tests.


Assuntos
Copépodes/fisiologia , Monitoramento Ambiental/métodos , Testes de Toxicidade Aguda/métodos , Poluentes Químicos da Água/toxicidade , Animais , Organismos Aquáticos , Ecotoxicologia , Monitoramento Ambiental/normas , Larva , Óvulo , Testes de Toxicidade Aguda/normas
4.
Aquat Toxicol ; 170: 1-12, 2016 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-26562184

RESUMO

Nickel compounds are widely used in industries and have been massively introduced in the environment in different chemical forms. Here we report the effect of two different chemical forms of nickel, NiCl2 and nickel nanoparticles (NiNPs), on the reproduction of the marine calanoid copepod Acartia tonsa. The behavior of nickel nanoparticles was analyzed with different techniques and with two protocols. In the "sonicated experiment" (SON) NiNP solution was sonicated while in the "non-sonicated experiment" (NON-SON) the solution was vigorously shaken by hand. Final nominal concentrations of 5, 10 and 50mgL(-1) and 1, 5 and 10mgL(-1) NiNPs were used for the acute and semichronic tests, respectively. Nanoparticle size did not change over time except for the highest concentration of 50mgL(-1) NiNPs, in which the diameter increased up to 843nm after 48h. The concentration of Ni dissolved in the water increased with NP concentration and was similar for SON and NON-SON solutions. Our results indicate that sonication does not modify toxicity for the copepod A. tonsa. Mean EC50 values were similar for NON-SON (20.2mgL(-1)) and SON experiments (22.14mgL(-1)) in the acute test. Similarly, no differences occurred between the two different protocols in the semichronic test, with an EC50 of 7.45mgL(-1) and 6.97mgL(-1) for NON-SON and SON experiments, respectively. Acute and semichronic tests, conducted exposing A. tonsa embryos to NiCl2 concentrations from 0.025 to 0.63mgL(-1), showed EC50 of 0.164 and 0.039mgL(-1), respectively. Overall, A. tonsa is more sensitive to NiCl2 than NiNPs with EC50 being one order of magnitude higher for NiNPs. Finally, we exposed adult copepods for 4 days to NiCl2 and NiNPs (chronic exposure) to study the effect on fecundity in terms of daily egg production and naupliar viability. Egg production is not affected by either form of nickel, whereas egg viability is significantly reduced by 0.025mgL(-1) NiCl2 and by 8.5mgL(-1) NiNPs. At NiNP concentration below the acute EC50 (17mgL(-1)) only 9% of embryos hatched after 4 days. Interestingly, the percentage of naupliar mortality (>82%) observed in the semichronic test at the nominal concentration of 10mgL(-1) NiNPs corresponding to almost 0.10mgL(-1) of dissolved Ni, was similar to that recorded at the same Ni salt concentration. Electron microscopical analyses revealed that A. tonsa adults ingest NiNPs and excrete them through fecal pellets. To the best of our knowledge, this is the first study investigating the toxicity of two different forms of Ni on the reproductive physiology of the copepod A. tonsa and showing the ability of the calanoid copepod to ingest nanoparticles from seawater.


Assuntos
Organismos Aquáticos/efeitos dos fármacos , Copépodes/efeitos dos fármacos , Nanopartículas/toxicidade , Níquel/toxicidade , Poluentes Químicos da Água/toxicidade , Animais , Bioensaio , Feminino , Nanopartículas/ultraestrutura , Tamanho da Partícula , Espectrofotometria Atômica , Eletricidade Estática , Testes de Toxicidade Aguda , Testes de Toxicidade Crônica
5.
Eur J Cancer ; 28A(8-9): 1480-4, 1992.
Artigo em Inglês | MEDLINE | ID: mdl-1515271

RESUMO

The relation between consumption of regular and decaffeinated coffee and other methylxanthine-containing beverages and bladder cancer was analysed in a case-control study in two different areas of northern Italy (555 cases and 855 controls). The multivariate relative risk (RR) adjusted for smoking, occupation and sociodemographic variables for coffee drinkers versus non-drinkers was 1.3 (95% CI 1.0-1.8). The RR was 1.2 for one cup of coffee per day, 1.4 for two, 1.5 for three and 1.4 for four or more (P = 0.05). RRs for current drinkers were 1.5 (0.9-2.4) for decaffeinated coffee, 0.9 (0.6-1.2) for tea, and 0.6 (0.3-1.4) for cola. With reference to duration of consumption of coffee, RRs were 1.2 for less than 30 years or 1.4 for 30 years or more. Coffee-related RRs were higher in the older age group and in ex-smokers. Among 105 cases and 338 controls who had never smoked, RRs were 1.9 for one or two cups per day, 1.8 for three and 1.5 for four or more (trend not significant). A higher prevalence of coffee drinking among bladder cancer cases than controls was confirmed, with no clear dose-risk relation.


Assuntos
Café/efeitos adversos , Neoplasias da Bexiga Urinária/induzido quimicamente , Idoso , Bebidas/efeitos adversos , Estudos de Casos e Controles , Feminino , Humanos , Itália/epidemiologia , Masculino , Pessoa de Meia-Idade , Análise Multivariada , Prevalência , Fatores de Risco , Fumar/efeitos adversos , Chá/efeitos adversos , Neoplasias da Bexiga Urinária/epidemiologia , Xantinas/efeitos adversos
6.
Ann Ostet Ginecol Med Perinat ; 111(4): 245-56, 1990.
Artigo em Italiano | MEDLINE | ID: mdl-2088156

RESUMO

The frequency and determinants of cesarean section rates in Italy were analyzed using data collected routinely by the Italian Central Institute of Statistics on more than 2,400,000 deliveries in 1980-83. The rate of cesarean section in Italy rose from 11.2/100 deliveries in 1980 to 14.5 in 1983. This increase was comparable with other European countries, although the rate of abdominal deliveries was still about 30-40% lower than in the United States and Canada. In the southern (and less rich) areas, the rate of cesarean section was about 40% lower than in the North or Centre of Italy. The rate of cesarean birth rose constantly with maternal age; being in comparison with teen-agers, about three times higher in women aged 45 years or more. Compared with women with primary or intermediate degree, those with university education reported about 40% higher rate of cesarean section, but this differences was markedly reduced after taking into account maternal age and birth weight. In southern areas of the country the frequency of cesarean birth was about 40% higher in public hospital than in private ones (11.5 and 8.1/100 deliveries, respectively), while in northern and central areas the frequency of cesarean birth was higher in private hospital than public ones (18.5 vs 14.7/100 deliveries in the North, and 19.6 vs 14.6/100 deliveries in the Centre). There were relationships between cesarean rates and birth weight or gestational weeks. The lowest values were observed in very low birth weight (less than or equal to 999 gr) as in babies weighing 3000-3999 gr and in deliveries occurred between the 25th and 27th gestational weeks and in term deliveries. About 55% of deliveries with breech presentation were delivered by cesarean section.


Assuntos
Cesárea/estatística & dados numéricos , Adolescente , Adulto , Fatores Etários , Peso ao Nascer , Canadá/epidemiologia , Europa (Continente)/epidemiologia , Feminino , Idade Gestacional , Humanos , Recém-Nascido , Itália/epidemiologia , Pessoa de Meia-Idade , Complicações do Trabalho de Parto/cirurgia , Gravidez , Complicações na Gravidez/cirurgia , Fatores Socioeconômicos , Estados Unidos/epidemiologia
7.
Br J Cancer ; 63(5): 769-72, 1991 May.
Artigo em Inglês | MEDLINE | ID: mdl-2039702

RESUMO

The relationship between various diseases and immunisations and the risk of multiple myeloma was analysed using data from a hospital-based case-control study conducted in Northern Italy on 117 patients with multiple myeloma and 477 controls. Associations were observed for clinical history of scarlet fever (relative risk, RR = 2.0; 95% confidence interval, CI = 1.1-3.9), tuberculosis (RR = 2.3%; 95% CI = 0.9-5.7) and BCG immunisation (RR = 3.0; 95% CI = 1.4-6.4). The relative risk was 1.8 (95% CI = 0.9-3.5) for episodes of Herpes zoster infection, but most of the excess cases occurred within 10 years of diagnosis, suggesting that this might have been an early manifestation of the disease. No association emerged for common childhood viral infections or any other immunisation practice. When various classes of infectious or inflammatory diseases were grouped together according to their aetiology, there was a significant positive association with chronic bacterial illnesses (RR = 1.8; 95% CI = 1.1-2.8), and the relative risk estimates increased with the number of bacterial diseases. The trend in risk with number of diseases was significant (chi 21 = 4.5, P = 0.03). A negative association was found between allergic conditions and risk of multiple myeloma (RR = 0.6; 95% CI = 0.3-1.0).


Assuntos
Mieloma Múltiplo/etiologia , Adulto , Idoso , Infecções Bacterianas/complicações , Estudos de Casos e Controles , Feminino , Humanos , Imunização , Itália/epidemiologia , Masculino , Pessoa de Meia-Idade , Mieloma Múltiplo/epidemiologia , Fatores de Risco , Viroses/complicações
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