[Protective effect of sodium hydroxybutyrate and mexamine on the body and cerebral cortex neurons during hypoxia]. / Zashchitnoe deistvie oksibutirata natriia, meksamina na organizm i neirony kory golovnogo mozga v usloviiakh gipoksii.

Experiments on white non-pure male mice have established that NA oxybutirate in doses 100 mg/kg and mexamine in doses 2.5 mg/kg possess antihypoxic properties in conditions of severe hypoxia corresponding to a height of 10 000 m. In a combined introduction of Na oxybutirate and mexamine in the above-mentioned doses there is an increase of their antihypoxic action. It was demonstrated that Na oxybutirate, mexamine and their combination exposes a distinct protective effect on the cortical neurons on rats in conditions of hypoxia. It is assumed that the protective action of the studied antihypoxants on the cortical neurons is realized with the aid of the same mechanisms as in a physiological adaptation to hypoxia.

[Effectiveness of hypoxic hypoxia as a means of protecting the body from ionizing radiation exposure with the use of sodium oxybutyrate and mexamine]. / Effektivnost' gipoksicheskoi gipoksii kak sposoba zashchity organizma ot vozdeistviia ioniziruiushchei radiatsii v usloviiakh primeneniia oksibutirata natriia i meksamina.

While exerting a pronounced antihypoxic action on the body of white mice under nypoxic hypoxia, a combination of sodium hydroxybutyrate and mexamine given in comparatively low doses (100 and 2.5 mg/kg, respectively) did not remove the radioprotective effect of hypoxic hypoxia. In hemic and histotoxic hypoxia the drugs did not exhibit any antihy-oxic action.

[Comparative study of the effectiveness of several antihypoxic agents and their combinations]. / Sravnitel'noe issledovanie éffektivnosti nekotorykh antigipoksantov i ikh kombinatsii

In 30--60 minutes following their administration sodium oxybutyrate in a dose of 100 mg/kg, mexamine in a dose of 2.5 and 5 mg/kg and also gutimine in doses of 25,50 and 100 mg/kg under conditions of hypoxic hypoxia corresponding to an altitude of 10000 m produce a marked antihypoxic effect. A combination of sodium oxybutyrate in the above dose, of mexamine in amounts of 1,2.5 and 5 mg/kg and also of gutimine in doses of 25,50 and 100 mg/kg permit it in some cases to achieve potentiation of antihypoxic effects of the drugs.

[Differences in the efficacy of gutimine alpha-ketoglutarate in the hypoxic and motor forms of hypoxia]. / O razlichii éffektivnosti al'fa-ketogliutarata gutimina pri gipoksicheskoi i dvigatel'noi formakh gipoksii.

When used in a dose of 100 mg/kg gutimine alpha-ketogluterate exerts a pronounced antihypoxic action in hypo- and normabaric hpoxic hypoxia ("lifting" albino mice in a pressure chamber to an "altitude" of 10000 m, rarefaction down to 198.7 mm of Hg, PO2--42 mm Hg, the chamber atmosphere containing 5.4 vol % of oxygen with the animals placed in the hermetically sealed chamber containing 5% of oxygen and 95% of nitrogen at 760 mm Hg). The absence of antihypoxic effect of the drug and exygen with the motor form of hypoxia (swimming test with the weight mass of 10 per cent of the body mass) bears evidence to the fact that the pathogenetic mechanisms in these two forms of hypoxia are dissimilar. An inference is drawn to the effect that the protective action of the drug may be associated with correction of the oxygen cycle in the organism.

[Study of antihypoxic properties and toxicity of mexamine (5-methoxytryptamine)]. / Izuchenie antigipoksicheskikh svoistv i toksichnosti meksamina (5-metoksitriptamina).

On its introduction to mongrel albino mice in doses of 1 to 200 mg/kg mexamine (5-methoxytryptamine) exerted a marked antihypoxic action in conditions of hypoxic hypoxia (a "rise" in the pressure chamber to an altitude of 8000 to 10 000 m) 5--180 minutes after administration of the drug. The possibility of reducing the toxicity of mexamine through preventive introduction of the agent in a dose of 1 mg/kg was established. With such a modification of the toxicity no mitigation of the antihypoxic effectiveness of the basic dose of the agent is observed.

[Effect of graded hypoxia and sodium oxybutyrate on the EEG of monkeys]. / Vliianie dozirovannoi gipoksii i oksibutirata natriia na EEG u obez'ian.

The effect on the EEG of a gaseous hypoxic mixture with 10 per cent of oxygen per se and with superimposed action of sodium oxybutyrate in a dose of 50 mg/kg was investigated in tests on macacas rhesus. Following introduction of sodium oxybutyrate an elimination of deviations from the initial EEG findings was registered.