Cascade-Dissipation Balance in Astrophysical Plasmas: Insights from the Terrestrial Magnetosheath.

The differential heating of electrons and ions by turbulence in weakly collisional magnetized plasmas and the scales at which such energy dissipation is most effective are still debated. Using a large data sample measured in Earth's magnetosheath by the magnetospheric multiscale mission and the coarse-grained energy equations derived from the Vlasov-Maxwell system, we find evidence of a balance over two decades in scales between the energy cascade and dissipation rates. The decline of the cascade rate at kinetic scales (in contrast with a constant one in the inertial range), is balanced by an increasing ion and electron heating rates, estimated via the pressure strain. Ion scales are found to contribute most effectively to ion heating, while electron heating originates from both ion and electron scales. These results can potentially impact the current understanding of particle heating in turbulent magnetized plasmas as well as their theoretical and numerical modeling.

Subion-Scale Turbulence Driven by Magnetic Reconnection.

The interplay between plasma turbulence and magnetic reconnection remains an unsettled question in astrophysical and laboratory plasmas. Here, we report the first observational evidence that magnetic reconnection drives subion-scale turbulence in magnetospheric plasmas by transferring energy to small scales. We employ a spatial "coarse-grained" model of Hall magnetohydrodynamics, enabling us to measure the nonlinear energy transfer rate across scale ℓ at position x. Its application to Magnetospheric Multiscale mission data shows that magnetic reconnection drives intense energy transfer to subion-scales. This observational evidence is remarkably supported by the results from Hybrid Vlasov-Maxwell simulations of turbulence to which the coarse-grained model is also applied. These results can potentially answer some open questions on plasma turbulence in planetary environments.

Allergy in adolescent population (14-18 years) living in Campania region (Southern Italy). A multicenter study.

Summary: Adolescents (Ad) constitute a difficult to manage population among individuals suffering from asthma. The aim of our study was to assess the prevalence, clinical characteristics and age of onset of allergic sensitization and clinical symptoms in a sample of atopic Ad living in the Campania region (Southern Italy). Sixteen Allergy units or Centers belonging to the Italian Association of Hospital and Territorial Allergologists (AAIITO, Campania region) participated in this cross-sectional study. A case report form (CRF) was specifically designed for this study and commercial allergen extracts used for screening SPTs were provided by ALK-Abelló Group (Milan, Italy). A total of 443 patients were examined (females, f 220, 49.6 %; males, m 223, 50.3%). Dust mites represent the most common sensitizing agents in allergic Ad living in Campania region (Dermatoph. pteronyssinus 67.4% and Dermatoph. farinae 66.5%), followed by Parietaria (58.9%), grasses (45.8%), Artemisia vulgaris (16.7%), Olea Europaea (32.2%), dog dander (17.1%), cat dander (20.0%), Alternaria alternata (8.1%), Cupressus sempervirens (4.9%), Betula pendula (4.7%), other allergens (19.4%). An interesting comparison has been made between clinical data of our Ad with data of elderly patients (E). The role of allergic sensitization is significantly higher in Ad compared to E. Dermatophagoides pteronyssinus is the first sensitizing allergen in Ad and the last in E. Parietaria constitutes the first sensitizing pollen both in Ad and E, the percentage of sensitization is higher in Ad. Another important difference is the higher prevalence of As, as only symptom, in E compared to Ad (19.7% versus 7.6%). In conclusion, our findings confirm the high prevalence and clinical significance of airway allergic sensitization in the adolescents living in Campania region.

Coherent Structures and Spectral Energy Transfer in Turbulent Plasma: A Space-Filter Approach.

Plasma turbulence at scales of the order of the ion inertial length is mediated by several mechanisms, including linear wave damping, magnetic reconnection, the formation and dissipation of thin current sheets, and stochastic heating. It is now understood that the presence of localized coherent structures enhances the dissipation channels and the kinetic features of the plasma. However, no formal way of quantifying the relationship between scale-to-scale energy transfer and the presence of spatial structures has been presented so far. In the Letter we quantify such a relationship analyzing the results of a two-dimensional high-resolution Hall magnetohydrodynamic simulation. In particular, we employ the technique of space filtering to derive a spectral energy flux term which defines, in any point of the computational domain, the signed flux of spectral energy across a given wave number. The characterization of coherent structures is performed by means of a traditional two-dimensional wavelet transformation. By studying the correlation between the spectral energy flux and the wavelet amplitude, we demonstrate the strong relationship between scale-to-scale transfer and coherent structures. Furthermore, by conditioning one quantity with respect to the other, we are able for the first time to quantify the inhomogeneity of the turbulence cascade induced by topological structures in the magnetic field. Taking into account the low space-filling factor of coherent structures (i.e., they cover a small portion of space), it emerges that 80% of the spectral energy transfer (both in the direct and inverse cascade directions) is localized in about 50% of space, and 50% of the energy transfer is localized in only 25% of space.

Local kinetic effects in two-dimensional plasma turbulence.

Using direct numerical simulations of a hybrid Vlasov-Maxwell model, kinetic processes are investigated in a two-dimensional turbulent plasma. In the turbulent regime, kinetic effects manifest through a deformation of the ion distribution function. These patterns of non-Maxwellian features are concentrated in space nearby regions of strong magnetic activity: the distribution function is modulated by the magnetic topology, and can elongate along or across the local magnetic field. These results open a new path on the study of kinetic processes such as heating, particle acceleration, and temperature anisotropy, commonly observed in astrophysical and laboratory plasmas.

Coupling between whistler waves and ion-scale solitary waves: cluster measurements in the magnetotail during a substorm.

We present a new model of self-consistent coupling between low frequency, ion-scale coherent structures with high frequency whistler waves in order to interpret Cluster data. The idea relies on the possibility of trapping whistler waves by inhomogeneous external fields where they can be spatially confined and propagate for times much longer than their characteristic electronic time scale. Here we take the example of a slow magnetosonic soliton acting as a wave guide in analogy with the ducting properties of an inhomogeneous plasma. The soliton is characterized by a magnetic dip and density hump that traps and advects high frequency waves over many ion times. The model represents a new possible way of explaining space measurements often detecting the presence of whistler waves in correspondence to magnetic depressions and density humps. This approach, here given by means of slow solitons, but more general than that, is alternative to the standard approach of considering whistler wave packets as associated with nonpropagating magnetic holes resulting from a mirror-type instability.

Local energy transfer and dissipation in incompressible Hall magnetohydrodynamic turbulence: The coarse-graining approach.

We derive the coarse-graining (CG) equations of incompressible Hall magnetohydrodynamic (HMHD) turbulence to investigate the local (in space) energy transfer rate as a function of the filtering scale ℓ. First, the CG equations are space averaged to obtain the analytical expression of the mean cascade rate. Its application to three-dimensional simulations of (weakly compressible) HMHD shows a cascade rate consistent with the value of the mean dissipation rate in the simulations and with the classical estimates based on the "third-order" law. Furthermore, we developed an anisotropic version of CG that allows us to study the magnitude of the cascade rate along different directions with respect to the mean magnetic field. Its implementation on the numerical data with moderate background magnetic field shows a weaker cascade along the magnetic field than in the perpendicular plane, while an isotropic cascade is recovered in the absence of a background field. The strength of the CG approach is further revealed when considering the local-in-space energy transfer, which is shown theoretically and numerically to match at a given position x, when locally averaged over a neighboring region, the (quasi-)local dissipation. Prospects of exploiting this model to investigate local dissipation in spacecraft data are discussed.

Two-dimensional kinetic turbulence in the solar wind.

We present the first 2D hybrid-Vlasov simulations of turbulence in the solar wind that describe the evolution of the energy spectra in a range of two decades of wavelengths around the ion inertial scale. Several previous magnetohydrodynamics and particle-in-cell simulations in the range of large (fluid) wavelengths showed a marked anisotropy of the energy spectra in the direction perpendicular to the mean magnetic field. Here we give evidence that the parallel direction can also be a privileged way for turbulence to develop towards short scales, where kinetic effects govern the plasma dynamics.

In situ spacecraft observations of a structured electron diffusion region during magnetopause reconnection.

The electron diffusion region (EDR) is the region where magnetic reconnection is initiated and electrons are energized. Because of experimental difficulties, the structure of the EDR is still poorly understood. A key question is whether the EDR has a homogeneous or patchy structure. Here we report Magnetospheric Multiscale (MMS) spacecraft observations providing evidence of inhomogeneous current densities and energy conversion over a few electron inertial lengths within an EDR at the terrestrial magnetopause, suggesting that the EDR can be rather structured. These inhomogenenities are revealed through multipoint measurements because the spacecraft separation is comparable to a few electron inertial lengths, allowing the entire MMS tetrahedron to be within the EDR most of the time. These observations are consistent with recent high-resolution and low-noise kinetic simulations.

Pressure anisotropy and small spatial scales induced by velocity shear.

By including the full pressure tensor dynamics in a fluid plasma model, we show that a sheared velocity field can provide an effective mechanism that makes the initial isotropic pressure nongyrotropic. This is distinct from the usual gyrotropic anisotropy related to the fluid compressibility and usually accounted for in double-adiabatic models. We determine the time evolution of the pressure agyrotropy and discuss how the propagation of "magnetoelastic perturbations" can affect the pressure tensor anisotropization and its spatial filamentation, which are due to the action of both the magnetic field and the flow strain tensor. We support this analysis with a numerical integration of the nonlinear equations describing the pressure tensor evolution.

Impact of kinetic processes on the macroscopic nonlinear evolution of the electromagnetic-beam-plasma instability

We present a new, fully kinetic mechanism of generation of spatial magnetic vortices that results from the resonant wave-particle interaction in a plasma. This phenomenon is of basic theoretical interest. It can be responsible for the magnetic vortices observed in numerical simulations in the wake of an ultrastrong, ultraintense laser pulse in an underdense plasma.

Propagation of a short proton beam through a thin plasma slab.

A one-dimensional open boundary Vlasov code is used in order to investigate the propagation of a short proton beam through a plasma slab. Collisionless regimes are assumed, where the interaction between the beam and the plasma occurs due to the self-consistent, collective, electric field. Both charge compensated (by an accompanying electron cloud) and noncompensated beams are considered.

Clinical importance of thrombomodulin serum levels.

Thrombomodulin is a glycoprotein that can bind to thrombin and activate protein C, thus mitigating the effects of cytokines produced by inflammatory and immunological processes. The molecule exerts a protective function on endothelial cells. Thrombomodulin is cleaved to its soluble form by neutrophil elastase and by other substances produced during acute and chronic inflammatory responses, immunologic reactions and complement activation. ELISA technique yields normal serum levels of 3.1 +/- 1.3 ng/ml; in males these levels are higher; TM levels also rise during menopause. Other circumstances associated with an increase of serum TM levels are smoking, disseminated intravascular coagulation (DIC), cardiac surgery, atherosclerosis, ARDS, liver cirrhosis, diabetes mellitus, cerebral and myocardial infarction, and multiple sclerosis. Serum levels of TM represent an useful prognostic index, because they are associated with an increase in mortality rate, or however a progression of the underlying pathological condition.

Adrenomedullin assay and its clinical significance.

Adrenomedullin (Am) is a recently discovered peptide, first purified from pheochromocytoma specimens, with a chemical structure similar to that of CGRP and amylin. Adrenomedullin is present in numerous human body tissues and its powerful vasodilatatory activity is thought to play an essential role in cardiovascular and renal homeostasis.

CGRP and ET-1 plasma levels in normal subjects.

OBJECTIVE: Calcitonin gene-related peptide (CGRP) is a 37 amino acid peptide displaying about 50% homology with amylin which is secreted from the pancreatic islets of Langerhans. The main form, the beta-CGRP, is produced by the enteric nervous system and perivascular nerves of the vasa-vasorum. It represents one of the most powerful vasodilator yet discovered but its role is not yet completely clarified. High levels of this peptide have been shown in patients affected with thyroid medullary carcinoma, phaemocromocytoma and lung carcinoma. Recently circulating levels of CGRP have been found in normal subjects. Endothelin-1 (ET-1), a potent vasoconstrictor peptide, isolated from porcine endothelial cells, is an important regulator of the vascular tone acting in physiological antagonism with atrial natriuretic hormone (ANH). With this study we intended to investigate the presence of any correlation between CGRP and ET-1 in normal subjects. PATIENTS: For the study we considered 20 normal subjects (11 males and 9 females) aged 23 to 50. MEASURES: Plasma levels of CGRP and ET-1 were measured by radioimmunological Kit. RESULTS: A positive and significant correlation between calcitonin gene-related peptide and endothelin-1 was found. CONCLUSIONS: Our results confirms that CGRP and ET-1 have opposing actions on vessels and that they can act together in haemodinamic regulation.

Mitral prolapse. A heart anomaly in a clinical neuroendocrine context.

Mitral valve prolapse was identified as a separate nosological entity by Barlow in 1963. A characteristic of this cardiac anomaly is blood reflux into the left atrium during the systole owing to the lack of adhesion between valve flaps. The presence of symptoms linked to neuroendocrine dysfunctions or to the autonomic nervous system lead to the onset of the pathology known as mitral valve prolapse syndrome (MVPs). It is usually diagnosed by chance in asymptomatic patients during routine tests. MVPs includes complex alterations to the neurovegetative system and a high clinical incidence of neuropsychiatric symptoms, like anxiety and panic attacks. A neuroendocrine mechanism thought to underlie panic attacks was recently proposed based on a biological model. In general, the cardiovascular anomaly manifested by patients with MVPs could be defined in neuroendocrine-constitutional terms.

Time window for magnetic reconnection in plasma configurations with velocity shear.

It is shown that the rate of magnetic field line reconnection can be clocked by the evolution of the large-scale processes that are responsible for the formation of the current layers where reconnection can take place. In unsteady plasma configurations, such as those produced by the onset of the Kelvin-Helmholtz instability in a plasma with a velocity shear, qualitatively different magnetic structures are produced depending on how fast the reconnection process develops on the external clock set by the evolving large-scale configuration.

Competing mechanisms of plasma transport in inhomogeneous configurations with velocity shear: the solar-wind interaction with earth's magnetosphere.

Two-dimensional simulations of the Kelvin-Helmholtz instability in an inhomogeneous compressible plasma with a density gradient show that, in a transverse magnetic field configuration, the vortex pairing process and the Rayleigh-Taylor secondary instability compete during the nonlinear evolution of the vortices. Two different regimes exist depending on the value of the density jump across the velocity shear layer. These regimes have different physical signatures that can be crucial for the interpretation of satellite data of the interaction of the solar wind with the magnetospheric plasma.