Infectious complications after allogeneic hematopoietic stem cell transplantation in children in a bone marrow transplant unit in Colombia.

OBJECTIVE: There is a relative lack of information about infections occurring in children following allogeneic hematopoietic stem cell transplants (allo-HSCT) in developing countries. Herein, we describe the incidence rates of different infections according to the transplant period and baseline condition in Colombia. METHODS: In a retrospective cohort study of all children who underwent allo-HSCTs from 2012 to 2017 in a hospital in Cali, Colombia, we reviewed medical records from the first post-transplant day until day + 365 to describe microbiologically confirmed incidence rates of infections and deaths during three post-transplant periods and according to baseline condition. RESULTS: Most allo-HSCT (n = 144, 96%) were followed by infections over the following year, mostly due to bacteria and cytomegalovirus (4.3 and 3.3 per 1000 patient-days, respectively). Children were at the highest risk for infection in the first 30 days post-HSTC, but mortality was highest after 100 days. Overall, high mortality (n = 44, 31.7%) was associated with infections, especially from extensively drug-resistant bacteria, adenovirus, and aspergillosis. Infection rates were similar independent of the baseline condition. CONCLUSION: Almost all children in this cohort developed infections post allo-HSCT. Describing the distribution of infections throughout the first post allo-HSCT year allows clinicians to narrow the differential diagnosis of infections according to the post-transplant period. This is especially useful when prioritizing interventions in children receiving HSCT in stringent healthcare systems in developing countries.

Techno-economic assessment of quinoa production and transformation in Morocco.

Agriculture is facing many challenges as climate change, drought, and salinity which call for urgent interventions to fast adaptation and diversification such as the introduction of new climate smart and stress tolerant crops such as quinoa. This study aims to introduce new high yielding quinoa cultivars conducted under several agronomic practices (rainfed, irrigation, and organic amendment) and to assess the technical and economic aspects related to quinoa seed production, transformation, and quality. Results obtained from agronomic trials clearly showed that International Center for Biosaline Agriculture cultivars recorded higher yields than locally cultivated seeds. Irrigation and organic amendment had a tremendous effect on quinoa productivity as it increased most of cultivar's yield by more than three times compared with rainfed conditions. Production cost analysis showed that using mechanized production and processing practices combined with irrigation and organic amendment can reduce seed production and processing cost from 2.8 to 1.2 USD kg-1 compared with manual production system under rainfed conditions. The diagnosis of the quinoa transformation pathways revealed different transformation levels, and the production cost increased with the level of transformation due to high cost of labor and raw material. Analysis of quinoa seeds showed that macronutrient content is mostly not affected by pearling process, while micronutrients content was significantly decreased in processed seeds. In addition, total saponin content was reduced to an acceptable level after using mechanical pearling compared with manual abrasion.