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We report preventive measures adopted after tuberculosis(TB) transmission from a nurse to a newborn assessed in late July 2011. All exposed neonates born between January and July 2011 were clinically evaluated and tested by QuantiFERON TB gold in-tube; newborns testing positive were referred for prophylaxis.Of 1,340 newborns, 118 (9%) tested positive and no other active cases of TB were found. Active surveillance for TB will be continued over the next three years for all those exposed.
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Surtos de Doenças , Hospitais Pediátricos , Hospitais Universitários , Transmissão de Doença Infecciosa do Profissional para o Paciente , Enfermagem Materno-Infantil , Unidade Hospitalar de Ginecologia e Obstetrícia , Tuberculose Pulmonar/transmissão , Tuberculose Esplênica/transmissão , Adulto , Antituberculosos/uso terapêutico , Busca de Comunicante , Saúde da Família , Feminino , Humanos , Imunidade Celular , Lactente , Recém-Nascido , Transmissão de Doença Infecciosa do Profissional para o Paciente/prevenção & controle , Interferon gama/metabolismo , Masculino , Programas de Rastreamento , Mycobacterium tuberculosis/isolamento & purificação , Vigilância da População , Gravidez , Cidade de Roma/epidemiologia , Escarro/microbiologia , Teste Tuberculínico , Tuberculose Pulmonar/epidemiologia , Tuberculose Pulmonar/prevenção & controle , Tuberculose Esplênica/prevenção & controleRESUMO
OBJECTIVE: To develop a deep learning-based decision tree for the primary care setting, to stratify adult patients with confirmed and unconfirmed coronavirus disease 2019 (COVID-19), and to predict the need for hospitalization or home monitoring. PATIENTS AND METHODS: We performed a retrospective cohort study on data from patients admitted to a COVID hospital in Rome, Italy, between 5 March 2020 and 5 June 2020. A confirmed case was defined as a patient with a positive nasopharyngeal RT-PCR test result, while an unconfirmed case had negative results on repeated swabs. Patients' medical history and clinical, laboratory and radiological findings were collected, and the dataset was used to train a predictive model for COVID-19 severity. RESULTS: Data of 198 patients were included in the study. Twenty-eight (14.14%) had mild disease, 62 (31.31%) had moderate disease, 64 (32.32%) had severe disease, and 44 (22.22%) had critical disease. The G2 value assessed the contribution of each collected value to decision tree building. On this basis, SpO2 (%) with a cut point at 92 was chosen for the optimal first split. Therefore, the decision tree was built using values maximizing G2 and LogWorth. After the tree was built, the correspondence between inputs and outcomes was validated. CONCLUSIONS: We developed a machine learning-based tool that is easy to understand and apply. It provides good discrimination in stratifying confirmed and unconfirmed COVID-19 patients with different prognoses in every context. Our tool might allow general practitioners visiting patients at home to decide whether the patient needs to be hospitalized.
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Algoritmos , COVID-19/diagnóstico , COVID-19/terapia , Árvores de Decisões , Serviços de Assistência Domiciliar/estatística & dados numéricos , Hospitalização/estatística & dados numéricos , Idoso , COVID-19/epidemiologia , COVID-19/virologia , Teste para COVID-19 , Estudos de Coortes , Tomada de Decisões Assistida por Computador , Feminino , Seguimentos , Humanos , Itália/epidemiologia , Aprendizado de Máquina , Masculino , Monitorização Fisiológica , Prognóstico , Estudos Retrospectivos , SARS-CoV-2/isolamento & purificaçãoRESUMO
OBJECTIVE: The aim of this study is to collect the two years' data regarding the Integrated Trauma Management System (SIAT) by capturing the activity of its three Hubs in the Italian Lazio Region and test the performance of one of the Hubs' (Fondazione Policlinico Universitario A. Gemelli - IRCCS, FPG -IRCCS) Major Trauma Clinical Pathway's (MTCP) monitoring system, introducing the preliminary results through volume, process and outcome indicators. MATERIALS AND METHODS: A retrospective analysis on SIAT was conducted on years 2016 to 2018, by collecting outcome and timeliness indicators through the Lazio Informative System whereas the MTCP was monitored through set of indicators from the FPG - IRCCS Informative System belonging to randomly selected clinical records of the established period. RESULTS: Hubs managed 11.3% of the 998,240 patients admitted in SIAT. All patients eligible for MTCP were "Flagged", and 83% underwent a CT within 2 hours; intra-hospital mortality was 13% whereas readmission rates 16.9%. CONCLUSIONS: SIAT converges the most severe patients to its Hubs. The MTCP monitoring system was able to measure a total of 9 out of 13 indicators from the original panel. This research may serve as a departing point to conduct a pre-post analysis on the performance of the MTCP.
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Procedimentos Clínicos/organização & administração , Prestação Integrada de Cuidados de Saúde/organização & administração , Planejamento Hospitalar/organização & administração , Avaliação de Processos e Resultados em Cuidados de Saúde/organização & administração , Centros de Traumatologia/organização & administração , Ferimentos e Lesões/terapia , Adolescente , Adulto , Idoso , Criança , Pré-Escolar , Feminino , Mortalidade Hospitalar , Humanos , Lactente , Recém-Nascido , Masculino , Pessoa de Meia-Idade , Readmissão do Paciente , Indicadores de Qualidade em Assistência à Saúde/organização & administração , Estudos Retrospectivos , Cidade de Roma , Fatores de Tempo , Tempo para o Tratamento/organização & administração , Resultado do Tratamento , Triagem/organização & administração , Ferimentos e Lesões/diagnóstico , Ferimentos e Lesões/mortalidade , Adulto JovemRESUMO
OBJECTIVE: Delays in patient discharge can adversely affect hospital and emergency room productivity and increase healthcare costs. The discharge should be structured from the hospital admission towards the most appropriate environment. This study aims to investigate the efficacy of the Unit, named "Continuity of Care Center" (CCC), to guarantee a safest and fastest hospital discharge in frail patients and to test the effect of our team-approach on hospital outcomes (length of stay and hospital mortality). MATERIALS AND METHODS: This is a prospective cohort study carried out in an acute care hospital with 1,558 beds and is equipped with 41 operating theaters. We collected data from October 2016 to June 2019. RESULTS: The time of patient discharge had an important reduction: 15.5±30.8 in the first 3 months vs. 11.0±20.1 in the last 3 months considered. The median of the time of discharge in all 12 months considered was 12 day. The length of stay presented an important reduction from 33.3±47.5 during the first 3 months vs. 28.8±39.5 in the last 3 months of activity of CCC; and a significant reduction of hospital deaths was recorded from 20% during the first 3 months to 14% in the last 3 months of activity of CCC. CONCLUSIONS: Results indicate a constant decrease in patient discharge time and length of hospital stay, with a consequent significant reduction of healthcare costs. According to the estimates of Italian Health Ministry concerning Latium region, every hospitalization day has a mean cost of 674.00. Thus, the CCC activity has contributed to a reduction of approximately 12,832 days of hospitalization, in the considered period, with an estimated hospital saving of 8,648,761.
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Idoso Fragilizado , Cuidados Paliativos na Terminalidade da Vida/economia , Hospitalização/economia , Tempo de Internação/economia , Modelos de Enfermagem , Alta do Paciente/economia , Idoso , Estudos de Coortes , Feminino , Mortalidade Hospitalar , Humanos , Pacientes Internados , Masculino , Estudos ProspectivosRESUMO
INTRODUCTION: The systematic evaluation of the quality of medical records is crucial. Nevertheless, even if the improvement of medical records quality represents a priority for every health organization, it might be difficult to realize.This is the first study to assess the efficacy of internal audit as a tool to improve the quality of medical records in hospital setting. METHODS: The program was carried out in a third level teaching hospital. Trained ad hoc evaluation teams carried out two retrospective assessments of quality of medical records using a random sampling strategy. The quality assessment was performed using a 48-items evaluation grid divided into 9 domains: General; Patient Medical History and Physical Examination; Daily Clinical Progress Notes; Daily Nursing Progress Notes; Drug Therapy Chart; Pain Chart; Discharge Summary; Surgery Register; Informed Consent. After the first evaluation of 1.460 medical records, an audit departmental program was set up. The second evaluation was carried out after the internal auditing for 1.402 medical records. RESULTS: Compared to the first analysis, a significant quality amelioration in all the sections of the medical chart was shown with the second analysis, with an increase of all the scores above 50%. The differences found for each section of medical records between the first and second analysis are all significant (p<0.01). CONCLUSIONS: Internal audits are not just measurement activities but a necessary activity to support the organization in achieving its objectives and assessing the quality of clinical care and maintaining high quality professional performance.
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Auditoria Clínica , Documentação/normas , Hospitais de Ensino , Prontuários Médicos/normas , Melhoria de Qualidade , Humanos , Itália , Estudos RetrospectivosRESUMO
In a context of continuous spread health technologies, in which particular intensive procedures are performed, the use of procedure volume indicators supports the decision making process in monitoring and improving the healthcare quality. The aim of our work focuses on the evaluation of the association between the volume of procedures performed by organizational units inside an Italian University Hospital and the results in terms of mortality and prolonged length of stay (LOS). Volume indicators concerning esophageal resection, pancreatic resection, abdominal aortic aneurysm repair, coronary artery bypass graft and percutaneous transluminal coronary angioplasty were analysed according to the Agency of Health Care Research and Quality's criteria. A retrospective observational study was conducted analysing hospital discharged databases and operating room records for the period 2000-2005. Descriptive and inferential statistical analysis were performed using SPSS software 13.0 version. Regarding prolonged LOS, a statistical significant difference emerged among high and low volume organizational units for pancreatic resections, bypass, and angioplasty with respectively adjusted OR at 2.4 (C.I. 95% 1.04-5.53); 1.67 (C.I. 95% 1.29-2.16) and 3.34 (CI 95% 2.60-4.28). For mortality, a statistical significant difference emerged for abdominal aortic aneurysm repair and bypass with respectively OR at 21.02 (C.I. 95% 2.22-199.64) and 26.55 (C.I. 95% 15.30 - 46.07). The use of procedure volume indicators could help hospital administrators and medical professionals balance competing values such as control of cost and continuous quality improvement.
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Mortalidade Hospitalar , Hospitais de Ensino/estatística & dados numéricos , Tempo de Internação/estatística & dados numéricos , Procedimentos Cirúrgicos Operatórios/estatística & dados numéricos , Humanos , Itália , Estudos RetrospectivosRESUMO
OBJECTIVES: To perform a 3-year, prospective surveillance program for legionnaires disease (LD) in a large university hospital in Rome, and to assess the usefulness of the hospital water monitoring program in predicting the risk of nosocomial LD. METHODS: Samples from patients with new cases of nosocomial pneumonia were sent for legionella laboratory investigations. Meanwhile, water samples for bacteriological analysis were collected every 6 months from high- and medium-risk hospital wards (10 in total). Legionella pneumophila isolates collected were serotyped and analyzed by pulsed-field gel electrophoresis. RESULTS: From June 2001 through May 2004, the pneumonia surveillance identified one case of nosocomial LD among 43 cases of nosocomial pneumonia (2.3%). Environmental investigations detected L. pneumophila in 12 (18.7%) of the 64 water samples, of which 50% belonged to serogroup 1. The L. pneumophila count and the percentage of positive locations never exceeded 10(2) colony-forming units/L and 20%, respectively, except when the LD nosocomial case occurred (positive water samples, 40%; L. pneumophila count, <10(2) colony-forming units/L). Genotyping showed 3 prevalent clones of L. pneumophila in the water distribution network, of which one persisted over the 3 years. One clone contained 3 different L. pneumophila serogroups (2, 4, and 6). CONCLUSIONS: The low incidence of nosocomial cases of LD appears to be associated with a low percentage (<20%) of positive water samples per semester and with a low contamination level (<10(2) colony-forming units/L). An infection control system for nosocomial LD should, therefore, be based on both environmental and clinical surveillance, together with the appropriate maintenance of the hospital water distribution system.
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Infecção Hospitalar/epidemiologia , Água Doce/microbiologia , Legionella pneumophila/isolamento & purificação , Doença dos Legionários/epidemiologia , Vigilância da População , Abastecimento de Água , Infecção Hospitalar/microbiologia , Eletroforese em Gel de Campo Pulsado , Hospitais Universitários , Humanos , Incidência , Controle de Infecções/métodos , Legionella pneumophila/classificação , Legionella pneumophila/genética , Doença dos Legionários/microbiologia , Estudos ProspectivosRESUMO
Our main purpose was to evaluate the organizational appropriateness of admissions made in a university hospital, by comparing two iso-gravity classification systems, APR-DRG and Disease Staging, with the Italian version of AEP (PRUO). Our analysis focused on admissions made in 2001, related to specific Diagnosis Related Groups (DRGs), which, according an Italian Law, would be considered at high risk of inappropriateness, if treated as ordinary admissions. The results obtained by using the 2 classification systems did not show statistically significant differences with respect to the total number of admissions. On the other hand, some DRGs showed statistically significant differences due to different algorithms of attribution of the severity levels used by the two systems. For almost all of the DRGs studied, the AEP-based analysis of a sample of medical records showed an higher number of inappropriate admissions in comparison with the number expected by iso-gravity classification methods. The difference is possibly due to the percentage limits of tolerability fixed by the Law for each DRG. Therefore, the authors suggest an integrated use of the two methods to evaluate organizational appropriateness of hospital admissions.
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Grupos Diagnósticos Relacionados , Hospitais Universitários/organização & administração , Admissão do Paciente/normas , Índice de Gravidade de Doença , Mau Uso de Serviços de Saúde , Hospitalização/estatística & dados numéricos , Hospitais Universitários/estatística & dados numéricos , Humanos , Itália , Admissão do Paciente/estatística & dados numéricosRESUMO
Staphylococcus aureus strains generally colonize eczematous lesions of subjects with atopic dermatitis much more frequently than in the skin of normal individuals. The aim of this study was to provide a detailed genotypic and phenotypic analysis of S. aureus strains colonizing four different sites (lesional and non-lesional skin areas, nasal and pharyngeal mucosas) of 49 patients with atopic dermatitis. The 88 isolates were analyzed in duplicate by pulsed field gel electrophoresis and in their exfoliative toxin A or B production by latex test. The patients were characterized by age, sex, severity scoring of atopic dermatitis and serum eosinophil cationic protein. Fourteen (28.6%) of the patients were completely negative for S. aureus while 35 (71.4%) were positive in at least one site. The severity scores and eosinophil cationic protein levels were significantly correlated variables (P<0.001), linked to the colonization intensity (P ranging between 0.05 and <0.001 depending on the site) and to the number of colonized sites (P at least <0.01). The genotypic patterns, widely heterogeneous, showed no restriction to peculiar patterns. Only eight strains produced exfoliative toxin B which was significantly restricted to the lesional isolates (P=0.012).
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Dermatite Atópica/microbiologia , Ribonucleases , Staphylococcus aureus/genética , Staphylococcus aureus/patogenicidade , Adolescente , Adulto , Proteínas Sanguíneas/metabolismo , Criança , Pré-Escolar , Contagem de Colônia Microbiana , Dermatite Atópica/sangue , Eletroforese em Gel de Campo Pulsado , Proteínas Granulares de Eosinófilos , Exfoliatinas/biossíntese , Feminino , Genótipo , Humanos , Lactente , Masculino , Pessoa de Meia-Idade , Fenótipo , Staphylococcus aureus/isolamento & purificaçãoRESUMO
The purpose of this study was to investigate the usefulness of different molecular typing techniques in the surveillance and control of the spread of extended-spectrum-beta-lactamase-(ESBL) producing Klebsiella pneumoniae in the pediatric department of the "Agostino Gemelli" hospital of the Catholic University in Rome, over a period of nine months. The strains were characterized by ribotyping using HindIII as restriction enzyme and pulsed field gel electrophoresis (PFGE) using XbaI as endonuclease. Sixty six K. pneumoniae clinical strains were isolated during this period, the first 32 were isolated in the summer of 1998. Among these first isolates, ribotyping generated 26 different patterns whereas PFGE produced 16 patterns. The remaining 34 strains were isolated during January and April 1999 and all of them were ESBL producers. Ribotyping clustered the strains into 6 patterns whereas PFGE generated only 3 patterns. PCR revealed the presence in 10 isolates of both bla(TEM) and bla(SHV) genes and 24 strains carried only the bla(SHV) gene. In our experience ribotyping revealed a higher power of differentiation with respect to PFGE and was of great help in the surveillance of the infection.
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Infecções por Klebsiella/microbiologia , Klebsiella pneumoniae/classificação , Klebsiella pneumoniae/genética , Infecção Hospitalar/microbiologia , Primers do DNA/química , DNA Bacteriano/química , Desoxirribonuclease HindIII/química , Desoxirribonucleases de Sítio Específico do Tipo II/química , Resistência Microbiana a Medicamentos , Eletroforese em Gel de Campo Pulsado , Humanos , Processamento de Imagem Assistida por Computador , Unidades de Terapia Intensiva Neonatal , Infecções por Klebsiella/sangue , Infecções por Klebsiella/urina , Klebsiella pneumoniae/química , Klebsiella pneumoniae/efeitos dos fármacos , Testes de Sensibilidade Microbiana , Filogenia , Reação em Cadeia da Polimerase , Estudos Prospectivos , Ribotipagem , Infecções Urinárias/microbiologiaRESUMO
The behaviour of the serum levels of thyroxine (T4), 3,5,3' tri-iodothyronine (T3), TSH and of the free binding sites of the thyroid hormones binding globulins in 23 patients affected by hepatic cirrhosis, is described in function of the severity of the disease. The values obtained have been statistically compared to those of a group of 14 healthy subjects. A decrease of the serum levels of T3 directly related to the severity of the disease has been remarked in the cirrhotic patients, while no significant differences in the serum levels of T4 and TSH and in the number of free binding sites on the thyroid hormones binding globulins have been noted between the two groups.
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Cirrose Hepática/sangue , Hormônios Tireóideos/sangue , Adolescente , Adulto , Idoso , Doença Crônica , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Prognóstico , Ligação Proteica , Tireotropina/sangue , Tiroxina/sangue , Tri-Iodotironina/sangueRESUMO
The aim of the study was to assess the appropriateness of the provision of surgical treatment in the day hospital setting and at the same time to evaluate the efficacy of the service provided. The study was conducted on admissions to a day care unit operating in conjunction with the surgery division of a university hospital. The evaluation of appropriateness was carried out using explicit criteria, based on regional regulations and on guidelines drawn up by the Agency for Regional Health Services. The criteria related to the hospital bed equivalent Rotation Index and to the types of DRGs treated and services provided. Efficacy was assessed using the following para-meters: number of US-guided fine needle aspiration biopsies; techniques used; age, sex and nodule size; patient distribution by results of diagnostic examination; cytological classification; percentage of patients with complications. We also evaluated the possibility of transferring short-term (2-3 days) surgical admissions from ordinary regimens to the day care setting. The results of this study yield useful synthetic indicators for assessing the appropriateness both of the day care function as a whole and of individual operating units, providing both administrative and medical staff with a useful frame of reference for the planning of health-care management.
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Procedimentos Cirúrgicos Ambulatórios/normas , Doenças do Sistema Endócrino/cirurgia , Adulto , Idoso , Idoso de 80 Anos ou mais , Feminino , Hospitais Universitários , Humanos , Itália , Masculino , Pessoa de Meia-IdadeRESUMO
Health care processes and services of the "Policlinico" are analyzed with respect to their performance. Possible improvement is identified in reducing the process overall time at the process-service interface.
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Departamentos Hospitalares/organização & administração , Reestruturação Hospitalar/organização & administração , Hospitais de Ensino/organização & administração , Serviços Centralizados no Hospital/organização & administração , Prestação Integrada de Cuidados de Saúde/organização & administração , Serviços de Diagnóstico/organização & administração , Eficiência Organizacional , Serviço Hospitalar de Emergência/organização & administração , Reforma dos Serviços de Saúde , Unidades Hospitalares/organização & administração , Humanos , Itália , Laboratórios Hospitalares/organização & administração , Salas Cirúrgicas/organização & administração , Inovação Organizacional , Avaliação de Processos e Resultados em Cuidados de Saúde , Ambulatório Hospitalar/organização & administração , Assistência Centrada no Paciente , Técnicas de Planejamento , Centro Cirúrgico Hospitalar/organização & administraçãoRESUMO
The "immigrants problem", with the inevitable social aspects which this new phenomenon involves, has grown lately into a matter of primary interest to the public opinion of our country. The hospital too, in its capacity as leader among the sociosanitary institutions, has witnessed a change to some extent of the demand for services resulting from this reality. The Authors intend therefore to re-define here the whole body of a large metropolitan hospital patients, referring to an extensive statistical information and analyzing with special attention the statistics about foreign citizens. To this purpose they have considered all the cases of hospitalization occurred during a five-year period, from 1985 to 1989. The gathered data have been elaborated and analyzed from a more strictly demographic standpoint and (in particular) from the epidemiological point of view, comparing the data resulting among the immigrants with those regarding the whole body of hospitalized people during the same period. The data so obtained show, in spite of some significant differences due almost certainly to social differences, a superimposition on the italian reality, reproducing on a smaller scale its distinctive features. Even if this research is restricted to a specific situation, the results obtained can be considered a basis to make further similar studies within other hospital structures, in order to point out the different and variable demands for hospital services originating from this new social reality.
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Emigração e Imigração , Hospitais Urbanos , Morbidade , Pacientes , Adolescente , Adulto , Fatores Etários , Idoso , Idoso de 80 Anos ou mais , Criança , Feminino , Humanos , Itália , Tempo de Internação , Masculino , Pessoa de Meia-Idade , Gravidez , Fatores SexuaisRESUMO
Italian version of Appropriateness Evaluation Protocol (AEP) is a tool for evaluating the appropriateness of hospitalization for acute patients. In particular, it aims to verify and quantify the reasons of appropriateness associated to the day of admission and the single days of hospital stay. The aim of the present paper is to evaluate the appropriateness of ordinary, 2-3 days lasting, hospital admissions within an university hospital. We examined a sample of 518 hospital admissions: 370 admissions (71%) lasting 2 days, and 148 admissions (29%) lasting 3 days. Results analysis showed different levels of appropriateness between the 2-days and the 3-days admissions: the appropriate admissions were 18% in the sample of the 2-days admissions and 38% in the sample of 3-days admissions. Most inappropriate days of admission and stay in hospital are due to attended or to the execution of diagnostic procedures. In order to evaluate accuracy by means of AEP methodology, it is necessary to improve the quality of medical documentation using standardized medical records. AEP, in the framework of the continuous quality improvement, is a valid tool to reorganise health care processes.
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Grupos Diagnósticos Relacionados , Hospitalização , Hospitais Universitários , Tempo de Internação , Revisão da Utilização de Recursos de Saúde , Hospitais Universitários/estatística & dados numéricos , Humanos , Itália , Fatores de TempoRESUMO
BACKGROUND: Pivotal studies indicate a role of excision repair cross-complementation 1 (ERCC1) gene and ribonucleotide reductase M1 (RRM1) gene in conferring a differential sensitivity to cytotoxic chemotherapy and epidermal growth factor receptor (EGFR) gene has been recently extensively investigated in non-small-cell lung cancer (NSCLC). DESIGN: Formalin-fixed, paraffin-embedded bronchoscopic/fine needle aspiration biopsies obtained from 70 patients with advanced NSCLC were retrospectively collected to investigate the expression level of ERCC1, RRM1 and EGFR by real-time PCR. Sufficient amounts of messenger RNA (mRNA) were successfully extracted from 61 (87%) specimens, reverse transcribed and amplified with intron-spanning primers. Forty-one patients had stage IV disease and 43 received cisplatin/gemcitabine chemotherapy. RESULTS: A strong correlation between ERCC1 and RRM1 mRNA levels (r(s) = 0.624, P < 0.0001) was found. Median survival time in patients with low ERCC1 was significantly longer (17.3 versus 10.9, P = 0.0032 log-rank test) as well as in patients with low RRM1 (13.9 versus 10.9, P = 0.0390 log-rank test). Concomitant low expression levels of ERCC1 and RRM1 (n = 33) were predictive of a better outcome (14.9 versus 10.0, P = 0.0345 log-rank test). Among cisplatin-treated patients, a low ERCC1 level was highly predictive of a longer survival (23.0 versus 12.4, P = 0.0001 log-rank test). No correlation between gene expression levels and histology was reported. No significant correlation between EGFR expression level and survival was found. At multivariate analysis, performance status, response to chemotherapy, presence of weight loss and ERCC1 were independent prognostic factors for survival. CONCLUSIONS: This retrospective study further validates ERCC1 and RRM1 genes as reliable candidates for customized chemotherapy and shows a higher impact on the survival of NSCLC patients treated with cisplatin/gemcitabine for ERCC1. Prospective pharmacogenomic studies represent a research priority in early and advanced NSCLC.