Detalhe da pesquisa
1.
Discovery of potent small-molecule inhibitors of lipoprotein(a) formation.
Nature
; 629(8013): 945-950, 2024 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-38720069
2.
Carcinogenicity assessment of baricitinib in Tg.rasH2 mice and Sprague-Dawley (Crl:CD) rats.
Regul Toxicol Pharmacol
; 92: 458-471, 2018 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-29203403
3.
Effect of hepatic or renal impairment on the pharmacokinetics of evacetrapib.
Eur J Clin Pharmacol
; 72(5): 563-72, 2016 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-26857125
4.
Absolute bioavailability of evacetrapib in healthy subjects determined by simultaneous administration of oral evacetrapib and intravenous [(13) C8 ]-evacetrapib as a tracer.
J Labelled Comp Radiopharm
; 59(6): 238-44, 2016 05 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-26639670
5.
CYP-mediated drug-drug interactions with evacetrapib, an investigational CETP inhibitor: in vitro prediction and clinical outcome.
Br J Clin Pharmacol
; 80(6): 1388-98, 2015 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-26264702
6.
Design and synthesis of new tetrahydroquinolines derivatives as CETP inhibitors.
Bioorg Med Chem Lett
; 22(11): 3671-5, 2012 Jun 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-22543028
7.
Design, synthesis and structure-activity-relationship of 1,5-tetrahydronaphthyridines as CETP inhibitors.
Bioorg Med Chem Lett
; 22(9): 3056-62, 2012 May 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-22497761
8.
Evacetrapib is a novel, potent, and selective inhibitor of cholesteryl ester transfer protein that elevates HDL cholesterol without inducing aldosterone or increasing blood pressure.
J Lipid Res
; 52(12): 2169-2176, 2011 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-21957197
9.
Fertility and Embryo-Fetal Development Assessment in Rats and Rabbits with Evacetrapib: A Cholesteryl Ester Transfer Protein Inhibitor.
Birth Defects Res
; 109(7): 513-527, 2017 04 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-28398618
10.
Prenatal and Postnatal Assessment in Rabbits with Evacetrapib: A Cholesteryl Ester Transfer Protein Inhibitor.
Birth Defects Res
; 109(7): 486-496, 2017 04 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-28398632
11.
Prediction of Transporter-Mediated Drug-Drug Interactions for Baricitinib.
Clin Transl Sci
; 10(6): 509-519, 2017 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-28749581
12.
Impact of Increased Gastric pH on the Pharmacokinetics of Evacetrapib in Healthy Subjects.
Pharmacotherapy
; 36(7): 749-56, 2016 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-27284735
13.
The Discovery, Preclinical, and Early Clinical Development of Potent and Selective GPR40 Agonists for the Treatment of Type 2 Diabetes Mellitus (LY2881835, LY2922083, and LY2922470).
J Med Chem
; 59(24): 10891-10916, 2016 12 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-27749056
14.
Evacetrapib: in vitro and clinical disposition, metabolism, excretion, and assessment of drug interaction potential with strong CYP3A and CYP2C8 inhibitors.
Pharmacol Res Perspect
; 3(5): e00179, 2015 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-26516590
15.
A Multidose Study to Examine the Effect of Food on Evacetrapib Exposure at Steady State.
J Cardiovasc Pharmacol Ther
; 20(5): 483-9, 2015 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-25736283
16.
Discovery of 6-(4-{[5-Cyclopropyl-3-(2,6-dichlorophenyl)isoxazol-4-yl]methoxy}piperidin-1-yl)-1-methyl-1H-indole-3-carboxylic Acid: A Novel FXR Agonist for the Treatment of Dyslipidemia.
J Med Chem
; 58(24): 9768-72, 2015 Dec 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-26568144
17.
Expression and activity of cytochromes P450 2E1, 2A, and 2B in the mouse ovary: the effect of 4-vinylcyclohexene and its diepoxide metabolite.
Toxicol Sci
; 73(2): 423-30, 2003 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-12700394
18.
Expression and activity of microsomal epoxide hydrolase in follicles isolated from mouse ovaries.
Toxicol Sci
; 68(1): 24-31, 2002 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-12075107
19.
Effects of the cholesteryl ester transfer protein inhibitor evacetrapib on lipoproteins, apolipoproteins and 24-h ambulatory blood pressure in healthy adults.
J Pharm Pharmacol
; 66(11): 1576-85, 2014 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-24961753
20.
Involvement of CYP 2E1 enzyme in ovotoxicity caused by 4-vinylcyclohexene and its metabolites.
Toxicol Appl Pharmacol
; 221(2): 215-21, 2007 Jun 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-17462685