Applying the resources and supports in self-management framework to examine ophthalmologist-patient communication and glaucoma medication adherence.

Little is known about how ophthalmologist-patient communication over time is associated with glaucoma patient long-term adherence. The purpose of our study was to examine the association between provider use of components of the resources and supports in self-management model when communicating with patients and adherence to glaucoma medications measured electronically over an 8-month period. In this longitudinal prospective cohort study, the main variables studied were ophthalmologist communication-individualized assessment, collaborative goal setting and skills enhancement. Patients with glaucoma who were newly prescribed or on glaucoma medications were recruited from six ophthalmology clinics. Patients' baseline and next follow-up visits were videotape-recorded. Patients were interviewed after their visits. Patients used medication event monitoring systems (MEMS) for 8 months after enrollment into the study, and adherence was measured electronically using MEMS for 240 days after their visits. Two hundred and seventy-nine patients participated. Patient race and regimen complexity were negatively associated with glaucoma medication adherence over an 8-month period. Provider communication behaviors, including providing education and positive reinforcement, can improve patient adherence to glaucoma medications over an 8-month period.

Alterations of white matter tracts following neurotoxic hippocampal lesions in macaque monkeys: a diffusion tensor imaging study.

Diffusion tensor imaging (DTI) is a valuable tool for assessing presumptive white matter alterations in human disease and animal models. The current study used DTI to examine the effects of selective neurotoxic lesions of the hippocampus on major white matter tracts and anatomically related brain regions in macaque monkeys. Two years postlesion, structural MRI, and DTI sequences were acquired for each subject. Volumetric assessment revealed a substantial reduction in the size of the hippocampus in experimental subjects, averaging 72% relative to controls, without apparent damage to adjacent regions. DTI images were processed to yield measures of fractional anisotropy (FA), apparent diffusion coefficient (ADC), parallel diffusivity (lADC), and perpendicular diffusivity (tADC), as well as directional color maps. To evaluate potential changes in major projection systems, a region of interest (ROI) analysis was conducted including the corpus callosum, fornix, temporal stem, cingulum bundle, ventromedial prefrontal white matter, and optic radiations. Lesion-related abnormalities in the integrity of the fiber tracts examined were limited to known hippocampal circuitry, including the fornix and ventromedial prefrontal white matter. These findings are consistent with the notion that hippocampal damage results in altered interactions with multiple memory-related brain regions, including portions of the prefrontal cortex.

Low back strengthening for the prevention and treatment of low back pain.

PURPOSE: Chronic low back pain (CLBP) remains one of the most difficult and costly medical problems in the industrialized world. A review of nineteenth and early twentieth century spine rehabilitation shows that back disorders were commonly treated with aggressive and specific progressive resistance exercise (PRE). Despite a lack of scientific evidence to support their efficacy, therapeutic approaches to back rehabilitation over the past 30 yr have focused primarily upon passive care for symptom relief. Recent spine rehabilitation programs have returned to active reconditioning PRE centered around low back strengthening to restore normal musculoskeletal function. Research has shown that lumbar extension exercise using PRE significantly increases strength and decreases pain in CLBP patients. It appears that isolated lumbar extension exercise with the pelvis stabilized using specialized equipment elicits the most favorable improvements in low back strength, muscle cross-sectional area, and vertebral bone mineral density (BMD). These improvements occur with a low training volume of 1 set of 8 to 15 repetitions performed to volitional fatigue one time per week. CLBP patients participating in isolated lumbar extension PRE programs demonstrate significant reductions in pain and symptoms associated with improved muscle strength, endurance, and joint mobility. Improvements occur independent of diagnosis, are long-lasting, and appear to result in less re-utilization of the health care system than other more passive treatments. Low back strengthening shows promise for the reduction of industrial back injuries and associated costs.

Constant vs variable resistance knee extension training.

To compare the effect of constant resistance (CR) and variable resistance (VR) training on full range-of-motion (ROM) strength development, 22 men and 27 women (age = 26 +/- 5 yr) were randomly assigned to either a CR training group (N = 17), a VR training group (N = 17), or a control group (N = 15) that did not train. The CR and VR groups trained 2 to 3 d.wk-1 for 10 wk. Subjects completed one set of full ROM (120 to 0 degrees of flexion) bilateral knee extensions with an amount of weight that allowed 8 to 12 repetitions during each training session. For the VR group, resistance was varied with a cam supplied by the manufacturer (Nautilus). For the CR group, the cam was removed and replaced with a round sprocket. Prior to and after training, maximal voluntary isometric torque was measured at 9, 20, 35, 50, 65, 80, 95, and 110 degrees of knee flexion. Analysis of covariance indicated that the VR and CR groups gained strength at all angles (P less than or equal to 0.05) when compared to the control. [table: see text] There was no difference (P greater than 0.05) between the CR and VR groups at any angle, and the magnitude of strength gained was similar (P greater than 0.05) among angles for both groups. These data indicate that both CR and VR knee extension training elicit full ROM strength development.

Limited range-of-motion lumbar extension strength training.

The purpose of this study was to evaluate the effect of limited range-of-motion (ROM) resistance training on the development of lumbar extension strength through a 72 degrees ROM. Thirty-three men and 25 women (age = 30 +/- 11 yr) were randomly assigned to one of three training groups or a control group (C; n = 10) that did not train. Training was conducted once per week for 12 wk and consisted of one set of 8-12 repetitions of variable resistance lumbar extensions until volitional fatigue. Group A (n = 18) trained from 72 degrees to 36 degrees of lumbar flexion; group B (n = 14) from 36 degrees to 0 degree of lumbar flexion; and group AB (n = 16) from 72 degrees to 0 degree of lumbar flexion. Prior to and after training, isometric lumbar extension torque was assessed at 72 degrees, 60 degrees, 48 degrees, 36 degrees, 24 degrees, 12 degrees, and 0 degree of lumbar flexion. Analysis of covariance showed that groups A, B, and AB increased lumbar extension torque (P less than or equal to 0.05) at all angles measured when compared with C. The greatest gains in torque were noted for groups A and B in their respective ranges of training but A and B did not differ from AB (P greater than 0.05) at any angle. These data indicate that limited ROM lumbar extension training through a 36 degrees ROM is effective for developing strength through 72 degrees of lumbar extension.

Effect of reduced frequency of training and detraining on lumbar extension strength.

To investigate the effect of reduced frequency of training and detraining on lumbar extension strength, 50 subjects (34 men, aged 34 +/- 11 yrs; and 16 women, aged 33 +/- 11 yrs) were recruited from ongoing strength training programs. Initial training consisted of 10 or 12 weeks of variable resistance lumbar extension strength exercise to volitional fatigue 1, 2, or 3 times a week. After the initial training, subjects reduced the frequency of training to once every 2 weeks (n = 18) or once every 4 weeks (n = 22) for 12 weeks. Only the frequency of training was changed; the mode, volume, and intensity of exercise remained constant for both reduced frequency of training groups. An additional ten subjects terminated training and acted as controls (detraining group). Isometric lumbar extension strength was evaluated at seven angles through a 72 degree range-of-motion before training, after training, and after reduced frequency of training or detraining. Analysis of variance with repeated measures indicated that lumbar extension strength improved (P < or = 0.05) for all groups after the initial 10 or 12 weeks of training. After 12 weeks of reduced training, the once every 2 weeks and once every 4 weeks groups showed no significant reduction in lumbar extension strength at any angle tested, whereas the detraining group demonstrated an average 55% reduction in strength. These findings indicate that isometric lumbar extension strength can be maintained for up to 12 weeks with a reduced frequency of training as low as once every 4 weeks when the intensity and the volume of exercise are maintained.

Effect of training frequency and specificity on isometric lumbar extension strength.

To investigate the effects of training frequency and specificity of training on isolated lumbar extension strength, 72 men (age = 31 +/- 9 years) and 42 women (age = 28 +/- 9 years) were tested before and after 12 weeks of training. Each test involved the measurement of maximum voluntary isometric torque at 72 degrees, 60 degrees, 48 degrees, 36 degrees, 24 degrees, 12 degrees, and 0 degrees of lumbar flexion. After the pretraining tests, subjects were randomly stratified to groups that trained with variable resistance dynamic exercise every other week (1X/2 weeks, n = 19), once per week (1X/week, n = 22), twice per week (2X/week, n = 23) or three times per week (3X/week, n = 21); a group that trained isometrically once per week (n = 14); or a control group that did not train (n = 15). Analysis of covariance showed that all training groups improved their ability to generate isometric torque at each angle measured when compared with controls (P less than 0.05). There was no statistical difference in adjusted posttraining isometric torques among the groups that trained (P greater than 0.05), but dynamic training weight increased to a lesser extent (P less than 0.08) for the 1X/2 weeks group (26.6%) than for the groups that trained 1X/week, 2X/week, and 3X/week (37.2 to 41.4%). These data indicate that a training frequency as low as 1X/week provides an effective training stimulus for the development of lumbar extension strength. Improvements in strength noted after isometric training suggest that isometric exercise provides an effective alternative for developing lumbar strength.

Quantitative assessment of full range-of-motion isometric lumbar extension strength.

The purpose of this study was to evaluate the reliability and variability of repeated measurements of isometric (IM) lumbar extension (LB EXT) strength made at different joint angles. Fifty-six men (age, 29.4 +/- 10.7 years) and 80 women (age, 24.3 +/- 9.1 years) completed IM LB EXT strength tests on 3 separate days (D1, D2, and D3). On D1 and D2, subjects completed two tests (T1 and T2) separated by a 20- to 30-minute rest interval. For each test, IM LB EXT strength was measured at 72, 60, 48, 36, 24, 12, and 0 degrees of lumbar extension. Mean IM strength values, within-day reliability coefficients, and test variability over the seven angles improved from D1 to D2 (D1: mean, 160.0 to 304.1 N.m, r = 0.78 to 0.96, SEE = 37.6 to 46.9 N.m; D2: mean, 176.3 to 329.1 N.m, r = 0.94 to 0.98, SEE = 29.0 to 34.4 N.m). Mean strength values leveled off by D3 (174.5 to 317.0 N.m). The most reliable test results showed that the IM LB EXT strength curves were linear and descending from flexion to extension and ranged from 235.8 +/- 85.2 to 464.9 +/- 150.7 N.m for men (extension to flexion) and from 134.6 +/- 53.2 to 237.3 +/- 71.9 N.m for women. Lumbar extension strength was clearly greatest in full flexion, which is in contrast to previously reported results. One practice test was required to attain the most accurate and reliable results. These data indicate that repeated measures of IM LB EXT strength are highly reliable and can be used for the quantification of IM LB EXT strength through a range of motion.

Quantitative assessment and training of isometric cervical extension strength.

The purpose of this study was to evaluate the reliability and variability of repeated measurements of isometric cervical extension strength and determine the effect of 10 weeks of dynamic variable resistance cervical extension training on isometric cervical extension strength. Seventy-three subjects (age, 29 +/- 12 years [mean +/- SD]) completed isometric cervical extension strength tests on 4 separate days (D1, D2, D3, and D4). For each test, isometric cervical strength was measured at 126 degrees, 108 degrees, 90 degrees, 72 degrees, 54 degrees, 36 degrees, 18 degrees, and 0 degrees of cervical flexion. Between-day correlation coefficients over the eight angles of cervical flexion were high for D2 versus D3 (r = 0.90 to 0.96). Test variability (standard error of estimate) between D2 versus D3 was low (7.4% to 10.2% of mean) through the entire range of motion. Regression analysis showed that the isometric cervical extension strength curve is linear and descending from flexion to extension. In a second study, 14 subjects (age, 25 +/- 3 years) trained the cervical extensor muscles for 10 weeks while 10 subjects (age, 23 +/- 3 years) served as controls. Training included 8 to 12 cervical extensions to volitional fatigue, 1 day per week. The training group improved isometric cervical extension strength at six of eight angles before to after training (P less than or equal to 0.05). During the same time period the control group did not change. These data indicate that repeated measures of isometric cervical extension strength are highly reliable and can be used for the quantification of isometric cervical extension strength through a 126 degrees range of motion.(ABSTRACT TRUNCATED AT 250 WORDS)

Effect of 12 and 20 weeks of resistance training on lumbar extension torque production.

This study compared the effect of varied training frequencies on the development of isometric lumbar extension torque (strength) over 12- and 20-week training periods. Fifty-six subjects were randomly assigned to training once every other week (training group 1, n = 10), once per week (training group 2, n = 12), twice per week (training group 3, n = 12), or three times per week (training group 4, n = 7) or to a nontraining control group (n = 15). Training consisted of one set of 8 to 12 variable-resistance lumbar extensions to volitional muscular fatigue. Prior to and following 12 and 20 weeks of training, subjects were given a test that evaluated isolated isometric lumbar extension torque in a seated position at seven positions (angles) through a 72-degree range of motion. The control group showed no change in isometric torque. All training groups showed significant increases in lumbar extension torque at 12 and 20 weeks of training, whereas no significant differences were found among the groups with respect to the magnitude of torque gained. Pooled training showed a significant time x angle interaction at 12 weeks and a continuing trend at 20 weeks, indicating that the shape of the isometric torque-angle curve changed as a result of training. This effect was due to greater increases in isometric torque at the fully extended position than at the fully flexed position at 12 weeks (92% versus 16%, respectively) and at 20 weeks (123% versus 17%, respectively).(ABSTRACT TRUNCATED AT 250 WORDS)

Comparison of Two Restraint Systems for Pelvic Stabilization during Isometric Lumbar Extension Strength Testing.

This study was supported in part by a grant from MedX Inc., Ocala, FL. Among strength testing methods, varying degrees of stabilization are used. The purpose of this study was to compare isometric lumbar extension strength values obtained from two different restraint systems designed to isolate the lumbar extensors through pelvic stabilization. Both restraint systems stabilized the pelvis by preventing movement of the lower extremities during testing with the subject in a seated position. One restraint system (KNEE) applied pressure just below the knees while the lower leg was positioned at 120 degrees of knee flexion. The other (FOOT) applied pressure to the bottom of the feet while the lower leg was positioned at 60 degrees of knee flexion. Fifteen men (age = 37 +/- 10 yr; height = 177.7 +/- 5.3 cm; weight = 61.4 +/- 10.9 kg) and six women (age = 43 +/- 7 yr; height = 170.9 +/- 7.9 cm; weight = 61.4 +/- 10.9 kg) were tested at seven positions through 72 degrees range of motion with each restraint system. Analysis of variance for repeated measures indicated a significant difference (p 0.05) between restraints were noted at 24, 12, or 0 degrees flexion. Thus, the restraint system employed can influence lumbar extension strength values and affect the shape of the isometric lumbar extension strength curve. J Orthop Sports Phys Ther 1992;15(1):37-42.

Early Start: an obstetric clinic-based, perinatal substance abuse intervention program.

Maternal substance abuse is a serious problem with significant adverse effects to mothers, fetuses, and children. The Early Start Program provides pregnant women in a managed care organization with screening and early identification of substance abuse problems, early intervention, ongoing counseling, and case management by a licensed clinical social worker located in the prenatal clinic, where she is an integral part of the prenatal team. We describe the development of the Early Start Program, its administrative history, and how it has interfaced with clinicians and administrators. We also highlight two important program characteristics: the partnership with a perinatal health services research unit and the degree to which the program could be "exported" to other managed care settings.

Expression of vascular endothelial growth factor in canine oral malignant melanoma.

Serum, plasma and tissue expression of vascular endothelial growth factor (VEGF) was measured in 20 dogs previously diagnosed histologically with oral melanoma. The concentrations of VEGF in serum and plasma were significantly higher in dogs with melanoma than in a control population (P

Effect of reduced training frequency on muscular strength.

Twenty-four men and 26 women (25 +/- 5 years) participating in 10 weeks (n = 27) and 18 weeks (n = 23) of variable resistance strength training programs were recruited to complete 12 weeks of reduced training. Training consisted of one set of 7-10 bilateral knee extensions performed to volitional failure. Prior to the reduced training phase of the project, the subjects were training either 2 days.week-1 (n = 23) or 3 days.week-1 (n = 18). The subjects who trained 3 days.week-1 reduced training frequency to 2 days.week-1 (n = 9), 1 day.week-1 (n = 7), or 0 days.week-1 (n = 2). The subjects who trained 2 days.week-1 reduced training frequency to 1 day.week-1 (n = 12) or 0 days.week-1 (n = 11). Nine subjects served as controls and did not train. Isometric knee extension strength was assessed at 9, 20, 35, 50, 65, 80, 95, and 110 degrees of knee flexion on two separate occasions prior to and immediately post-training and following reduced training. After training, mean relative increases in peak isometric knee extension strength and dynamic training weight were 21.4% +/- 17.5% (P less than or equal to 0.01) and 49.5% +/- 14.7% (P less than or equal to 0.01), respectively. The subjects who stopped training (0 days.week-1) lost 68% (P less than or equal to 0.01) of the isometric strength gained during training.(ABSTRACT TRUNCATED AT 250 WORDS)

Comparison of 2 vs 3 days/week of variable resistance training during 10- and 18-week programs.

The purpose of this study was to evaluate the effectiveness of resistance training performed either 2 days/week or 3 days/week. One hundred and seventeen sedentary volunteers were randomly assigned to one of the two training groups or a control group. Twenty-two men (27 +/- 5 years) and 22 women (26 +/- 5 years) trained for 10 weeks. Twenty-five men (26 +/- 5 years) and 22 women (24 +/- 5 years) trained for 18 weeks. Twenty-six subjects served as controls and did not train. Training consisted of a single set of variable resistance bilateral knee extensions performed to volitional fatigue with a weight load that allowed seven to ten repetitions. Prior to and immediately following training, isometric strength was evaluated at 70, 85, 100, 115, 130, 145, 160, and 171 degrees of knee extension with a Nautilus knee extension tensiometer. All groups who trained showed a significant increase in peak isometric strength when compared with controls (P less than 0.01). Groups that trained 3 days/week increased peak isometric strength (10 weeks = 21.2%; 18 weeks = 28.4%) to a greater extent (P less than 0.05) than groups that trained 2 days/week (10 weeks = 13.5%; 18 weeks = 20.9%). We conclude that resistance training 2 days/week significantly improves knee extension isometric strength; however, the magnitude of strength gain is greater when training is performed 3 days/week. These data indicate that the adult exerciser (18 to 38 years) training 2 days/week may derive approximately 80% of the isometric strength benefits achieved by those training 3 days/week.

Rehospitalization in the first two weeks after discharge from the neonatal intensive care unit.

BACKGROUND: High-risk newborns are known to have higher than average utilization of services after discharge from the neonatal intensive care unit (NICU). Most studies on this subject report aggregate data over periods ranging from 1 to 3 years postdischarge. Little is known about events that are temporally close to NICU discharge. OBJECTIVES: To characterize rehospitalizations within the first 2 weeks after discharge from six community NICUs. METHODS: We scanned electronic databases and reviewed the charts of rehospitalized infants from six NICUs in the Kaiser Permanente Medical Care Program. We subdivided infants into five groups based on gestational age (GA) and birth hospitalization length of stay (LOS): 1) >/=37 weeks' GA with <4 days LOS (n = 2593); 2) >/=37 weeks' GA with >/=4 days' LOS (n = 1133); 3) from 33 to 36 weeks' GA with <4 days' LOS (n = 545); 4) from 33 to 36 weeks' GA with >/=4 days' LOS (n = 1196); and 5) <33 weeks' GA (n = 587). We performed bivariate and multivariate analyses to identify predictors that might be useful for practitioners. RESULTS: There were 6054 newborns discharged alive from the six study NICUs between August 1, 1992 and December 31, 1995, and 99.5% of these infants remained in the health plan during the 2 weeks after NICU discharge. The overall rehospitalization rate was 2.72%, which is 20% higher than the rate among healthy term newborns in the Kaiser Permanente Medical Care Program (2.26%). The two most common reasons for rehospitalization were jaundice (62/165, 37.6%) and feeding difficulties (25/165, 15.2%). Infants with 33 to 36 weeks' GA and <4 days' LOS were rehospitalized at a significantly higher rate than were all other infants (5.69%); 71% of infants in this group were rehospitalized for jaundice. The following variables predicted rehospitalization in multivariate models: <33 weeks' GA (adjusted OR [AOR]: 1.88; 95% CI: 1.10-3.21), from 33 to 36 weeks' GA with <96 hours' LOS (AOR: 2.94; 95% CI: 1.87-4.62), and birth at facility B, which had the highest rehospitalization rate of the six facilities (AOR: 1.92; 95% CI: 1.39-2.65). CONCLUSIONS: The rate of rehospitalization among NICU graduates is higher than among healthy term infants. Most of the rehospitalizations among infants with from 33 to 36 weeks' GA and <4 days' LOS are for illnesses that are not life-threatening. Collaborative studies and new process and outcomes measures are needed to assess the effectiveness of follow-up strategies in high-risk newborns.

Can spinal surgery be prevented by aggressive strengthening exercises? A prospective study of cervical and lumbar patients.

OBJECTIVE: To determine if patients recommended for spinal surgery can avoid the surgery through an aggressive strengthening program. SETTING: A privately owned clinic, staffed by physicians and physical therapists, that provides treatment for patients with neck and/or back pain. METHODS: Over a period of 2 1/2 years, consecutive patients referred to the clinic for evaluation and treatment were enrolled in the study if they (1) had a physician's recommendation for lumbar or cervical surgery, (2) had no medical condition preventing exercise, and (3) were willing to participate in the approximately 10-week outpatient program. Treatment consisted mainly of intensive, progressive resistance exercise of the isolated lumbar or cervical spine. Exercise was continued to failure, and patients were encouraged to work through their pain. Third-party payors in Minneapolis were surveyed for average costs. Average follow-up occurred 16 months after discharge. RESULTS: Forty-six of the 60 participants completed the program; 38 were available for follow-up and three required surgery after completing the program. DISCUSSION/CONCLUSIONS: Despite methodologic limitations, the results are intriguing. A large number of patients who had been told they needed surgery were able to avoid surgery in the short term by aggressive strengthening exercise. This study suggests the need to define precisely what constitutes "adequate conservative care."

Pelvic stabilization during resistance training: its effect on the development of lumbar extension strength.

The purpose of this study was to evaluate and compare resistance exercise training with and without pelvic stabilization on the development of isolated lumbar extension strength. Isometric torque of the isolated lumbar extensor muscles was measured at seven positions through a 72 degree range-of-motion on 47 men and 30 women before and after 12 weeks of variable resistance lumbar extension training. Subjects were assigned to either a group that trained with pelvic stabilization (P-STAB, n = 21), a group that trained without pelvic stabilization (NO-STAB, n = 41), or a control group that did not train (n = 15). Subjects trained once a week with 8 to 12 repetitions to volitional exhaustion. The P-STAB and NO-STAB groups showed significant (p < or = 0.05) and similar increases in the weight load used for training (P-STAB = 24.1 +/- 9.4kg; NO-STAB = 19.4 +/- 11.0kg) during the 12-week training period. In contrast, posttraining isometric torque values describing isolated lumbar extension strength improved only for the P-STAB group (23.5%, p < or = 0.05) and not for the NO-STAB group (-1.2%, p > 0.05) relative to controls. These data indicate that pelvic stabilization is required to effectively train the lumbar extensor muscles. The increased training load for the NO-STAB group is probably the result of exercising the muscles involved in pelvic rotation (hamstring and buttock muscles).