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1.
Am J Clin Nutr ; 60(4): 510-7, 1994 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-8092085

RESUMO

To investigate the relationships between aging and selenium status, vitamins A and E, and plasma and erythrocyte fatty acids, we studied 105 healthy subjects (53 women, 52 men) living in Nove, a village near Vicenza (Veneto Region, northern Italy). The subjects were distributed equally for age and sex into four groups: group 1, 20-39 y; group 2, 40-59 y; group 3, 60-75 y; and group 4, > 75 y. A careful selection of subjects to exclude those with chronic or acute diseases was obtained with the collaboration of the three general practitioners operating in Nove. Aging was associated with a progressive decrease in selenium status and in the ratio of plasma and erythrocyte polyunsaturated to saturated fatty acids (P:S). Stepwise multiple linear analysis revealed age, vitamin A, and n-6 polyunsaturated fatty acids (PUFAs) as useful predictors of a substantial proportion of the selenium variability (R = 0.618, R2 = 0.382; P < 0.001) and age and erythrocyte oleic acid as predictors of erythrocyte glutathione peroxidase variability (R = 0.413, R2 = 0.17; P < 0.001).


Assuntos
Envelhecimento/sangue , Ácidos Graxos/sangue , Estado Nutricional , Selênio/sangue , Vitamina A/sangue , Vitamina E/sangue , Adulto , Idoso , Idoso de 80 Anos ou mais , Eritrócitos/metabolismo , Ácidos Graxos Insaturados , Feminino , Glutationa Peroxidase/sangue , Humanos , Itália , Masculino , Malondialdeído/sangue , Pessoa de Meia-Idade , Análise de Regressão , Superóxido Dismutase/sangue
2.
J Interferon Cytokine Res ; 16(8): 585-8, 1996 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-8877728

RESUMO

We investigated the prevalence of mixed cryoglobulinemia (MC) in 100 cases of chronic hepatitis C virus (HCV) infection and the effect of a 6-month treatment with interferon-alpha (IFN-alpha). Cryoglobulins were detected on admission in 36 of 100 patients and appeared during observation in a further 18 cases. Cryocrit ranged from 0.5% to 20%. Patients with MC were older and had a higher incidence of cirrhosis than those without MC. Immunologic characterization of the cryoprecipitate showed the presence of type II in 84% of cases and type III in 16%. The patients received IFN-alpha (6 MU three times per week) for 6 months. Fifty-seven were responders (i.e., reached normal aminotransferase levels), 26 of these relapsed within 2 months after IFN withdrawal, and 30 did not relapse. After IFN-alpha treatment, cryoglobulinemia disappeared in 11 of the 21 evaluable responders, but in none of the 15 nonresponder patients (p < 0.003). The clearance of MC was associated in all cases with clearance of HCV RNA. The delayed appearance of cryoglobulinemia in responders seems to be associated with a higher probability of relapse.


Assuntos
Adjuvantes Imunológicos/uso terapêutico , Crioglobulinemia/etiologia , Hepatite C/complicações , Hepatite Crônica/complicações , Interferon-alfa/uso terapêutico , Adolescente , Adulto , Idoso , Crioglobulinemia/epidemiologia , Crioglobulinemia/terapia , Crioglobulinas/análise , Feminino , Hepatite C/sangue , Hepatite C/terapia , Hepatite Crônica/sangue , Hepatite Crônica/terapia , Humanos , Interferon alfa-2 , Masculino , Pessoa de Meia-Idade , Prevalência , Proteínas Recombinantes
3.
Clin Biochem ; 20(6): 415-7, 1987 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-2830048

RESUMO

Liver catalase activity, one of the free-radical scavenger enzymes, has been measured in 22 normal subjects and compared with that of 13 patients suffering from hepatocellular carcinoma. The activity was estimated both in tumor tissue and in tumor-free tissue. A significant reduction of catalase activity was noted in tumor tissue (p less than 0.001) as well as in the adjacent tumor-free tissue (p less than 0.02). In patients with hepatoma, the serum iron level was lower than in normal (p less than 0.01) and was correlated with enzyme activity (r = 0.958). These findings suggest that in hepatocarcinoma the free radical scavenger system is impaired.


Assuntos
Carcinoma Hepatocelular/enzimologia , Catalase/metabolismo , Neoplasias Hepáticas/enzimologia , Fígado/enzimologia , Adulto , Idoso , Carcinoma Hepatocelular/complicações , Catalase/sangue , Feminino , Humanos , Ferro/sangue , Cirrose Hepática/complicações , Cirrose Hepática/enzimologia , Neoplasias Hepáticas/complicações , Masculino , Pessoa de Meia-Idade
4.
Clin Chim Acta ; 252(2): 171-80, 1996 Aug 30.
Artigo em Inglês | MEDLINE | ID: mdl-8853564

RESUMO

Laminin is a major basement membrane-associated, non-collagenous glycoprotein of the extracellular matrix and is deposited in the space of Disse during sinusoidal capillarisation. Laminin P1, a pepsin-resistant fragment originating from the central portion of the cross-shaped laminin molecule, is detectable in serum and has been related to liver fibrosis and portal hypertension. In this study we investigated the behaviour of serum laminin P1, measured by radioimmunoassay, in a homogeneous group of 95 patients suffering from chronic viral hepatitis, types C or B, in order to determine the relationships between serum laminin P1 and each of the main histological aspects of the disease process (i.e. portal-periportal activity, lobular activity and fibrosis), which were assigned numerical scores. Moreover, we computed, at several cut-off levels, the sensitivity, specificity and positive and negative predictive values of laminin P1 in detecting both necroinflammatory activity and fibrosis in the liver. The results show that serum laminin P1 levels parallel the severity of liver disease, the highest laminin concentrations being observed in cirrhotic patients. They suggest also that serum laminin P1 should be considered a marker of the liver disease process as a whole, rather than a marker exclusively linked to fibrosis. Nevertheless, the usefulness of serum laminin P1 measurement, as investigated in this study, seems too limited to be recommended for routine clinical practice.


Assuntos
Hepatite Viral Humana/sangue , Laminina/sangue , Fragmentos de Peptídeos/sangue , Adolescente , Adulto , Idoso , Feminino , Hepatite Viral Humana/diagnóstico , Hepatite Viral Humana/patologia , Humanos , Masculino , Pessoa de Meia-Idade , Valor Preditivo dos Testes , Sensibilidade e Especificidade
5.
Clin Chim Acta ; 270(2): 139-50, 1998 Feb 23.
Artigo em Inglês | MEDLINE | ID: mdl-9544451

RESUMO

Erythrocyte-membrane fatty acid composition and cholesterol content were evaluated along with serum selenium in 33 patients with liver cirrhosis and in 40 normal subjects. Thirteen patients were suffering from post-viral (group V) and 20 from alcoholic (group A) cirrhosis. The aim of the study was to elucidate whether membrane lipid abnormalities in cirrhosis were linked to the aetiology of the disease or whether they were the results of the cirrhotic process itself. The patients presented a significant increase in membrane cholesterol, palmitic acid (C16:0) and saturated fatty acids (SFA), and a decrease in polyunsaturated fatty acids (PUFA) and polyunsaturated/saturated fatty acids ratio (P/S) compared with the control group. Serum selenium levels were significantly reduced. When patients were subdivided according to aetiology, the alcoholic patients showed greater lipid composition abnormalities than the viral cirrhotics (higher levels of SFA and lower PUFA and P/S), while pathologic palmitic acid, membrane cholesterol and serum selenium values were confirmed in both groups of patients. In conclusion, low serum selenium and a series of erythrocytes membrane lipid composition abnormalities would appear to be features peculiar to cirrhosis. Alcoholic cirrhotics, on the other hand, show a more deranged erythrocyte membrane lipid profile.


Assuntos
Membrana Eritrocítica/metabolismo , Cirrose Hepática Alcoólica/sangue , Cirrose Hepática/sangue , Cirrose Hepática/virologia , Lipídeos de Membrana/sangue , Selênio/sangue , Adulto , Idoso , Ácidos Graxos/sangue , Ácidos Graxos Ômega-3/sangue , Ácidos Graxos Ômega-6 , Ácidos Graxos Insaturados/sangue , Feminino , Hepatite C , Humanos , Masculino , Pessoa de Meia-Idade
6.
Clin Chim Acta ; 160(3): 289-96, 1986 Nov 15.
Artigo em Inglês | MEDLINE | ID: mdl-3539410

RESUMO

Plasma fibronectin (FN) has been measured by immunonephelometric method in 100 cirrhotic patients and compared with that of 77 normal subjects and with that of 57 patients suffering from liver disorders different from cirrhosis. Both, compensated and decompensated cirrhotics had lower plasma FN than controls (31.14 +/- 11.42 and 20.88 +/- 10.43 respectively vs 40.13 +/- 8.58 mg/dl; rho less than 0.02 and rho less than 0.001). FN in ascitic patients was lower than in non-ascitic (rho less than 0.001). These differences were not due to different weight or age of patients. It appears, therefore, that FN parallels in cirrhosis the grade of liver function impairment. No significant difference has been noted between plasma FN of patients with liver diseases different from cirrhosis and control subjects. In cirrhosis, a positive relation has been observed among FN and other parameters of liver function such as serum albumin, cholinesterase activity, fibrinogen and prothrombin time. Plasma FN has a low sensitivity but a high specificity and a good positive predictive value in distinguishing normals and patients with liver disorders different from cirrhosis. This diagnostic value is similar to that of serum albumin.


Assuntos
Fibronectinas/sangue , Cirrose Hepática/sangue , Adulto , Fatores Etários , Idoso , Peso Corporal , Diagnóstico Diferencial , Feminino , Humanos , Técnicas Imunológicas , Cirrose Hepática/diagnóstico , Hepatopatias/diagnóstico , Masculino , Pessoa de Meia-Idade , Nefelometria e Turbidimetria , Testes Sorológicos , Albumina Sérica/análise
7.
Clin Chim Acta ; 179(3): 315-22, 1989 Feb 22.
Artigo em Inglês | MEDLINE | ID: mdl-2714004

RESUMO

In order to clarify the significance of procollagen III peptide (PIIIP) and fibronectin (FN) blood concentration in alcohol related chronic liver disease (ALD), we have investigated their relationships with histological liver features and biochemical liver tests in 44 ALD patients. PIIIP was measured in serum by radioimmunoassay whereas FN was determined in plasma using an immunonephelometric method. In each liver biopsy, steatosis, portal infiltrate, lobular necro-inflammation, portal fibrosis and lobular fibrosis were semiquantitatively assessed by scoring from 0 to 3. A close correlation of PIIIP was found with morphological features of fibrosis (both of lobular and portal type), but not with necro-inflammation or steatosis. PIIIP was also positively correlated with ALP and GGT and exhibited a good diagnostic value in liver fibrosis. On the contrary, FN did not distinguish between normals and patients and was not correlated with any morphological liver feature or biochemical liver test. We also conclude that serum NP3P effectively reflects liver fibrosis, whereas plasma FN seems not related to any of the main histological aspects of liver damage in ALD.


Assuntos
Fibronectinas/sangue , Hepatopatias Alcoólicas/sangue , Fígado/patologia , Fragmentos de Peptídeos/sangue , Pró-Colágeno/sangue , Adulto , Idoso , Feminino , Humanos , Fígado/metabolismo , Hepatopatias Alcoólicas/metabolismo , Hepatopatias Alcoólicas/patologia , Testes de Função Hepática , Masculino , Pessoa de Meia-Idade , Valor Preditivo dos Testes
8.
Clin Chim Acta ; 182(2): 221-7, 1989 Jun 30.
Artigo em Inglês | MEDLINE | ID: mdl-2776352

RESUMO

In 55 patients with alcoholic cirrhosis and in 47 healthy individuals we assayed the concentration of selenium in serum (S-Se) by proton induced X-ray emission, the aminoterminal peptide of type III procollagen (NPIIIP) by RIA and the plasma fibronectin (FN) by immuno-nephelometry, together with routine biochemical tests. S-Se was lower in cirrhosis than in controls (0.57, SD 0.20 vs 0.92, SD 0.16 mumol/l; p less than 0.001) and was more reduced in ascitic than in compensated patients (0.50, SD 0.19 vs 0.66, SD 0.17 mumol/l; p less than 0.001). Regression analysis showed a positive correlation of S-Se with serum albumin and FN, whereas necrotic or inflammatory activity seems unrelated to S-Se; a negative correlation was found between S-Se and NPIIIP, suggesting a protective role of selenium against fibrosis.


Assuntos
Cirrose Hepática Alcoólica/sangue , Selênio/sangue , Adulto , Idoso , Biomarcadores/sangue , Feminino , Fibrose , Humanos , Fígado/patologia , Fígado/fisiopatologia , Masculino , Pessoa de Meia-Idade
9.
Clin Chim Acta ; 265(1): 21-31, 1997 Sep 08.
Artigo em Inglês | MEDLINE | ID: mdl-9352126

RESUMO

Laminin P1 (pepsin-resistant fragment of laminin) and aminoterminal peptide of type III procollagen are measurable in serum and are now considered useful serum markers of fibrogenesis and inflammation in chronic liver diseases. However, very few studies thus far have focused on assessing the diagnostic value of these markers in detecting fibrosis and necro-inflammatory activity in chronically diseased liver. The aim of the present study was therefore to investigate the correlations of laminin and type III procollagen with liver histology and to compare their diagnostic value in detecting the degree of liver fibrosis and necro-inflammatory activity in a homogeneous group of 99 patients suffering from chronic hepatitis C, and lacking other factors which can directly affect the serum levels of the two markers. Both these serum markers were measured by radioimmunoassay, employing commercially available kits. The three main aspects of liver pathology, i.e. portal-periportal activity, lobular activity and fibrosis, were histologically evaluated and semiquantitatively expressed by numerical scores. The results of this study show that laminin and type III procollagen were both positively correlated with the histological scores for portal-periportal activity and with those for fibrosis, whereas no significant correlation was observed between each of the two serum markers and the histological scores for lobular activity. The sensitivity and specificity of laminin and type III procollagen in detecting histological aspects of fibrosis and disease activity in liver, computed at various cut-off levels, showed overlapping trends for the two markers; however, the diagnostic value was in general rather low, whatever the cut-off considered. We therefore conclude that the 'static' measurement of both serum laminin and type III procollagen is of limited value for individual diagnosis of liver damage.


Assuntos
Hepatite C Crônica/sangue , Hepatite C Crônica/diagnóstico , Laminina/sangue , Cirrose Hepática/sangue , Cirrose Hepática/diagnóstico , Fragmentos de Peptídeos/sangue , Pró-Colágeno/sangue , Adolescente , Adulto , Idoso , Feminino , Hepatite C Crônica/patologia , Humanos , Cirrose Hepática/patologia , Masculino , Pessoa de Meia-Idade , Valor Preditivo dos Testes , Sensibilidade e Especificidade
10.
Clin Rheumatol ; 16(4): 409-12, 1997 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-9259257

RESUMO

Liver involvement in patients with primary Sjögren's syndrome is rare, usually without clinical significance and histologically characterized by a feature like stage 1 primary biliary cirrhosis. We describe herein a case of acute and severe autoimmune hepatitis in a patient suffering from primary Sjögren's syndrome. The diagnosis of Sjögren's syndrome was performed in 1989. In June 1995 the patient presented severe weakness, jaundice and elevation of transaminases; moreover IgG raised to 5560 mg/dl and ANA titre increased to 1:20480. The patient denied alcohol and drug use and a viral hepatitis was excluded. Antimitochondrial antibodies, anti-smooth muscle antibodies and antibodies against liver kidney microsomes were negative. An abdomen ultrasound examination revealed hepatomegaly, with irregular echogenic structure and lymphoadenomegaly near the celiac tripod. Liver biopsy demonstrated a picture of autoimmune hepatitis. The patient was treated with prednisone 50 mg/day and azathioprine 50 mg/day, with improvement in clinical and liver function indices. At present, the patient is given only 10 mg/day of prednisone. The association of Sjögren's syndrome with autoimmune hepatitis is very rare: in the literature only one other similar case has been reported.


Assuntos
Doenças Autoimunes/complicações , Hepatite/complicações , Síndrome de Sjogren/complicações , Feminino , Humanos , Pessoa de Meia-Idade , Síndrome de Sjogren/diagnóstico
11.
Hepatogastroenterology ; 47(31): 220-5, 2000.
Artigo em Inglês | MEDLINE | ID: mdl-10690612

RESUMO

BACKGROUND/AIMS: In chronic viral hepatitis, an enhanced iron load is related to lower response to interferon. Furthermore, iron, through the production of oxygen radicals, may stimulate hepatocyte necrosis and the activation of cells responsible for synthesis and deposition of extracellular matrix. We investigated the relationship between iron load, evaluated by serum assays, and liver fibrogenesis in chronic active viral hepatitis. METHODOLOGY: Serum iron, ferritin, transferrin saturation and serum markers of hepatic fibrogenesis (Laminin and the amino-terminal peptide of procollagen III-NPIIIP-) were assayed in 102 patients (47 females, 55 males, mean age 42.48 years) affected by chronic hepatitis C virus and in 81 healthy controls (47 males, 34 females). In hepatitis C virus patients (studied before alpha-interferon treatment) a semiquantitative score for portal inflammation, necrosis and fibrosis was applied to liver biopsy. RESULTS: Serum indices of iron load were higher in hepatitis C virus patients than in controls, and were higher in cirrhotic than in chronic hepatitis cases. Ferritin and serum iron were positively correlated with NPIIIP and laminin; moreover cases with ferritin levels over the normal limit for sex and age had higher levels of NPIIIP and laminin than cases with normal or poor iron status. CONCLUSIONS: Our data suggest that even a mild increase of iron load stimulates hepatic fibrogenesis, probably adding oxygen free radical injury to the damage of viral infection.


Assuntos
Ferritinas/metabolismo , Hepatite C Crônica/metabolismo , Ferro/metabolismo , Cirrose Hepática/metabolismo , Adulto , Idoso , Antivirais/uso terapêutico , Distribuição de Qui-Quadrado , Feminino , Ferritinas/sangue , Hepatite C Crônica/tratamento farmacológico , Humanos , Interferon alfa-2 , Interferon-alfa/uso terapêutico , Ferro/sangue , Laminina/metabolismo , Modelos Lineares , Cirrose Hepática/etiologia , Masculino , Pessoa de Meia-Idade , Pró-Colágeno N-Endopeptidase/metabolismo , Proteínas Recombinantes , Estatísticas não Paramétricas , Transferrina/metabolismo
12.
Hepatogastroenterology ; 28(4): 195-8, 1981 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-7024075

RESUMO

Liver plasma membranes (LPM) prepared from normal hepatocytes by centrifugation in sucrose discontinuous gradient, are capable of haemolysing PNH-like cells in the presence of complement or complement plus EGTA or MG2+ ions. In contrast, EDTA or Ca2+ ions inhibit the lysis. The total complement lytic activity is reduced by some 40% when fresh serum is incubated with LPM, whereas the total amount of C4 remains constant. The cross-immunoelectrophoresis studies of fresh serum incubated with LPM demonstrate the appearance of C3 breakdown products, which suggests the activation of the alternative complement pathway. In contrast, the sucrose test, which proceeds mainly through the classical complement pathway, is inhibited by LPM. The possible role of complement in liver disease is discussed.


Assuntos
Membrana Celular/imunologia , Ativação do Complemento , Via Alternativa do Complemento , Fígado/citologia , Centrifugação com Gradiente de Concentração , Complemento C4/análise , Humanos , Imunoeletroforese Bidimensional , Técnicas Imunológicas , Hepatopatias/imunologia , Sacarose
13.
Tumori ; 72(6): 617-9, 1986 Dec 31.
Artigo em Inglês | MEDLINE | ID: mdl-3027933

RESUMO

Twelve adults with hepatocellular carcinoma (HCC) and 8 individuals with histologically normal liver, were measured for serum selenium concentration and glutathione peroxidase (GSH-Px) of liver tissue. It was found a reduced serum selenium and liver GSH-Px in patients with HCC. Serum selenium concentration and the enzyme activity were positively correlated (p less than 0.01). The increased risk of carcinoma in selenium deficiency may be partially due to a reduced activity of GSH-Px, one of the most important scavenger enzymes of oxygen toxic radicals.


Assuntos
Carcinoma Hepatocelular/metabolismo , Glutationa Peroxidase/análise , Neoplasias Hepáticas/metabolismo , Fígado/enzimologia , Selênio/sangue , Feminino , Humanos , Masculino
14.
Tumori ; 75(5): 498-502, 1989 Oct 31.
Artigo em Inglês | MEDLINE | ID: mdl-2557694

RESUMO

To evaluate the prognostic value of serum copper (S-Cu) and ceruloplasmin and their pathophysiologic significance in human hepatocellular carcinoma (HCC), we studied 49 patients with HCC (20 of which were submitted to partial hepatectomy) compared with 110 patients with liver cirrhosis. In HCC both S-Cu and ceruloplasmin were higher than in cirrhosis; moreover, S-Cu was correlated with the extension of HCC, evaluated by instrumental data and by surgical inspection. In cirrhotic patients, mean S-Cu was 122.9 micrograms/dl (SD, 29.3), in early HCC, 153.0 micrograms/dl (SD, 34.5), and in advanced HCC, 193.1 micrograms/dl (SD, 37.7). Variance analysis gave F = 59.4. In HCC patients S-Cu was positively correlated with ceruloplasmin and with fibrinogen. Survival, evaluated by Mantel's test stratified for surgical therapy, was longer in patients with S-Cu levels lower than 175 micrograms/dl and in those at an earlier stage. We therefore conclude that S-Cu has a relevant diagnostic value in detecting HCC also in early stage and allows prognostic evaluation as regards survival.


Assuntos
Biomarcadores Tumorais/sangue , Carcinoma Hepatocelular/diagnóstico , Ceruloplasmina/análise , Cobre/sangue , Neoplasias Hepáticas/diagnóstico , Adolescente , Adulto , Idoso , Carcinoma Hepatocelular/sangue , Carcinoma Hepatocelular/cirurgia , Diagnóstico Diferencial , Feminino , Hepatectomia , Humanos , Cirrose Hepática/diagnóstico , Neoplasias Hepáticas/sangue , Neoplasias Hepáticas/cirurgia , Masculino , Pessoa de Meia-Idade , Prognóstico
15.
Minerva Med ; 73(34): 2183-8, 1982 Sep 08.
Artigo em Italiano | MEDLINE | ID: mdl-7110600

RESUMO

Clinical history and morbid anatomy findings of a new case of ataxia-telangiectasia are reported. A 26 years old man, with overt signs of the disease since the age of 8, died for decompensated cirrhosis; in the last year he suffered for cerebral haemorrhage; post-mortem examination showed venous angiectasias in cerebral white matter that caused two macroscopical areas of haemorrhagic infarction and multiple pin-pointed haemorrhages. We suggest that longer survival of patients with A.T., due to better management of infectious complications, permits the appearance of vascular abnormality not only in skin and mucosae, but also in deep organs, generally protected from environmental damages.


Assuntos
Ataxia Telangiectasia/complicações , Hemorragia Cerebral/etiologia , Cirrose Hepática/complicações , Adulto , Encéfalo/patologia , Hemorragia Cerebral/patologia , Antígenos de Superfície da Hepatite B/imunologia , Humanos , Cirrose Hepática/imunologia , Cirrose Hepática/patologia , Masculino
16.
Ann Ital Med Int ; 15(3): 226-31, 2000.
Artigo em Italiano | MEDLINE | ID: mdl-11059065

RESUMO

Inflammatory pseudotumor is a rare disease, that is regarded as a benign reactive inflammatory process, although its etiology and pathogenesis are still unknown. The liver is one of the organs most frequently involved, but inflammatory pseudotumors have been reported in many other sites in the body. Inflammatory pseudotumor of the liver presents as a solitary or, less frequently, multiple space-occupying lesion, which the common imaging techniques do not clearly distinguish from primitive or metastatic hepatic malignancies. Biopsy of the lesion is therefore necessary for diagnosis. The case of inflammatory pseudotumor described here presented with radiologic features of multiple solid space-occupying lesions in the liver, associated with multiple osteolytic lesions in the ribs. Such an association, very suggestive of malignancy, has not yet been reported for inflammatory pseudotumors. Optimum management of this disease has not yet been standardized. The majority of patients are treated by hepatic resection, although spontaneous regression has also been described. In our case, rapid improvement of both hepatic and costal lesions was observed, although the patient did not receive any specific treatment.


Assuntos
Granuloma de Células Plasmáticas , Hepatopatias , Osteólise Essencial , Costelas , Idoso , Biópsia , Feminino , Seguimentos , Granuloma de Células Plasmáticas/complicações , Granuloma de Células Plasmáticas/diagnóstico , Humanos , Fígado/patologia , Hepatopatias/complicações , Hepatopatias/diagnóstico , Osteólise Essencial/complicações , Osteólise Essencial/diagnóstico , Radiografia Torácica , Fatores de Tempo , Tomografia Computadorizada por Raios X
17.
Presse Med ; 25(4): 157-8, 1996 Feb 03.
Artigo em Francês | MEDLINE | ID: mdl-8728901

RESUMO

Chyluria is the passage of chylus into urine resulting in fistulization through the lymphatic system and the urinary system. This rare condition is usually caused by filaria infestation or malformations, neoplasia or trauma. We report a case of a 18-year-old man. The patient presented milky urine which had appeared after angiography following minor leg trauma. Physical examination revealed asymmetry of the face and cutaneous dyschromia. Blood tests revealed hypogammaglobulinemia and altered CD4/CD8 ratio (0.6). Urine tests showed proteinuria (30 mg/dl), lipiduria (triglycerides 750 mg/dl) and density of 1025. Renal function was normal. Abdomen computed tomography and urography were normal. Cystoscopy revealed the presence of milky urine in the bladder and selective catheterization revealed that the origin was the right ureter alone. Ascendent pyelography did not reveal any malformation of the urinary tract; but after this the chyluria spontaneously disappeared. The patient was rehospitalized 3 months later for recurrence. Lymphography was then performed and revealed a dilated lymphatic network with minute lacunar images projecting into the right kidney. Chyluria again disappeared spontaneously and recurred sporadically over the next two years in a patient who remained in good physical condition. The etiology of chyluria in a patient without filaria infestation is problematic, particularly when the most common causes (tuberculosis, neoplasia, trauma) are excluded as in our case. The asymmetry of the face, together with cutaneous dyschromia and the presence of a subarachnoidea cyst in the right temporal region suggested our patient had multiple congenital malformations.


Assuntos
Anormalidades Múltiplas , Quilo , Doenças Linfáticas/complicações , Sistema Linfático/anormalidades , Doenças Urológicas/etiologia , Adolescente , Humanos , Doenças Linfáticas/diagnóstico por imagem , Linfografia , Masculino , Recidiva , Fatores de Tempo , Urina/química
18.
Recenti Prog Med ; 82(1): 39-44, 1991 Jan.
Artigo em Italiano | MEDLINE | ID: mdl-2028076

RESUMO

The role of free radicals has been suggested in many different diseases; the molecular mechanisms of radical-induced damage have been widely investigated: the main effects on cellular components are lipid peroxidation, protein denaturation and DNA damage causing alteration in membrane functions, impaired enzyme activity and genetic alterations, including cancer. Since oxidative metabolism produces some radicals, aerobic organisms acquired a complex defensive system against radical attack, based on localization of oxidative reactions, enzymes that scavenge free radicals or their products and antioxidant vitamins. Diseases may arise from increased exposure to radicals or from impaired efficiency of protective systems. The role of oxygen radicals in cancerogenesis, alcoholic liver disease and the aging process is also briefly discussed.


Assuntos
Envelhecimento , Radicais Livres , Hepatopatias/etiologia , Neoplasias/etiologia , Idoso , Animais , Antioxidantes , Dano ao DNA , Humanos , Peroxidação de Lipídeos , Hepatopatias Alcoólicas/etiologia , Desnaturação Proteica
19.
Recenti Prog Med ; 80(1): 4-8, 1989 Jan.
Artigo em Italiano | MEDLINE | ID: mdl-2523552

RESUMO

In the present study we evaluated the alterations of plasma levels of dehydroepiandrosterone sulphate (DHEA-S) and of steroid-derivatives urinary excretion in cirrhotic patients compared with normal controls. 107 patients have been studied: 45 affected by liver cirrhosis (22 males and 23 females) both in compensated and in ascitic state, and 62 healthy controls (32 males and 30 females). In all patients we assayed plasma DHEA-S by RIA as well as common liver function tests; moreover gaschromatographic profile of adrenal steroid excretion was performed in daily urine. Our findings show a significantly lower DHEA-S in cirrhotic patients compared with healthy controls, both males (451.7 SD 440.3 ng/ml vs 1438.3 SD 604.8, p less than 0.001) and females (225.5 SD 152.6 ng/ml vs 974.0 SD 405.7, p less than 0.001). Variance analysis confirmed that the difference was significant both for compensated and uncompensated ones. We also found some interesting relationships between DHEA-S and liver function tests, cholesterol and age. Urinary steroids were markedly low in both sexes, particularly adrenal sexual fraction. Our data show clear disfunction in DHEA-S metabolism in liver cirrhosis, partially related with the severity of the disease.


Assuntos
Androstanos/urina , Desidroepiandrosterona/sangue , Cirrose Hepática , Adulto , Idoso , Desidroepiandrosterona/análogos & derivados , Feminino , Humanos , Cirrose Hepática/sangue , Cirrose Hepática/urina , Masculino , Pessoa de Meia-Idade
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