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1.
Acta Neurochir (Wien) ; 157(6): 1069-76; discussion 1076, 2015 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-25911298

RESUMO

BACKGROUND: Anatomical and surgical textbooks give almost no attention to the intradural communications between dorsal rootlets of adjacent spinal nerves. These communications can be of significance in various neurosurgical procedures and clinical conditions of the region. METHODS: The spinal cord of six formaldehyde-fixed cadavers was dissected from C1-S5. The dorsal rootlets of the spinal nerves were exposed via a posterior approach and communications between adjacent spinal nerves were documented. RESULTS: The frequency of communication between adjacent dorsal rootlets of the spinal nerves showed variations among spinal levels. Thirty-eight dorsal rootlet communications were observed in six cadavers (12 sides) and 20 (52.6%) were at cervical levels, 14 (36.8%) at thoracic levels, and four (10.5%) at lumbar levels. The majority of communications were observed on the left side (65.8%). Communications were most frequently observed at cervical (C4-C5, C5-C6) and upper thoracic (T1-T2) levels and seen least frequently at lower thoracic and lumbar levels. No communications were observed at sacral levels. Five types of communication were observed: I. oblique ascending, II. oblique descending III. short Y, IV. long Y and V shaped. None of the communication extended beyond one segment at any spinal level. The occurrence of such dorsal rootlet communications ranged from 3 to 7 for each cadaver and the mean was 4.8 ± 1.3. Histological sections from various levels of the dorsal rootlet communications showed that all consisted of myelinated fibers of varying diameters. CONCLUSIONS: Such communications may lead to misinterpretation of the pathology on the basis of clinical signs and symptoms and also should be considered in rhizotomy.


Assuntos
Comunicação Celular/fisiologia , Dura-Máter/anatomia & histologia , Raízes Nervosas Espinhais/anatomia & histologia , Nervos Espinhais/anatomia & histologia , Idoso , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Rizotomia
2.
J Craniofac Surg ; 26(5): 1663-7, 2015 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-26114521

RESUMO

AIM: The major aim of the present anatomical study was to demonstrate the anatomical structures that can be visualized using the supraorbital keyhole approach, both endoscopically and microscopically, from an eyebrow incision to intracranial structures. Furthermore, it defines an optimal craniotomy for surgery. METHODS: Fine dissection was performed on each side of 5 formalin-fixed adult cadavers according to the surgical procedures of the supraorbital keyhole approach, and each step was documented both endoscopically and microscopically. Furthermore, the distance between the superior temporal line and the supraorbital notch/foramen was measured from the 10 total sides of the 5 cadavers and from the 118 sides of the 59 autopsies. RESULTS: Tumors and aneurysms of the anterior cranial fossa can be visualized during the supraorbital keyhole approach. The average distance between the superior temporal line and the supraorbital notch/foramen was measured. The distance obtained from the autopsies on the 25 females was 31.56 ±â€Š4.03  mm on the right side and 31.04 ±â€Š5.40  mm on the left side. The average distance obtained from the autopsies on the 34 males was 34.00 ±â€Š4.59  mm on the right side and 33.59 ±â€Š5.41  mm on the left side. There was no statistically significant difference between right and left in the female and male autopsies or between sexes. CONCLUSIONS: This anatomical study showed that structures in the anterior and middle cranial fossa can be reached via the supraorbital keyhole craniotomy approach with minimal brain retraction and adequate exposure and with minimal craniotomy size.


Assuntos
Craniotomia/métodos , Órbita/cirurgia , Adulto , Idoso , Encéfalo/anatomia & histologia , Encéfalo/irrigação sanguínea , Cadáver , Cefalometria/métodos , Fossa Craniana Anterior/anatomia & histologia , Fossa Craniana Média/anatomia & histologia , Nervos Cranianos/anatomia & histologia , Dissecação/métodos , Endoscopia/métodos , Sobrancelhas/anatomia & histologia , Feminino , Humanos , Aneurisma Intracraniano/patologia , Masculino , Microcirurgia/métodos , Pessoa de Meia-Idade , Neoplasias Cranianas/patologia , Osso Temporal/anatomia & histologia , Osso Temporal/cirurgia
3.
Neurol Neurochir Pol ; 49(6): 358-66, 2015.
Artigo em Inglês | MEDLINE | ID: mdl-26652869

RESUMO

BACKGROUND: Thoracolumbar burst fractures are common clinical entity encountered in neurosurgical practice, accounting for 10-20% of all spinal fractures. Clinical picture could be devastating due to severe neurological deficits which lead the patients dependent both socially and emotionally. MATERIALS AND METHODS: This study compared two groups of patients who were operated because of thoracolumbar burst fracture secondary to spinal trauma in terms of neurologic deficits, degree of improvement, and radiologic measurements at one-year follow-up. The first group (group I) included the patients who underwent posterior total laminectomy, peroperative reduction of intracanal bone fragments, and posterior spinal instrumentation and the second group (group II) included the patients who underwent total laminectomy, and spinal instrumentation without reduction of free bone fragments. RESULTS: Neither group showed significant correlation with any measurement parameter. Radiological assessments and clinical improvements did not disclosed significant difference between the two groups at one-year follow-up. CONCLUSION: Retropulsion of free bone fragments extend the time of surgery and causes complications. This study found that there is no need to retropulse the bone fragments in the spinal canal in patients with unstable burst fractures who underwent total laminectomy and posterior long segment stabilization.


Assuntos
Fixação Interna de Fraturas/métodos , Laminectomia/métodos , Fraturas da Coluna Vertebral/cirurgia , Fusão Vertebral/métodos , Adulto , Feminino , Seguimentos , Fixação Interna de Fraturas/efeitos adversos , Fixação Interna de Fraturas/instrumentação , Humanos , Laminectomia/efeitos adversos , Vértebras Lombares/lesões , Vértebras Lombares/cirurgia , Masculino , Estudos Retrospectivos , Fusão Vertebral/efeitos adversos , Fusão Vertebral/instrumentação , Vértebras Torácicas/lesões , Vértebras Torácicas/cirurgia , Resultado do Tratamento
4.
Acta Neurochir (Wien) ; 156(8): 1523-5, 2014 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-24821653

RESUMO

BACKGROUND: The sine-wave-shaped skin incision is a technique that minimizes skin-related complications near burr hole caps after electrode placement for deep-brain stimulation (DBS). METHODS: Between 2011 and 2013, 54 DBS electrodes were implanted in 27 consecutive patients with Parkinson's disease (PD), essential tremor, or dystonia. The sine-wave incision was used in 26 patients and conventional bilateral linear scalp incisions were used in one patient. RESULTS: None of the patients whose operations involved sine-wave-shaped incisions developed hardware-linked complications such as skin infection or skin erosion. The one patient who underwent conventional bilateral linear scalp incisions developed a skin infection. CONCLUSION: By preserving the vascular anatomy of the scalp and reducing skin tension at the wound site, the sine-wave-shaped incision promotes wound healing.


Assuntos
Estimulação Encefálica Profunda , Distonia/cirurgia , Tremor Essencial/cirurgia , Doença de Parkinson/cirurgia , Couro Cabeludo/cirurgia , Cicatrização/fisiologia , Adulto , Idoso , Idoso de 80 Anos ou mais , Eletrodos Implantados , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Estudos Retrospectivos
5.
Acta Neurochir (Wien) ; 156(12): 2351-8, 2014 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-25331322

RESUMO

BACKGROUND: The posterolateral sulcus (PLS) is an important surgical landmark, especially for DREZ (dorsal root entry zone) operations. METHODS: The present study aimed to show the variations of the PLS using human spinal cord histological sections and report the variability in the number of dorsal rootlets of the spinal nerves in each the spinal cord segment. Further, measure the height and width of the dorsal horn on histological sections for cervical, thoracic, and lumbar levels. RESULTS: The results of the present study showed various patterns of PLS 1.clearly present PLS, 2. short PLS, 3. absent PLS or 4. irregular PLS. Height and width measurements of the dorsal horn showed that the average width was greatest at lower cervical (0.48 ± 0.04 mm) and least at lower thoracic levels (0.41 ± 0.04 mm), whereas the average height was greatest at upper cervical (3.0 ± 0.06 mm) and smallest at lower lumbar levels (1.8 ± 0.08 mm). The average number of rootlets varied considerably, at cervical level it was 7.6 ± 1.4 mm, at thoracic 6.6 ± 0.8 mm and at lumbar 6.1 ± 0.4 mm. CONCLUSIONS: The detailed anatomy of the variations of the PLS and the average number of rootlets at each spinal level can increase the success of regional surgery. Further, fine measurements on histological sections can give detailed knowledge on the size necessary for lesioning in DREZ operations.


Assuntos
Gânglios Espinais/anatomia & histologia , Corno Dorsal da Medula Espinal/anatomia & histologia , Idoso , Nervos Cranianos/anatomia & histologia , Humanos , Masculino , Pessoa de Meia-Idade
6.
J Craniofac Surg ; 25(6): 2199-204, 2014 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-24448535

RESUMO

In this study, we aimed to investigate the morphometric and morphologic structures of the confluens sinuum (CS) and related structures with a silicone painting technique. We studied 30 cadavers. Twelve of them were washed with alcohol and filled with a silicone painting technique via the vena jugularis interna, internal carotid artery, and vertebral artery. The other 18 were autopsied postmortem. The CS and related structures were dissected under microscope. Their anatomy was investigated, and variations were noted. The diameters of the sinus sagittalis superior (SSS), CS, occipital sinus (OS), sinus rectus (SR), and bilateral transverse sinus (TS), and the angle between SSS and SR were measured. The mean diameters were 11.7 mm for SSS, 22.3 mm for CS, 5.25 mm for OS, 7.5 mm for SR, and 9.7 (right) and 9.1 mm (left) for TS. The angle between the SR and SSS was 58°. There was no difference in the bilateral venous structures that drained to the SSS and TS. There was an extra drainage to the CS from the left side in 4 cases. The right TS was located superiorly in 7 cases compared with the left TS, and this process was correlated with the type of CS. A septum in the SSS was detected in 2 cases. In addition, we encountered an OS in 80% of the cases. We conclude that the septum inside the CS affects the dominancy of the TS, the angle between the SSS and SR, and the other venous variations.


Assuntos
Cavidades Cranianas/anatomia & histologia , Adulto , Variação Anatômica , Cadáver , Artéria Carótida Interna/anatomia & histologia , Cefalometria/métodos , Feminino , Humanos , Veias Jugulares/anatomia & histologia , Masculino , Pessoa de Meia-Idade , Fotografação/métodos , Técnicas de Réplica , Silicones/química , Seio Sagital Superior/anatomia & histologia , Seios Transversos/anatomia & histologia , Artéria Vertebral/anatomia & histologia
7.
Orthop Surg ; 16(10): 2410-2418, 2024 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-39043611

RESUMO

OBJECTIVE: For degenerative diseases accompanied by cervical malalignment, the starting and ending points of fixation for better cervical sagittal alignment and clinical results are not as clear as the thoracolumbar region. In this study we aimed to compare the effects of posterior subaxial cervical fixation (PSCF), posterior cervical fixation extending to the upper thoracic region and posterior upper cervical fixation extending to the upper thoracic region on cervical sagittal alignment. METHODS: Sixty-three patients who underwent posterior cervical and cervical-up thoracic fixation were retrospectively analyzed in a comparative study. The procedures that we performed from May 2019 to March 2022 on these 63 patients were: (1) C3-C6 group-posterior subaxial cervical fixation; (2) Subaxial-T2 group-posterior subaxial cervicothoracic fixation (PSCTF); (3) C2-T2 upper thoracic posterior fixation group. The C3-C6 group had 27 patients, Subaxial-T2 group had 24, and C2-T2 group had 12. We determined the minimum follow-up period as 12 months. C0-2, C2-7 lordosis angle, sagittal vertical axis (SVA), C2 slope, C7 slope, T1 slope, cervical slope, neck slope, and thoracic inlet angle (TIA) measurements were made in three patient groups. Comparatively, cervical sagittal alignment was evaluated. RESULT: In the C2-T2 group, a significant increase in C2-C7 lordosis, decrease in C2 slope, and increase in TS-CL were observed. Significant C2-C7 lordosis decrease, C2 slope increase, and TS-CL decrease were observed in the C3-C6 group. A significant increase in C2-C7 lordosis and a decrease in C2 slope were observed in the subaxial-T2 group. No significant change was observed in the TS-CL angle. CONCLUSION: In cervical degenerative disorders accompanied by cervical malalignment, we recommend the C2-T2 fixation method, which provides the desired C2-C7 lordosis, SVA within the normal range, and the best Neck Disability Index results.


Assuntos
Vértebras Cervicais , Fusão Vertebral , Vértebras Torácicas , Humanos , Vértebras Cervicais/cirurgia , Vértebras Cervicais/diagnóstico por imagem , Masculino , Estudos Retrospectivos , Feminino , Pessoa de Meia-Idade , Vértebras Torácicas/cirurgia , Vértebras Torácicas/diagnóstico por imagem , Fusão Vertebral/métodos , Idoso , Adulto , Lordose/cirurgia , Lordose/diagnóstico por imagem
8.
World Neurosurg ; 187: e825-e831, 2024 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-38719078

RESUMO

BACKGROUND: Eugenol has various curative properties. It affects the dilatation of cerebral arteries through voltage-dependent Ca2+ channel inhibition. This study is the first to explore the impact of eugenol on neuroprotection and vasospasm in an experimental subarachnoid hemorrhage (SAH) model. METHODS: Twenty-four adult male Sprague-Dawley rats were indiscriminately separated into 3 groups: the control group (n = 8), the SAH group (n = 8), and the eugenol group (n = 8). A double-bleeding method was used. The eugenol group received intracisternal eugenol (Sigma-Aldrich, St. Louis, MO, USA) at 30 µg/20 µl after induction of SAH. On the day 7, all groups were euthanized. Measurements were taken for basilar artery wall thickness, lumen diameter, serum endothelin-1 (ET-1), and caspase-3 levels. RESULTS: The eugenol group exhibited significantly lower wall thickness, ET-1, oxidative stress index, and caspase-3 levels compared to the SAH group. In comparison to the control group, the eugenol group showed a higher oxidative stress index along with higher ET-1 and caspase-3 levels, but these differences were not statistically significant. Wall thickness was significantly higher in the eugenol group than in the control group. CONCLUSIONS: This study represents the first literature exploration of intrathecal eugenol's impact on vasospasm induced after experimental SAH. Administration of intrathecal eugenol demonstrates a positive effect on the treatment of experimental vasospasm as well as on the reduction of oxidative stress and apoptosis.


Assuntos
Modelos Animais de Doenças , Eugenol , Ratos Sprague-Dawley , Hemorragia Subaracnóidea , Vasoespasmo Intracraniano , Animais , Eugenol/administração & dosagem , Eugenol/farmacologia , Hemorragia Subaracnóidea/complicações , Hemorragia Subaracnóidea/tratamento farmacológico , Vasoespasmo Intracraniano/tratamento farmacológico , Vasoespasmo Intracraniano/etiologia , Masculino , Ratos , Injeções Espinhais , Estresse Oxidativo/efeitos dos fármacos , Artéria Basilar/efeitos dos fármacos , Artéria Basilar/patologia , Fármacos Neuroprotetores/administração & dosagem , Endotelina-1/sangue , Caspase 3/metabolismo
9.
Acta Neurochir (Wien) ; 155(11): 2183-9; discussion 2189, 2013 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-24036672

RESUMO

BACKGROUND: Only limited attention has been paid to the anatomy and clinical importance of the falcine venous plexus. The aim of this study was to evaluate the falcine venous plexus anatomically using scanning electron microscopy (SEM), and to provide guidance for neurosurgical approaches. METHODS: Latex or ink was injected into the superior and inferior sagittal sinus. The falcine venous plexus lying within the connective tissue of the falx cerebri was observed by dividing the falx into thirds (anterior, middle and posterior). Further, the SEM appearance of the falcine venous plexus was evaluated. RESULTS: The anterior third of the falx cerebri consisted of small diameter falcine venous vessels. These vessels were localized close to either the superior or inferior sagittal sinus, and none extended as far as mid-falx cerebri levels in any of the 16 cases. They communicated with either superior or inferior sagittal sinuses, but not with both of these sinuses. In the middle third of the falx cerebri, the majority of the vessels of the falcine venous plexus had larger diameter compared to those of the anterior third. These vessels extended the length of the falx cerebri levels. They communicated with both superior and inferior sagittal sinuses. In the posterior third of the falx cerebri, the vessels of the falcine venous plexuses had the largest diameter and were located at the junction of the inferior sagittal sinus and the straight sinus. They were localized at the lower two-thirds of the falx cerebri. In all cases, the dense venous networks communicated with the inferior sagittal sinus but not with the superior sagittal sinus. The falcine venous plexus observed in the posterior third of the falx cerebri was denser than in the anterior and middle portions. The SEM revealed small vessels whose diameter ranged between 42 and 138 µm. The vessels of the falcine venous plexus in the anterior third had a mean diameter of 0.42 ± 0.1 mm, in the middle third a mean diameter of 0.87 ± 0.17 mm, and in the posterior third, 1.38 ± 0.21 mm. CONCLUSION: The falcine venous plexus is a network of venous channels that exists within the connective tissue of the falx; the sizes and patterns of communication of these structures showed regional differences. Neurosurgeons should be aware of the regional differences when making an incision or puncturing the falx during a surgical approach.


Assuntos
Encéfalo/anatomia & histologia , Cavidades Cranianas/anatomia & histologia , Idoso , Encéfalo/ultraestrutura , Cadáver , Cavidades Cranianas/ultraestrutura , Dura-Máter/anatomia & histologia , Feminino , Humanos , Masculino , Microscopia Eletrônica de Varredura/métodos , Pessoa de Meia-Idade , Neuroanatomia/métodos , Veias/patologia
10.
Br J Neurosurg ; 27(6): 812-4, 2013 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-23458576

RESUMO

BACKGROUND: A neurosurgical laboratory training model is designed for trainees in microneurosurgery to learn to handle surgical microscopes and microneurosurgical instruments. The silicone injection of a fresh cadaveric cow cranium is an alternative to using a cadaveric human brain for becoming familiar with the cerebellopontine angle (CPA) via the retrosigmoid approach. To report an improved method for training in the CPA via the retrosigmoid approach, using a fresh cadaveric cow cranium injected with silicone. METHODS: The material consists of a cadaveric cow brain injected with silicone. Preparation consists of irrigation of the major vessels followed by injection of silicone, coloured either red or blue. RESULTS: A three-step approach was designed to simulate microneurosurgical dissection along with the cerebellopontine angle and to dissect cranial nerves emerging from the brain stem. CONCLUSION: This laboratory training model is useful in allowing trainees to gain experience with the use of an operating microscope and familiarity with the CPA via the retrosigmoid approach. The aim of this study was to develop a novel model and to adapt it to create a life-like neurosurgical training system.


Assuntos
Revascularização Cerebral/educação , Revascularização Cerebral/métodos , Cavidades Cranianas/anatomia & histologia , Neurocirurgia/educação , Procedimentos Neurocirúrgicos/educação , Procedimentos Neurocirúrgicos/métodos , Animais , Cadáver , Bovinos , Ângulo Cerebelopontino/anatomia & histologia , Ângulo Cerebelopontino/cirurgia , Competência Clínica , Nervos Cranianos/anatomia & histologia , Nervos Cranianos/cirurgia , Cavidades Cranianas/cirurgia , Humanos , Silicones
11.
Rev Assoc Med Bras (1992) ; 69(1): 18-23, 2023.
Artigo em Inglês | MEDLINE | ID: mdl-36820710

RESUMO

OBJECTIVE: This study aimed at investigating whether there is a relationship between 7- or 30-day mortality and mean platelet volume, platelet distribution width, platelet count-to-total lymphocyte count ratio, or red cell distribution width in patients with traumatic brain injury. METHODS: We retrospectively analyzed intensive care unit patients with traumatic brain injury. We recorded patients' ages; genders; diagnoses; Glasgow Coma Scale scores; length of intensive care unit stay (in days); mean platelet volume, platelet distribution width, platelet count-to-total lymphocyte count ratio, and red cell distribution width values upon hospital admission; and health on the 7th and 30th days of their stays. RESULTS: We analyzed data from 110 patients. Of these, 84 (76.4%) were male and 26 (23.6%) were female. On the 7- and 30-day mortality evaluations, compared to the living patients, the deceased patients had a significantly higher median age and a significantly lower median Glasgow Coma Scale. Thus, increased age and lower Glasgow Coma Scale scores were associated with increased 7- and 30-day mortality rates. mean platelet volume and platelet distribution width values were similar in living and deceased patients. platelet count-to-total lymphocyte count ratio values were lower in deceased patients, but this difference was not statistically significant. Within 30 days after traumatic brain injury, deceased patients' red cell distribution width values were significantly elevated in deceased patients compared to those of living patients. CONCLUSION: Mean platelet volume, platelet distribution width, and platelet count-to-total lymphocyte count ratio values were not associated with 7- and 30-day mortality, whereas only elevated red cell distribution width was associated with 30-day mortality.


Assuntos
Lesões Encefálicas Traumáticas , Índices de Eritrócitos , Humanos , Masculino , Feminino , Estudos Retrospectivos , Volume Plaquetário Médio , Contagem de Plaquetas
12.
Acta Neurochir (Wien) ; 154(7): 1229-34, 2012 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-22555553

RESUMO

BACKGROUND: It is widely believed that the main function of denticulate ligaments (DLs) is to stabilize the spinal cord within the vertebral canal. The aim of this study was to assess the anatomical and histological structure of the DLs and to document any regional differences. METHODS: Five formalin-fixed adult cadavers were used. The DLs were exposed via the posterior approach, and detailed anatomy and histology of these structures were documented. RESULTS: The main findings were: (1) each DL is composed of a single narrow fibrous strip that extends from the craniovertebral junction to T12, and each also features 18-20 triangular extensions that attach to the dura at their apices; (2) the triangular extensions are smaller and more numerous at the cervical levels, and are larger and less numerous at the thoracic levels; (3) the apices of the extensions attach to the dura via fibrous bands at cervical levels (each band 3-5 mm long) and lower thoracic levels (21-26 mm long), whereas they attach directly to the dura at upper thoracic levels; (4) the narrow fibrous strip of the DL features longitudinally oriented collagen fibers, whereas the triangular extensions are composed of transverse and obliquely oriented collagen fibers. The collagen fibers are thicker and more abundant at the cervical than at the thoracic levels. CONCLUSION: DL histology and anatomy are strongly correlated with the function of this structure at different spinal levels. It is important to have accurate knowledge about DLs as these structures are relevant for clinical procedures that involve the spinal cord or craniovertebral junction.


Assuntos
Ligamentos/anatomia & histologia , Canal Medular/anatomia & histologia , Medula Espinal/anatomia & histologia , Adulto , Idoso , Vértebras Cervicais/anatomia & histologia , Dura-Máter/anatomia & histologia , Feminino , Humanos , Vértebras Lombares/anatomia & histologia , Masculino , Pessoa de Meia-Idade , Amplitude de Movimento Articular/fisiologia , Valores de Referência , Sacro/anatomia & histologia , Vértebras Torácicas/anatomia & histologia
13.
Turk Neurosurg ; 32(5): 786-792, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-35929040

RESUMO

AIM: To investigate the angiogenic effects of bevacizumab and imatinib on different meningioma tissue grades. MATERIAL AND METHODS: In this study, in silico analysis of angiogenesis-related gene expression was carried out using previously reported datasets. Messenger ribonucleic acid expressions of VEGFA, VEGFB, PDGFRA, and PDGFRB genes were obtained from two different meningioma transcriptome datasets. The effect of antiangiogenic drugs, bevacizumab and imatinib, on meningiomainduced vascularization was assessed by using rat corneal angiogenesis assay (CAA). RESULTS: Bevacizumab and imatinib both significantly reduced meningioma-induced neovascularization in the CAA model. CONCLUSION: The angiogenic characteristics of meningiomas may be suppressed by using antiangiogenic drugs to prevent neovascularization, thus improving prognosis.


Assuntos
Neovascularização da Córnea , Neoplasias Meníngeas , Meningioma , Inibidores da Angiogênese/farmacologia , Inibidores da Angiogênese/uso terapêutico , Animais , Bevacizumab/farmacologia , Bevacizumab/uso terapêutico , Neovascularização da Córnea/tratamento farmacológico , Mesilato de Imatinib/uso terapêutico , Neoplasias Meníngeas/tratamento farmacológico , Neoplasias Meníngeas/metabolismo , Meningioma/tratamento farmacológico , Meningioma/metabolismo , Neovascularização Patológica/tratamento farmacológico , Neovascularização Patológica/metabolismo , RNA/uso terapêutico , Ratos , Receptor beta de Fator de Crescimento Derivado de Plaquetas/uso terapêutico
14.
Cureus ; 14(8): e27907, 2022 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-36134043

RESUMO

Objective Surgery for far lateral lumbar disc herniation (FLLDH) hernias is different than surgery for median and paramedian disc hernias. Our study offers a minimally invasive surgical technic for far lateral disc herniations. Methods The results of the midline surgical approach in 18 patients diagnosed with FLLDH were evaluated retrospectively. Results A total of 18 patients (7 females, 11 males), with a mean age of 57.9±9.4 years (range: 35-71 years), were included in the analyses. Three patients (16.7%) had lesions at the left L3-L4 level, six patients (33.3%) on the left L4-L5 level, five patients (27.8%) on the right L3-L4 level, and four patients (22.2%) on the right L4-L5 level. All patients had low back and leg pain. These complaints completely regressed after surgery. Conclusion This study presents a review of a consecutive series of patients who underwent minimally invasive surgery for FLLDH using a midline approach.

15.
Ulus Travma Acil Cerrahi Derg ; 28(7): 997-1007, 2022 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-35775670

RESUMO

BACKGROUND: The aim of this study is to contribute to the literature by determining the morphometric reference values of the bony structures in the craniovertebral junction (CVJ) from computer tomography (CT) images of the pediatric age group. METHODS: In this study, CT's of 151 simple trauma patients aged between 3 and 15 years between 2016 and 2020 were evaluated. All CT examinations were performed using a 32-slice CT and included images of the skull base and C1-C2 junction. A total of 10 measurements were obtained from these images, including Wachenheim clivus canal angle (WCA), Welcher basal angle (WBA), Cran-iocervical tilt angle (CCT), power ratio (PR), Atlantodens interval, McRae Line (MRL), McRae - Dens distance, basion-dens interval (BDI), basion-axis interval (BAI), and atlantooccipital measurement (AOM). RESULTS: In comparison between gender groups, MRL (p=0.011) and AOM (p<0.001) measurements were found to be significantly higher in males. McRae-Dens distance, BDI, and AOM were significantly higher in patients aged 3-9 years (respectively, p=0005, p=0.003, p<0.001), and BAI (p=0.001) was significantly higher in patients aged 10-15 years. The McRae - Dens distance (p=0.119) was similar between patients with and without terminal ossicle in odontoid apex. But BDI of patients without terminal ossicle was significantly higher (p=0.048). All parameters, except the WCA, WBA, CCT, and PR, were statistically significantly correlated with the patient age (respectively, p=0.21, p=0.13, p=0.70, p=0.99). CONCLUSION: In this study, the morphometric reference values of the bone structures at the CVJ were determined from the CT images of the pediatric age group.


Assuntos
Cabeça , Tomografia Computadorizada por Raios X , Adolescente , Criança , Pré-Escolar , Fossa Craniana Posterior , Humanos , Masculino , Exame Físico
16.
Rev. Assoc. Med. Bras. (1992, Impr.) ; Rev. Assoc. Med. Bras. (1992, Impr.);69(1): 18-23, Jan. 2023. tab
Artigo em Inglês | LILACS-Express | LILACS | ID: biblio-1422584

RESUMO

SUMMARY OBJECTIVE: This study aimed at investigating whether there is a relationship between 7- or 30-day mortality and mean platelet volume, platelet distribution width, platelet count-to-total lymphocyte count ratio, or red cell distribution width in patients with traumatic brain injury. METHODS: We retrospectively analyzed intensive care unit patients with traumatic brain injury. We recorded patients' ages; genders; diagnoses; Glasgow Coma Scale scores; length of intensive care unit stay (in days); mean platelet volume, platelet distribution width, platelet count-to-total lymphocyte count ratio, and red cell distribution width values upon hospital admission; and health on the 7th and 30th days of their stays. RESULTS: We analyzed data from 110 patients. Of these, 84 (76.4%) were male and 26 (23.6%) were female. On the 7- and 30-day mortality evaluations, compared to the living patients, the deceased patients had a significantly higher median age and a significantly lower median Glasgow Coma Scale. Thus, increased age and lower Glasgow Coma Scale scores were associated with increased 7- and 30-day mortality rates. mean platelet volume and platelet distribution width values were similar in living and deceased patients. platelet count-to-total lymphocyte count ratio values were lower in deceased patients, but this difference was not statistically significant. Within 30 days after traumatic brain injury, deceased patients' red cell distribution width values were significantly elevated in deceased patients compared to those of living patients. CONCLUSION: Mean platelet volume, platelet distribution width, and platelet count-to-total lymphocyte count ratio values were not associated with 7- and 30-day mortality, whereas only elevated red cell distribution width was associated with 30-day mortality.

17.
J Neurosurg Sci ; 61(2): 151-156, 2017 04.
Artigo em Inglês | MEDLINE | ID: mdl-25336049

RESUMO

BACKGROUND: Increased angiogenic potential of cerebrovascular malformations during pregnancy may help to explain the complications of arteriovenous malformations (AVMs) in this group of patients. This experimental study investigated the effect of pregnancy on angiogenic activity of implanted AVM tissue samples. METHODS: A subject group of 10 pregnant rats and 10 non-pregnant rats as controls were used. Surgical AVM resection samples were implanted into the micropocket created in both eyes of each animal. Vascular development was assessed by vessel count throughout the study period. In addition, immunohistochemical studies were done for vascular endothelial growth factor (VEGF), platelet derived growth factor (PDGF), and their receptors (VEGFR, PDGFR). RESULTS: Statistically significant increase in the number of vessels was found in both groups (P<0.0001); however, the increase in the pregnant group was greater (P=0.0032). The difference between the two groups was evident at the 25th day of the experiment. Despite both groups showed increased level, there was no difference with the level of VEGF, VEGF receptor, PDGF, or PDGF receptor (P>0.05 for all comparisons). CONCLUSIONS: Findings of this study suggest that angiogenic activity of AVM tissues may increase during late pregnancy, hence physicians should inform pregnant patients with AVM of the potential risk.


Assuntos
Malformações Arteriovenosas/complicações , Malformações Arteriovenosas/patologia , Neovascularização Patológica/patologia , Indutores da Angiogênese/farmacologia , Animais , Malformações Arteriovenosas/metabolismo , Modelos Animais de Doenças , Feminino , Humanos , Neovascularização Patológica/diagnóstico , Gravidez , Ratos Sprague-Dawley , Receptores do Fator de Crescimento Derivado de Plaquetas/metabolismo , Receptores de Fatores de Crescimento do Endotélio Vascular/metabolismo , Risco
18.
Medicine (Baltimore) ; 95(4): e2521, 2016 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-26825888

RESUMO

Sacrum fractures are rare pathologies seen after spinal traumas. The incidence of a sacral fracture after trauma is 0.6% in childhood. A Malgaigne fracture is composed of fractures and dislocations of the anterior and posterior regions of the pelvis. This is the first reported case of Malgaigne fracture during childhood. A 12-year-old girl was admitted to our emergency room after having suffered a fall. Radiological tests revealed a zone 3 sacral fracture according to the Denis scoring, a subtype 2 sacral fracture according to the Roy-Camille classification, and a detachment in the symphysis pubis. Appropriate load distribution through a bilateral L5-S1-S2 transpedicular screw and a bilateral iliac wing screw, as well as neural decompression were performed together with an S1-S2 total laminectomy. It is very difficult to make a generalization for treatment of sacral fractures and Malgaigne fractures in childhood due to the small number of patients. Each patient should be individualized and lumbosacroiliac instability should be treated.


Assuntos
Fixação Interna de Fraturas , Luxações Articulares/cirurgia , Traumatismo Múltiplo/cirurgia , Articulação Sacroilíaca/lesões , Sacro/lesões , Fraturas da Coluna Vertebral/cirurgia , Fraturas do Tornozelo/diagnóstico por imagem , Criança , Feminino , Humanos , Luxações Articulares/diagnóstico por imagem , Laminectomia , Traumatismo Múltiplo/diagnóstico por imagem , Radiculopatia/etiologia , Radiculopatia/cirurgia , Radiografia , Articulação Sacroilíaca/cirurgia , Sacro/cirurgia , Fraturas da Coluna Vertebral/diagnóstico por imagem
19.
Turk Neurosurg ; 26(3): 404-10, 2016.
Artigo em Inglês | MEDLINE | ID: mdl-27161468

RESUMO

AIM: The aim of this study is to compare the different types of fusion materials known as PEEK cages used during anterior cervical discectomy (ACD) surgery. MATERIAL AND METHODS: A total of 67 patients were operated and evaluated retrospectively under two groups (group A: 35 PEEK cage patients, group B: 32 bladed PEEK cage patients) between 2009 and 2013. Preoperative and postoperative (postoperative first day, postoperative 1st, 3rd and 12-24th mo) images were obtained. The cervical disc heights, cervical and segmental lordotic angles of the operated levels were calculated. Pain assessment was performed and fusion rates were also compared. Mann-Whitney U test was applied to compare the outcomes. RESULTS: The pain scores (especially for arm pain) were decreased significantly in both groups after surgery regardless of the type of operation technique (P < 0.05). There were no significant differences between both groups at the disc height measurements of operated levels in postoperative periods (P > 0.05). In addition to these; there was no significant difference between both groups of segmental and cervical lordodic angles in postoperative periods (P > 0.05). There was no statistically significant difference between the fusion rates and pain scores of both groups (P > 0.05). CONCLUSION: The PEEK cage and bladed PEEK cages can be used safely to obtain fusion after ACD.


Assuntos
Discotomia/métodos , Fixadores Internos , Fusão Vertebral/métodos , Adulto , Benzofenonas , Vértebras Cervicais/patologia , Vértebras Cervicais/cirurgia , Feminino , Humanos , Disco Intervertebral/diagnóstico por imagem , Disco Intervertebral/patologia , Disco Intervertebral/cirurgia , Cetonas , Lordose/diagnóstico por imagem , Lordose/patologia , Lordose/cirurgia , Imageamento por Ressonância Magnética , Masculino , Pessoa de Meia-Idade , Medição da Dor , Dor Pós-Operatória/epidemiologia , Polietilenoglicóis , Polímeros , Estudos Retrospectivos , Resultado do Tratamento
20.
Turk Neurosurg ; 26(1): 97-104, 2016.
Artigo em Inglês | MEDLINE | ID: mdl-26768875

RESUMO

AIM: The objective of this study was to investigate the effect of using 2 different surgical techniques (curette or high-speed drill) in anterior cervical discectomy surgery on the healing of cases. MATERIAL AND METHODS: Fifty-four operated cervical disc hernia cases were retrospectively examined in 2 groups. Discectomy and osteophytectomy were carried out in Group A by using a high-speed drill, while a curette was used for group B. Preoperative and postoperative computerized tomography and direct radiography were performed. Cervical disc height, cervical and segmental lordotic angles were calculated. The visual analogue scale and Odom's criteria were used in the assessment of pain and clinical healing. The fusion ratio of both groups was compared. The Mann-Whitney U test was used to compare data from the groups. RESULTS: Satisfactory results were obtained in the groups where high-speed drill and curette were used. Independently from the surgical technique, pain scores were significantly reduced in both groups after surgery. No radiologically significant differences were identified between the two groups within the postoperative period. CONCLUSION: Either high-speed drill or curette can be chosen for the osteophytectomy and discectomy stages of anterior cervical discectomy operations.


Assuntos
Discotomia/instrumentação , Discotomia/métodos , Deslocamento do Disco Intervertebral/cirurgia , Fusão Vertebral/instrumentação , Fusão Vertebral/métodos , Adulto , Vértebras Cervicais/cirurgia , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Medição da Dor , Período Pós-Operatório , Estudos Retrospectivos , Tomografia Computadorizada por Raios X , Resultado do Tratamento
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