RESUMO
Growing resistance to current antiparasitic medications, both in livestock and in zoological species under human care, makes it imperative to evaluate available drugs on the market, such as eprinomectin. In this prospective study, five males and one female of reticulated (Giraffa reticulata; n = 2), Masai (Giraffa tippelskirchii; n = 1), Nubian (Giraffa camelopardalis; n = 2), and hybrid subspecies (n = 1) of giraffe, received 1.5 mg/kg eprinomectin topically along the dorsum. Using high-performance liquid chromatography, concentrations of eprinomectin in plasma samples collected at 0, 4, 24, and 48 h, and 7, 14, 21, and 28 d were evaluated following drug administration. Complete blood cell counts and biochemistry panels were performed before (n = 6) and after (n = 3) eprinomectin administration. Samples for modified double centrifugal fecal flotation (n = 6) were evaluated prior to eprinomectin administration to evaluate for endoparasites and were repeated after the study (n = 5). Noncompartmental pharmacokinetic analysis was applied to the data. The observed maximum plasma concentration was 11.45 ng/ml and the time of observed maximum concentration was 2.67 d. The mean terminal half-life was 5.16 d. No adverse effects were observed related to eprinomectin administration and no blood work changes were observed. Parasite loads decreased (n = 3) or did not change (n = 2) after eprinomectin administration. The mean peak plasma concentration of eprinomectin in giraffe was similar to that achieved in cattle, despite using three times the dose.
Assuntos
Anti-Helmínticos , Girafas , Ivermectina/análogos & derivados , Masculino , Humanos , Feminino , Animais , Bovinos , Anti-Helmínticos/uso terapêutico , Estudos Prospectivos , Administração Tópica , Ivermectina/uso terapêuticoRESUMO
Introducción: La búsqueda de la eficiencia en la atención a la salud de la población representa una prioridad para cada uno de los niveles de atención, por lo que es vital identificar los elementos que permitan una mejora continua en las instituciones. La gestión del conocimiento es utilizada para tal fin y se ha estudiado a la par de otras variables como: la cultura organizacional, el liderazgo y la disponibilidad y el uso de tecnologías de la información y comunicación. Objetivo: El objetivo del estudio fue analizar la relación de la gestión del conocimiento con estas variables en centros de atención primaria a las adicciones del noroeste de México. Métodos: Se aplicó un cuestionario (α = .977) a 80 profesionales de la salud que laboraban en esas instituciones. Se encontraron relaciones positivas, grandes y significativas entre la gestión del conocimiento y el liderazgo (r = .816, p <. 001) y entre la gestión del conocimiento y la cultura organizacional (r =. 802, p <. 001). Sin embargo, se encontró una correlación positiva y moderada con la variable tecnologías de la información y comunicación. Conclusiones: Se concluye que en los centros de atención primaria a las adicciones del noroeste de México la cultura organizacional y el liderazgo se consideran los factores más importantes para contribuir al éxito de la gestión del conocimiento, principalmente en la adquisición y la transferencia del conocimiento. Es importante considerar en estudios futuros los beneficios sociales y económicos de emplear la gestión del conocimiento en la toma de decisiones organizacionales.
Introduction: The search for efficiency in health care for the population signifies a priority for each level of care, so it is vital to identify the elements allowing continuous improvement in institutions. Knowledge management is used for this purpose and it has been studied along with other variables such as organizational culture, leadership and the availability and use of information and communication technologies. Objective: The objective of the study was to analyze the relationship of knowledge management with these variables in primary addiction care centers in Northwest Mexico. Methods: A questionnaire (α = .977) was applied to 80 health professionals who worked in these institutions. Positive, large and significant relationships were found among knowledge management and leadership (r = .816, p < .001) and among knowledge management and organizational culture (r = .802, p < .001). However, positive and moderate correlation was found with the information and communication technologies variable. Conclusions: It is concluded that in primary addiction care centers in Northwest Mexico, organizational culture and leadership are considered the most important factors to contribute to the success of knowledge management, mainly in the acquisition and transfer of knowledge. It is important to consider in future studies the social and economic benefits of using knowledge management in organizational decision making.
RESUMO
Resumen La Práctica Basada en Evidencia (PBE) es un proceso que inicia con el conocimiento de las evidencias disponibles y concluye con la selección de la mejor intervención para su implementación en escenarios clínicos lo cual impacta la efectividad de las intervenciones. Objetivo. Caracterizar el perfil de los terapeutas que laboran en 17 centros de tratamiento ambulatorio en adicciones del noroeste de México, además de sus conocimientos y habilidades en el uso de la PBE (fuentes de consulta, uso de manuales) y percepción de su autoeficacia. Método. Participaron 102 terapeutas, se contemplaron dos etapas: cuantitativa basada en la aplicación del CUTEA y cualitativa con aplicación de entrevista semi-estructurada, buscando contrastar las respuestas. Resultados. La mayoría de los participantes tuvo dificultad para describir el concepto de PBE, solo el 37.25% logró una adecuada definición sin embargo, reportaron altos niveles (95.91%) de autoeficacia para implementarla. En relación a las fuentes de consulta el 50% reportó utilizar cualquier buscador comercial en internet, mientras que el 46.08% referían usar los manuales de la institución. Al ingreso a su trabajo, no contaban con capacitación en adicciones ni en el área clínica. Discusión. Se aborda la necesidad del entrenamiento en la PBE y no solo en la implementación de tratamientos específicos.
Abstract Introduction. Evidence-Based Practice (EBP) is a process which starts with the knowledge of available evidence and concludes with the evaluation and selection of the best intervention for the implementation in clinical settings, this process impact the efficacy of the interventions. The variables which can impact on the EBP could be: personal and institutional variables and therapist skills and variables of the interventions. However, to make decisions in the clinical context, it has prevailed a position based on the risks and needs of the clients, which would justify using any treatment, regardless of its effectiveness, which makes the professional psychologist a passive subject who is dedicated only to implementing interventions that institutions request. Therefore, EBP demands that the psychologist be critical of the research and this allows the identification of the best evidence available and also must have the skills to adapt that evidence to their particular context. The objective is to characterize the profile of therapists working in 17 outpatient treatment centers in Mexico, as well as the skills related to the use of EBP (sources of consultation and use of manuals, transfer of knowledge to the population and other therapists) and perception of their self-efficacy. Method. This is a cross-sectional research in which 102 therapists participated. Two stages were considered: quantitative, based on the application of a questionnaire, and the second was qualitative, seeking to contrast the responses. Results. Most of the participants had difficulties in explaining EBP, but reported high levels of self-efficacy to implement it. At the beginning of their work, they had no training in addictions or in the clinical area. Discussion. The need for training in EBP from undergraduate studies is addressed so that future therapists will find it more natural to implement it in clinical settings, through the analysis of scientific articles and, if possible, its application.