1.
Org Biomol Chem
; 13(39): 10050-9, 2015 Oct 21.
Artigo
em Inglês
| MEDLINE
| ID: mdl-26299334
RESUMO
Phosphonated derivatives of trifluoromethyl aziridine were obtained with good yield from aziridine-2-carbaldehyde by two distinct methods, which resulted in different diastereoselectivities. Using thiols as nucleophiles ring opening reactions of trifluoromethylated derivatives of aziridine-2-phosphonates proceeded regio- and diastereoselectively, giving rise to γ-amino-γ-trifluoromethyl phosphonates.