Quantification of temporomandibular joint space in patients with juvenile idiopathic arthritis assessed by cone beam computerized tomography.

OBJECTIVE: To describe a method to calculate the total intra-articular volume (inter-osseous space) of the temporomandibular joint (TMJ) determined by cone-beam computed tomography (CBCT). This could be used as a marker of tissue proliferation and different degrees of soft tissue hyperplasia in juvenile idiopathic arthritis (JIA) patients. MATERIALS AND METHODS: Axial single-slice CBCT images of cross-sections of the TMJs of 11 JIA patients and 11 controls were employed. From the top of the glenoid fossa, in the caudal direction, an average of 26 slices were defined in each joint (N = 44). The interosseous space was manually delimited from each slice by using dedicated software that includes a graphic interface. TMJ volumes were calculated by adding the areas measured in each slice. Two volumes were defined: Ve-i and Vi , where Ve-i is the inter-osseous space, volume defined by the borders of the fossa and Vi is the internal volume defined by the condyle. An intra-articular volume filling index (IF) was defined as Ve-i /Vi , which represents the filling of the space. RESULTS: The measured space of the intra-articular volume, corresponding to the intra-articular soft tissue and synovial fluid, was more than twice as large in the JIA group as in the control group. CONCLUSION: The presented method, based on CBCT, is feasible for assessing inter-osseus joint volume of the TMJ and delimits a threshold of intra-articular changes related to intra-articular soft tissue proliferation, based on differences in volumes. Intra-articular soft tissue is found to be enlarged in JIA patients.

Image quality assessment of three cone beam computed tomography scanners-an analysis of the visibility of anatomical landmarks.

BACKGROUND/OBJECTIVES: The aim of this study was to evaluate large field of view (FoV) subjective image quality of three cone-beam computed tomography (CBCT) machines to assess the threshold for reliable diagnostic perceptibility when lowering exposure settings. MATERIALS AND METHODS: One entire cadaver's head was scanned using three CBCT scanners. The largest available FoV of each device, imaging orthodontic relevant structures, was applied. CBCT datasets with different image quality based on standard to minimum scanning parameters were acquired. Five dentists evaluated the visibility of selected anatomical structures of the upper and lower jaw using a 5-point rating scale. RESULTS: Image quality depends on parameters such as a minimum voxel size of 0.2 to 0.4mm or a minimum of 4mA. A reduction in number of images (scanning protocol) reduces image quality. Visualization of different anatomical structures for orthodontic treatment planning requires distinct scanning protocols to support adequate perception of these structures. LIMITATIONS: This study does not account for the evaluation of paediatric anatomical structures due to the availability of cadaver's head. CONCLUSIONS: CBCT scans performed for orthodontic purposes using a large FoV with reduced parameters (400 µm, 2 to 4 mA and low dose protocols) are acceptable for visualization of large anatomical structures. Further lowering these parameters will not be sufficient to view small anatomical structures. Orthodontic indications will have to define specific anatomical structures to choose adequate scanning protocols to reduce dose and ensure reliable diagnostic visibility.

Individualization of the three-piece base arch mechanics according to various periodontal support levels: A finite element analysis.

INTRODUCTION: The orthodontic correction of periodontally compromised dentitions constitutes a huge challenge in the clinical practice of adult orthodontics. The biological and physical distinct features of these conditions require a carefully designed mechanical plan for the successful treatment of these complex cases. SETTING AND SAMPLE POPULATION: A segment of a human maxilla containing the central and lateral incisors, obtained from autopsy, was scanned with microcomputed tomography, and a finite element (FE) model was generated to represent an intact periodontal dentition. Based on this model, three additional models simulating a mild, moderate and severe bone alveolar loss were created as well. MATERIALS AND METHODS: Two loading scenarios for the application of intrusive and retraction mechanics with a three-piece base arch appliance were evaluated in a series of FE analyses. The tooth displacements and strains in the periodontal ligament (PDL) were calculated and compared for the four FE models. RESULTS: The periodontal reduced dentitions exhibited a similar axis of resistance for intrusive mechanics, but the axis of resistance for retraction movements was significantly dependent on the degree of alveolar bone loss. The tooth displacements and PDL loads were higher in the reduced dentitions for both intrusive and retraction mechanics. CONCLUSIONS: A reduction in the force levels applied to periodontal reduced dentitions is indicated, and a customized selection of appropriate points of force application is needed according to the specific amount of alveolar bone loss.

Orthodontically induced root resorption: A critical analysis of finite element studies' input and output.

INTRODUCTION: Orthodontically induced inflammatory root resorption (OIIRR) constitutes an undesirable risk connected to orthodontic treatment. Finite element analysis (FEA) is a powerful tool to study the risk of OIIRR. However, its efficiency in predicting OIIRR depends on the insertion of the correct inputs and the selection of an output coherent with the clinical failure mechanism. METHODS: By combining a systematic review with a 3-dimensional FEA, this article discusses which are the implications of using certain periodontal ligament (PDL) properties (linear and nonlinear models) and failure criteria. Six orthodontic loading regimes were simulated in a maxillary premolar: pure intrusion, buccal tipping, and their combination applied with either a light (25 cN) or a heavy (225 cN) force. Three stress parameters in the PDL were compared: von Mises stress, minimum principal stress, and hydrostatic stress (σH). RESULTS: The comparison between linear and nonlinear models showed notable differences in stress distribution patterns and magnitudes. For the nonlinear PDL, none of the light-force models reached the critical compressive hydrostatic stress of 4.7 kPa, whereas all the heavy-force models reached it. In addition, the regions of critical compressive σH matched with the regions with resorption craters in clinical studies. In linear models, the σH critical value of 4.7 kPa was reached even in the light-force scenario. CONCLUSIONS: Only compressive hydrostatic stress in PDL satisfied the requirements to be used as an FEA indicator of OIIRR. However, the requirements were satisfied only when a nonlinear PDL model was considered.

In vitro comparison of the torsional load transfer of various commercially available stainless-steel wires used for fixed retainers in orthodontics.

OBJECTIVE: To assess the torsional load transfer of various commercially available stainless-steel wires used for fixed retainers. DESIGN: An in vitro study using a robotic device. SETTING: Department of Pediatric Oral Health and Orthodontics, University of Basel. METHODS: A 10° proclination of a maxillary lateral incisor of a 2-2 retainer was simulated with a robotic device. Eight stainless-steel wires with different shapes (round or rectangular), types (plain, braided, coaxial or chain) and dimensions were selected to measure the torsional load transfer at the adjacent central incisor. The influence of annealing was also tested. RESULTS: The 0.016 × 0.016 and Bond-A-Braid™ wires (0.02645 × 0.01055-inch, 8-stranded, braided) showed the largest relative torsional load transfer (3.7% and 3.3%, respectively). The two multistranded wires - Triple Flex™ and Respond® - showed the smallest values of 1.0% and 0.7%, respectively. The spiral direction of these two multistranded wires affected the load transfer, the twisting showing larger torsional load transfer than the untwisting one. CONCLUSION: The effective torsional load transfer depends on the dimension, shape and type of a wire. Plain and braided retainers were more predictable in torsional load transfer than multistranded retainers, which may have stored more energy in the area between the composite bonding sites. This may explain the unexpected complications reported in multistranded retainers.

The biomechanical evaluation of magnetic forces to drive osteogenesis in newborn's with cleft lip and palate.

This study examined the potential for dental magnets to act as a driving force for osteogenesis in the palate of newborns with a unilateral cleft lip and palate. In the first part of the study dental magnets were arranged in a set up mimicking a distraction device and the curves of the magnetic attraction force versus gap distance curves generated, with and without the presence of palatal rugae tissue in between both sides of the distraction device. The attraction forces ranged from 1 to 12 N depending on the gap distance and the presence of soft tissue in the gap. In the second part of the study these forces were used as input for a 3D finite element model of the palate of a newborn affected by unilateral cleft lip and palate. In the analysis of load transfer, it was found that the strains generated by a magnetically induced distraction exceed 1,500 µstrain suggesting that bone locally is submitted to mild overload leading to bone apposition.

Condylar changes in patients with idiopathic condylar resorption: retrospective 2-year follow-up CBCT-based case-control study.

OBJECTIVES: To compare condylar development and changes in condylar radiological appearance in patients with idiopathic condylar resorption (ICR) to a healthy, age- and gender matched, control group. MATERIALS AND METHODS: This case-control study included 16 ICR patients [mean age: 15years, 9 months; standard deviation (SD): 4 years) and 16 controls (mean age: 16 years, 8 months; SD: 4 years, 7 months), with diagnostic (T0) and 2-year follow-up (T1) CBCT examinations. Condylar changes were evaluated through changes in condylar neck angle (CNA), and the transversal, vertical and anteroposterior displacement of five condylar points between T0 and T1. The magnitude and direction of condylar changes were evaluated using vector analyses. A qualitative radiological evaluation of the TMJ was performed based on healthy, erosive and repaired morphological appearance. Linear and angular measurements were assessed using ANOVA and a Tukey post-hoc test, and vectors were tested using an independent-sample 2-tailed t-test. Fisher's exact test was used for the qualitative evaluation. RESULTS: At T0, ICR patients exhibited decreased condylar height, smaller condylar width and posteriorly inclined CNA compared with the control group (P < 0.05). During observation, condylar vertical growth was smaller in the ICR group than in the control group (P < 0.05). Vector analysis showed an upward direction of vertical displacement for all condylar points in the control group; the ICR group showed a downward direction (P < 0.003). The radiological appearance of 75% of the ICR condyles and 94% of the control condyles did not change during the 2-year follow-up period. CONCLUSIONS: ICR condyles displayed reduced vertical development compared with control condyles. The radiological appearance remained unchanged for most joints. Observed changes in radiological appearance did not always follow a progressive model of degenerative joint disease.

Palatal morphology in unilateral cleft lip and palate patients: Association with infant cleft dimensions and timing of hard palate repair.

OBJECTIVES: To assess the impact of cleft severity and timing of hard palate repair on palatal dimensions in unilateral cleft lip and palate (UCLP) children. SETTING AND SAMPLE POPULATION: Single-centre analysis within a multicenter RCT of primary surgery; 122 UCLP randomized to early hard palate closure (EHPC) at 12 months or delayed hard palate closure (DHPC) at 36 months; 28 frequency-matched controls. METHODS: Linear measurements of palatal height, width and length were performed on 116 digital models of UCLP subjects (8.21 years, SD = 0.53) and 28 models of non-cleft individuals (8.44 years SD = 0.72). Cleft dimensions at infancy (mean 1.8 months) were considered. In a pilot study, shell-to-shell distances between the 3D cleft palate objects and a reference mesh were calculated and differences between the groups assessed. Morphological differences were visualized using colour mapping. RESULTS: Compared to controls, UCLP subjects presented a higher palate at the level of the anterior scar (P = 0.002), but generally a lower palate in the middle region (P < 0.001). Comparing UCLP subgroups, the DHPC subjects showed a flatter palate posteriorly (P = 0.048) and the EHPC group exhibited more transversal constriction (P = 0.003 at M1 level). 3D analysis revealed a shallower palate in the DHPC group both in the middle (P = 0.002) and the posterior part (P = 0.008). Anterior cleft severity correlated negatively with palatal height (P = 0.01). CONCLUSIONS: Unilateral cleft lip and palate palates differ from controls in width and height. DHPC may represent an advantage for the transversal dimension, but a disadvantage for palatal height. Infant cleft dimensions partially explain differences in palatal height.

Calcium phosphate precipitation in experimental gaps between fluoride-containing fast-setting calcium silicate cement and dentin.

A novel fast-setting calcium silicate cement containing fluoride (novel-CSC) has been developed for applications in tooth crowns. The aim of this study was to assess the ability of the novel-CSC to close the experimental gaps at the dentin-cement interface. The novel-CSC was tested against Vitrebond and GC Fuji II LC. Experimental gaps of 50 or 300 µm width were created between the materials and dentin. Specimens with the 300-µm-wide gap were immersed in phosphate-buffered saline and the closed gap area was measured during 96 h. All specimens with 50 or 300 µm gap width were analyzed by scanning electron microscopy equipped with energy dispersive X-ray spectroscopy (SEM/EDX) to assess the morphology and chemical composition of the precipitates after 96 h immersion in phosphate-buffered saline. High-resolution micro-computed tomography (µCT) was used to evaluate the integrity and continuity of the precipitiates after 96 h and 180 d. In all novel-CSC samples, precipitates closed the gap area completely after 96 h. The SEM/EDX revealed that the globular precipitates closing the gap area were mainly composed of calcium and phosphorus. After 180 d, µCT indicated thicker precipitates compared with initial precipitates only in the novel-CSC group, whereas no precipitates were observed in resin-modified glass ionomers. Novel-CSC promoted continuous precipitation of calcium phosphate, including apatite, and closed the experimental gaps.

Evaluation of facial asymmetry in patients with juvenile idiopathic arthritis: Correlation between hard tissue and soft tissue landmarks.

INTRODUCTION: The aims of this study were to assess the correlation between facial hard and soft tissue asymmetry in patients with juvenile idiopathic arthritis, to identify valid soft tissue points for clinical examination, and to assess the smallest clinically detectable level of dentofacial asymmetry. METHODS: Full-face cone-beam computed tomography scans and 3-dimensional photographs were used to assess facial hard and soft tissue asymmetry in 21 patients with juvenile idiopathic arthritis. A survey was conducted to assess how asymmetry is perceived observationally based on cone-beam computed tomography scans and 3-dimensional photographs. RESULTS: Significant linear correlations were seen between the hard and soft tissue landmark deviations at both the transverse and vertical positions. Among medial soft tissue points, glabella had the smallest deviation and pogonion the largest deviation from the midsagittal plane. Professionals could identify facial asymmetry based on images beyond a cutoff threshold of 2 mm for both pogonion and gonion. CONCLUSIONS: Soft tissue pogonion and gonion were identified as the most appropriate landmarks to clinically predict hard tissue facial asymmetry. Facial asymmetries are most pronounced in the lower facial third in patients with juvenile idiopathic arthritis. Professionals can accurately identify asymmetry exceeding 2 mm.

Corticotomy affects both the modus and magnitude of orthodontic tooth movement.

Objective: To analyze whether the decreased bone density due to the manipulation of bone remodeling rate has an influence on the type of the planned tooth movement. Materials and methods: A finite element model of a lower incisor has been developed. The density of the alveolar bone surrounding the tooth has been assumed to simulate the one occurring after corticotomy to increase tooth movement rate. Moment-to-force ratios corresponding to three different types of movements have been simulated; uncontrolled tipping, translation, and root movement. The three tooth movements have been analyzed in both corticotomized and non-corticotomized simulations, and the final effects on the amount and type of tooth movement analyzed. The stress and strain levels in the periodontal ligament have been analyzed too. Results: The amount of tooth movement obtained in case of lower bone density is higher in all types of movement simulations. The centre of rotation of the movement shifts more apically in case of translation, controlled and uncontrolled tipping. In the corticotomy simulations, the compressive stresses in the periodontal ligament decreased while the tensile stresses increased. Conclusion: A decreased bone density influences not only the amount of tooth movement, but also its type. This study suggests that the moment-to-force ratios used in conventional orthodontics should be modified in case of techniques that decrease bone density to enhance tooth movement rate.

Torque resistance of different stainless steel wires commonly used for fixed retainers in orthodontics.

OBJECTIVE: Movements of teeth splinted by fixed retention wires after orthodontic treatment have been observed. The aetiological factors for these movements are unknown. The aim of this in vitro study was to compare the resistance to torque of different stainless steel wires commonly used for fixed retainers in orthodontics. MATERIALS AND METHODS: Torquing moments acting on a retainer wire were measured in a mechanical force testing system by applying buccal crown torque to an upper lateral incisor in both a 3-teeth and in a 2-teeth setup. Seven stainless steel wires with different shape, type (plain, braided, coaxial, or chain) and dimensions were selected for this study. RESULTS: For a torquing angle of 16.2° in the 3-teeth setup torsion moments can vary between 390 cNmm and 3299 cNmm depending on the retainer wire. For the 2-teeth setup the torsion moments are much smaller. Exposure to the flame of a butane-gas torch for 10 seconds to anneal the wire reduces the stiffness of the retainer wire. CONCLUSIONS: Clinicians must select wires for fixed retainers very carefully since the difference in resistance to torque is large. A high level of torque control can be achieved with a plain 0.016 × 0.016-inch or a braided 0.016 × 0.022-inch stainless steel wire. A tooth attached by a retainer wire to only one neighbouring tooth is less resistant to torque than a tooth connected to two neighbouring teeth. Annealing a retainer wire with a flame reduces the stiffness of the wire markedly and can lead to a non-uniform and non-reproducible effect.

Actual versus theoretical torsional play in conventional and self-ligating bracket systems.

OBJECTIVE: The aim of this study was to assess the amount of torsional play in 32 commercially available self-ligating and conventional 0·018-inch and 0·022-inch bracket systems in relation to 0·017×0·022-inch and 0·019×0·025-inch stainless steel wires, respectively, and compare the results with the theoretical amount of play for the given bracket/wire combinations. METHODS: Torque moments were measured in a mechanical force testing system by twisting straight pieces of stainless steel wire seated in the bracket slot in increments of 0·5° until a full torsional expression was registered. Five upper central incisor brackets from each of the 32 different bracket systems were selected for the study. RESULTS: The result from the laboratory testing clearly showed that wire/slot play was larger than anticipated from the nominal values, especially regarding the 0·022-inch brackets and particularly in relation to the passive self-ligating brackets. The play ranged from 19·8 to 36·1° of play for the most imprecise bracket system. CONCLUSIONS: The result does not favour the use of self-ligating brackets when focussing on torque control. The actual play is larger due to oversized slots and the inability of self-ligation brackets to press the archwire into the bottom of the slot. In conventional brackets, the initial torque moment is generated by the steel ligatures pressing the arch wire against the bottom of the slot. The oversize of the slot is thus less critical in relation to the conventional than in relation to the passive self-ligation bracket.

Three-dimensional analysis of the pulp cavity on surface models of molar teeth, using X-ray micro-computed tomography.

AIM: The purpose of this study was to investigate the scanning and segmentation precision of surface models of molars for the detection of small volumes, such as the reduced pulp cavity; formation of mineral deposits; detection of narrow root canals and to improve the clinical and morphological understanding of the number of root canals and their configuration. METHODS: Eighteen human molars were scanned using X-ray micro-computed tomography. The reconstruction of the surface models had a precision of <1 voxel, using three-dimensional software and quantitative color mapping. In order to relate the measurements to changes over time the size of the pulp chambers was classified in two well-defined groups. RESULTS: The mineral deposits were more evenly distributed in small pulp chambers than in large, but complete root canal calcification was never observed. No difference was observed in the material with respect to the presence of intra-radicular connections. In upper molars, a second mesiobuccal canal (mb(2)) frequency of 91% was found. The difference in length between the first mesiobuccal canal (mb(1)) and mb(2) was <1 mm. The number of root canals could be related to the number of root cones. CONCLUSION: In summary, three-dimensional surface models were made with a high precision; an increased accumulation of mineral deposits was noted in molars with small pulp chambers and combined with the consistent pattern of intra-radicular connections, the potential endodontic treatment complexity is underlined in such cases. Finally, an improved understanding of root canal prevalence was reached, when merging well-defined definitions on root morphology and clinical classification systems.

The Effect of Symmetric and Asymmetric Loading of Frontal Segment with Two Curved Cantilevers: An In Vitro Study.

Cantilevers generate statically determined force systems. The frontal segment loading with symmetric and asymmetric cantilevers in a three-piece intrusion base arch can be used to correct midline asymmetry. Three types of 0.017″ × 0.025″ beta-titanium cantilevers: tip-back (TB), deep curve (DC), utility arch (UA) were tested on typodonts simulating intrusion of the maxillary anterior segment. Typodonts with symmetric and asymmetric cantilevers were scanned with intraoral scanner (3Shape, TRIOS, Copenhagen, Denmark) before (T0) and after (T1) the experiment, scans were superimposed using Mimics software (Materialise, Leuven, Belgium). Data were analysed with qualitative analysis. All cantilevers generated vertical and horizontal forces. For symmetric design, the DC and TB displayed intrusive force with retrusive component, UA intrusion and protrusion. The asymmetric cantilevers produced transverse displacement of anterior segment. DC created lateral, UA medial force, the anterior segment displacement was consistent with the used configuration. The movement of an anterior segment with TB is smaller compared to DC and UA. Symmetric cantilevers configurations can achieve simultaneous intrusion and retrusion or protrusion of the anterior segment. The asymmetric design with transversal force can clinically aid the correction of midline discrepancies. The effect of the cantilever configuration on delivered force direction was confirmed.

Force Systems Produced by Different Cantilever Configurations during Deactivation.

Intrusion with a three-piece arch is routinely achieved during orthodontic treatment. This study aimed to experimentally determine how the cantilever design influences the generated force system. Both straight and arch-formed cantilever designs: tip-back (TB), flat curve (FC) deep curve (DC), and 3 mm and 6 mm high utility arch (UA3; UA6) were activated for 5 mm and 10 mm. Force systems were determined by a hexapod. Typodonts simulating a three piece-intrusion arch were scanned using an intraoral scanner (3Shape, TRIOS, Denmark) before (T0) and after (T1) the experiment and superimposed with Mimics software (Materialise, Leuven, Belgium). Data were analyzed. All straight designs displayed an extrusive force in the vertical plane, and all arch-formed an intrusive force. DC and TB showed a retrusive force in the sagittal plane and UA6 a protrusive. For the medial/lateral forces, DC and TB displayed a medial, and UA6 a lateral force. Configurations can be distinctively ranked from DC, FC, TB to UA3, and UA6 according to the increasing protrusive nature of the generated sagittal forces. A DC or TB configuration should be used for intrusion and retraction, while for an intrusion and a protrusion, a UA6 configuration. All straight configurations showed a higher force level than the arch-formed configurations.

Cantilevers: Multi-Tool in Orthodontic Treatment.

This review aims to discuss and illustrate various uses of cantilevers to solve multiple clinical issues and prove their versatility. Cantilevers are commonly used in the segmented arch technique, and they can be designed to solve various clinical problems with highly predictable results. Its design and shape can modify the various combinations of vertical and horizontal forces. The novel trend is to combine cantilevers with skeletal anchorage. Cantilevers offer a very simple and statically determined force system. The advantage is the control over side effects, which normally occur on the anchor teeth and the occlusion. The disadvantages include possible side effects on the anchorage unit, when the anchorage is poorly controlled. The review highlights the clear benefits of cantilever use in complex corrections of single teeth, segments, and entire arch with a diminished effect on the dentition, also with the use of skeletal anchorage. With their simple and easily tailored design, these springs can be called an orthodontic multi-tool.

In Vitro Comparison of Different Invisalign® and 3Shape® Attachment Shapes to Control Premolar Rotation.

Aim: To evaluate in vitro the differences of various Invisalign® attachments in their effectiveness during derotation of an upper second premolar in terms of forces and moments created and compare them to the 3Shape® box attachment as well as to no attachment at all. Materials and Methods: A Force System Identification (FSI) machine, comprising two load sensors, was used in this study. Sensor 1 was connected to the test tooth (i.e. upper second premolar) carrying a different attachment design, and the fixed sensor (Sensor 2) was connected to the base model. Once the corresponding aligner was passively seated on the teeth, 12 different setups (i.e. 11 different attachments and one setup with no attachment at all) were tested by rotating the test tooth 4.5° mesially and 4.5° distally, in increments of 0.45°. Results: The vertical rectangular attachments were able to generate the highest derotational moment on both mesial and distal rotations but also received the most side effects (intrusive force, torque, and tipping). The no-attachment setup performed least favorably in terms of derotational ability but exhibited the least side effects. In the y-axis, all attachments received a buccal root torque with a lingual force during disto-rotation and a lingual root torque with a buccal force during mesio-rotation. Conclusion: Attachments are necessary for derotating an upper second premolar. An aligner incremental change of more than 1° derotation can generate high moments. The vertical rectangular attachments perform best in derotations; however, they exhibit the most side effects. Finally, despite presenting the least side effects, derotation of a premolar with no attachment is not as efficient.

The Effect of Ligature Type on Lateral Tooth Movement during Orthodontic Treatment with Lingual Appliances-An In Vitro Study.

(1) Background: One of the most challenging parts in lingual orthodontics is the control and correction of the tip of anterior teeth, due to the occlusal open vertical slot of the incisors in lingual systems. The presented experimental in-vitro study was performed to determine the maximal tipping moment of the anterior teeth between two types of lingual brackets, the Incognito™ Appliance System (Incognito, TOP-Service, Bad Essen, Germany) and Tip-Bar™ system (Incognito, TOP-Service, Bad Essen, Germany). Furthermore, twelve different ligation methods and two different ligature materials were investigated. (2) Methods: The measurement was performed by assessing the stiffness and ultimate strength of the ligature in a uniaxial material testing machine (Instron, Norwood, MA, USA) using a 0.025 × 0.018 inch stainless steel wire. (3) The results showed that the highest precision for control tipping of anterior teeth was determined for the 0.010 inch Stainless Steel Tie (Pelz and Partner). Furthermore, the Tip-Bar™ brackets increased the maximal moment by 33.8% for elastic and steel ligatures. (4) Conclusions: The lateral tooth movement is highly dependent on the type of ligature and applied material during orthodontic treatment with lingual appliances. The use of 0.010 inch steel ligatures and the Tip-Bar™ bracket design results in better alignment in the anterior teeth segment.

Association between condylar morphology and changes in bony microstructure and sub-synovial inflammation in experimental temporomandibular joint arthritis.

BACKGROUND: In juvenile idiopathic arthritis involvement of the temporomandibular joints (TMJs) is often associated with mandibular growth deviations. The relation between the growth deviations and severity of the inflammation, condylar shape, the micro-architecture, and the quality of the bone has not previously been investigated. This paper studies the effect on the bony structures in mandibular condylar development in rabbits with antigen-induced arthritis. METHODS: Included were 42 juvenile rabbits with ovalbumin-induced arthritis of the TMJs treated with intraarticular saline, intraarticular etanercept or subcutaneous etanercept. A TMJ from each animal was scanned using micro-computed tomography and structural parameters were calculated. Three-dimensional reconstructions of the mandibular condyle were scored blindly as normal or abnormal. TMJs were stratified for condylar morphology and were evaluated against data on trabecular structural parameters, inflammation, degree of mineralization, overall mandibular growth, and mineral apposition rate. RESULTS: Abnormal morphology were seen in 15/32 animals available for data analysis. Erosions were an uncommon finding. Abnormal morphology was strongly related to the degree of inflammation. The trabecular separation was larger in group with abnormal morphology than in the group with normal morphology. Abnormal condylar morphology was not associated with overall mandibular growth. No differences were observed in mineral apposition rate. No differences in structural parameters were seen according to treatment modality. CONCLUSION: We showed that severe inflammation in the TMJs during mandibular development was associated with morphological changes in the mandibular condyle. These changes were predominantly seen at the macro-morphological level and only very few differences were structural.