RESUMO
This prospective six-year longitudinal study reviews the clinical outcome of patients undergoing autologous chondrocyte implantation (ACI) and a porcine type I/III collagen membrane cover for deep chondral defects of the knee. We present 57 patients (31 male, 26 female) with a mean age of 31.6 years (range 15-51 years) that have undergone ACI since July 1998. The mean size of the defect was 3.14 cm(2) (range 1.0-7.0 cm(2)). All patients were assessed annually using seven independent validated clinical rating scores with the data analysed using ANOVA. ACI using a porcine type I/III collagen membrane cover produced statistically significant improvements (p < 0.001), maintained for up to six years, in knee symptoms compared to pre-operative levels. This study provides evidence of the medium-term benefit achieved by transplanting autologous chondrocytes to osteochondral defects.
Assuntos
Bioprótese , Cartilagem Articular/cirurgia , Condrócitos/transplante , Traumatismos do Joelho/cirurgia , Articulação do Joelho/cirurgia , Prótese do Joelho , Adolescente , Adulto , Animais , Artroscopia , Cartilagem Articular/lesões , Cartilagem Articular/patologia , Transplante de Células/métodos , Condrócitos/patologia , Colágeno Tipo I/uso terapêutico , Colágeno Tipo III/uso terapêutico , Feminino , Humanos , Traumatismos do Joelho/patologia , Traumatismos do Joelho/reabilitação , Articulação do Joelho/patologia , Articulação do Joelho/fisiopatologia , Masculino , Pessoa de Meia-Idade , Estudos Prospectivos , Recuperação de Função Fisiológica , Suínos , Transplante Autólogo , Resultado do Tratamento , Adulto JovemRESUMO
BACKGROUND: Myxoid liposarcoma is the second most commonly occurring sub-type of liposarcomas. In contrast to other soft tissue sarcomas, it is known to have a tendency to spread toward extrapulmonary sites, such as soft tissues, retroperitoneum, and the peritoneal surface. Bony spread, however, is not as common. CASE PRESENTATION: We report an unusual case of diffuse skeletal metastases from myxoid liposarcoma occurring 13 years after treatment of the primary tumour in the left lower limb. The skeletal spread of the disease was demonstrated on MRI only after other imaging modalities (plain radiography, CT and TC99 bone scans) had failed to detect these metastases. CONCLUSION: MRI is an extremely sensitive and specific screening tool in the detection of skeletal involvement in these types of sarcomas, and therefore, should be a part of the staging process.