Diagnosis and management of acquired aplastic anemia in childhood. Guidelines from the Marrow Failure Study Group of the Pediatric Haemato-Oncology Italian Association (AIEOP).

Acquired aplastic anemia (AA) is a rare heterogeneous disorder characterized by pancytopenia and hypoplastic bone marrow. The incidence is 2-3 per million population per year in the Western world, but 3 times higher in East Asia. Survival in severe aplastic anemia (SAA) has improved significantly due to advances in hematopoietic stem cell transplantation (HSCT), immunosuppressive therapy, biologic agents, and supportive care. In SAA, HSCT from a matched sibling donor (MSD) is the first-line treatment. If a MSD is not available, options include immunosuppressive therapy (IST), matched unrelated donor, or haploidentical HSCT. The purpose of this guideline is to provide health care professionals with clear guidance on the diagnosis and management of pediatric patients with AA. A preliminary evidence-based document prepared by a group of pediatric hematologists of the Bone Marrow Failure Study Group of the Italian Association of Pediatric Hemato-Oncology (AIEOP) was discussed, modified and approved during a series of consensus conferences that started online during COVID 19 and continued in the following years, according to procedures previously validated by the AIEOP Board of Directors.

[Effects of ketanserin on glucose metabolism in hypertensive diabetic subjects]. / Studi degli effetti della ketanserina sul metabolismo glicidico in soggetti diabetici ipertesi.

In this report the Authors have verified the effects of Ketanserin on glycaemic metabolism of type II diabetic subjects with a moderately high blood pressure. They think that a therapeutic dose of drug is not able to considerably inhibit insulin production. The Authors can assert that the Ketanserin does not influence the glycaemic regulation by therapeutic dose, neither does it increase the diabetic disease, nor disturb the oral hypoglycaemic therapy though it normalizes high blood pressure.

[Effects of pentobarbital on serum levels of LH and FSH, in normal conditions and after GnRH stimulation: preliminary report]. / Effetti del pentobarbital sui livelli sierici di LH ed FSH, nell'uomo, in condizioni basali e dopo stimolo con GnRH: nota preliminare.

The authors have tested serum levels of LH and FSH in healthy males anaesthetized with 20 mg/Kg body weight of pentobarbital, and stimulation test with GnRH. LH has reached levels higher than the stimulation test has been practised in the anaesthetized volunteers than in subjects awakes. The AA. have also showed that there is no effect on psychic stress and of atropine, used as preanaesthetic drug, on serum levels of the pituitary hormones. At the end, PB has no effect on serum levels of FSH.

[Inhibitory effects of atropine on serum prolactin levels after TRH stimulation]. / Effetto inibente dell'atropina sui livelli sierici di prolattina dopo stimolo con TRH.

The authors have tested serum levels of PRL after administration of atropine 10' and 60' before stimulation test with TRH, in 12 male and 12 female. The administration of the drug 10' before TRH has inhibited the PRL release, in all the groups. No effect presented atropine if administered 60' before TRH test.

[Effect of atropine on hypophyseal gonadotropins in the basal condition and under GnRH stimulation]. / Azione dell'atropina sulle gonadotropine ipofisarie in condizioni basali e dopo stimolo con GnRH.

The Authors have tested serum levels of LH and FSH in 10 healthy males after stimulation test with GnRH preceded by administration i.m. of 1 mg. of atropine 10' and 1 hour before the test, to examine some interferences of the drug on ipophisary gonadotropins. Atropine has no effect on LH and FSH release because there are no differences between mean values of the hormones during the test with and without atropine, at any time it is administered. All the data obtained have been controlled with Student's "t" test.

[Effects of pentobarbital on serum PRL and TSH in the basal condition and under TRH stimulation in man: preliminary note]. / Effetti del pentobarbital sui livelli sierici di PRL e TSH in condizioni basali e dopo stimolo con TRH nell'uomo: nota preliminare.

The Authors have tested serum levels of PRL and TSH in six healthy males, anaesthesized with 20 mg./Kg. body weight of pentobarbital with and without stimultion with TRH. PB has no effect on serum levels of TSH but there is an inhibition of PRL release 180', 240' and 360' after the administration of the drug. The AA. have found no effects of PB on the stimulation test with TRH. All the data obtained have been examined with Student's "T" test.

[Evaluation of the effect of picotamide on platelet function in diabetic subjects]. / Valutazione degli effetti della picotamide sulla funzione piastrinica in soggetti diabetici.

In this study the Authors verify the results of Picotamide on platelet aggregation in diabetic subjects. The results suggest that Picotamide has no influence on insulin or oral treatment of diabetic subjects. However, it is certain that platelet aggregation by ADP or collagen decreases due to the effect on thromboxane probably because of the limitation of platelet receptors.