1.
Org Process Res Dev
; 25(12): 2806-2815, 2021 Dec 17.
Artigo
em Inglês
| MEDLINE
| ID: mdl-35095257
RESUMO
Herein is described the development of a large-scale manufacturing process for molnupiravir, an orally dosed antiviral that was recently demonstrated to be efficacious for the treatment of patients with COVID-19. The yield, robustness, and efficiency of each of the five steps were improved, ultimately culminating in a 1.6-fold improvement in overall yield and a dramatic increase in the overall throughput compared to the baseline process.