Clinical outcomes and patient satisfaction following total joint replacement in haemophilia--23-year experience in knees, hips and elbows.

Joint replacement surgery is an available option for end-stage haemophilic arthropathy. However, reports with long-term follow-up are limited. Moreover, patient satisfaction in this setting has never been measured. We share our institution's experience with joint arthroplasty in haemophilic arthropathy and report on clinical outcomes and patient satisfaction. Between 1985 and 2007, 65 consecutive joints in 45 patients (mean age: 48.6; range: 22-83) underwent joint replacement surgery. Of these, 40 total knee replacements in 31 patients, 18 total hip replacements in 16 patients and 6 total elbow replacements in 3 patients were included. Average follow-up was 10.7 years (2.4-24.3). Charts were reviewed retrospectively and patients were asked to return for clinical assessment and completion of questionnaires. According to the Knee Society clinical score, postoperative results were good to excellent in 83% of knees. According to the Harris Hip Score, results were good to excellent in 31% of hips. According to the Mayo Elbow Performance Score, results were good to excellent in 83% of elbows. Complication rates are higher than in the non-haemophilic population, while prosthesis survival rates are lower. Patient satisfaction with pain relief is higher than satisfaction with functional improvement. For 88% of joints, patients are willing to have the same operation again. This study confirms previous knowledge on the role of total joint arthroplasty in haemophilic arthropathy. Despite high complication rates and modest functional outcomes, the operations are valuable for achieving pain relief. In general, patients find that risks are outweighed by the benefits.

Does the disabilities of the arm, shoulder and hand (DASH) scoring system only measure disability due to injuries to the upper limb?

Although the Disabilities of the Arm, Shoulder and Hand (DASH) questionnaire was designed, and has been validated, as a measure of disability in patients with disorders of the upper limb, the influence of those of the lower limb on disability as measured by the DASH score has not been assessed. The aim of this study was to investigate whether it exclusively measures disability associated with injuries to the upper limb. The Short Musculoskeletal Functional Assessment, a general musculoskeletal assessment instrument, was also completed by participants. Disability was compared in 206 participants, 84 with an injury to the upper limb, 73 with injury to the lower limb and 49 controls. We found that the DASH score also measured disability in patients with injuries to the lower limb. Care must therefore be taken when attributing disability measured by the DASH score to injuries of the upper limb when problems are also present in the lower limb. Its inability to discriminate clearly between disability due to problems at these separate sites must be taken into account when using this instrument in clinical practice or research.

Methodology of the Cardiovascular Health and Age-Related Maculopathy (CHARM) Study.

Age-related macular degeneration (AMD) is responsible for the majority of visual impairment in the Western world. Epidemiological studies examining risk factors for AMD are needed to develop strategies for the prevention of blindness from this condition. A number of potentially modifiable risk factors for AMD have been identified; however, only smoking has been a consistent risk factor across the numerous studies. A growing body of evidence suggests that AMD and cardiovascular disease may have common risk factors. The Cardiovascular Health and Age Related Maculopathy (CHARM) Study was established to examine the risk factors for AMD and its progression, in particular risk factors associated with cardiovascular disease. Examining risk factors for prevalent AMD, cases with AMD were compared with age and gender matched controls with no AMD features. For the assessment of AMD progression, the study examined in 2001 and 2002 those participants with early AMD, or age-related maculopathy (ARM), who had undergone baseline examination between 1992 and 1995 and compared the characteristics of those who had progression of AMD with those who did not. The CHARM study involved both ophthalmic and cardiovascular examinations. Standardised clinical eye examination and grading of the macular stereo photographs were used to determine the AMD status and progression. To examine cardiovascular status, carotid artery ultrasound imaging analysis of systemic arterial compliance, augmentation index and pulse wave velocity were performed. The traditional and novel risk factors for CVD such as levels of glucose, cholesterol, high density lipoprotein cholesterol, low density lipoprotein cholesterol, fibrinogen, C-reactive protein, immunoglobulins A and M, homocysteine, oxidized LDL and the exposure to the Chlamydia Pneumonia infection were determined. DNA was collected for apolipoprotein E genotyping. The present paper outlines the primary aims of the CHARM study, the methodology involved and the recruitment results.

Outcomes of isolated tibial shaft fractures treated at level 1 trauma centres.

BACKGROUND: Although most tibial shaft fractures are expected to heal within 24 weeks, the long-term effects of these injuries on patients in terms of self-reported health status, disability, and pain are largely unknown. OBJECTIVES: To investigate the clinical and patient-reported outcomes of patients with isolated tibial shaft fractures treated at the two level 1 adult trauma centres in Victoria, Australia. METHODS: Sixty patients with isolated tibial shaft fractures treated at the Royal Melbourne Hospital and the Alfred Hospital between August 2003 and August 2004 were identified via the Victorian Orthopaedic Trauma Outcomes Registry (VOTOR). Patient-reported outcomes were prospectively measured 1 year post-injury using the 12-Item Short-Form Health Survey (SF-12) (also administered at baseline); the Work subscale of the Sickness Impact Profile; and a Numerical Rating Scale for pain. A priori defined clinical outcomes were also determined by retrospectively reviewing hospital medical records and X-rays. RESULTS: Full weight-bearing status was achieved after a median inter quartile range (IQR) time of 14.0 (12.5-20.0) weeks, and the median (IQR) time to radiological union was 35.8 (23.3-51.6) weeks. Sixty percent of patients completed the SF-12 at both baseline and 12 months post-injury. Although there were no clear changes in mental health scores (median change=+1.0; IQR=-3.5 to 4.0; p=0.52), physical health scores were significantly reduced (median change=-3.0; IQR=-19.5 to 0.3; p=0.003). Additionally, 47% of patients reported work-related disability and 40% experienced persistent pain 1 year post-injury. CONCLUSIONS: These results indicate that long-term physical disability remains a problem for many patients following tibial shaft fracture, and they should be considered when providing prognostic information to patients. Further research is required to identify the specific health problems experienced as well as the factors contributing to disability in order to inform post-fracture rehabilitation planning.