Assuntos
Doenças do Colágeno/diagnóstico , Doença de Hodgkin/complicações , Dermatopatias/diagnóstico , Transtornos de Adaptação/etiologia , Adulto , Antineoplásicos/administração & dosagem , Antineoplásicos/uso terapêutico , Doenças do Colágeno/etiologia , Doenças do Colágeno/patologia , Feminino , Doença de Hodgkin/tratamento farmacológico , Doença de Hodgkin/patologia , Humanos , Estadiamento de Neoplasias , Prurido/diagnóstico , Prurido/etiologia , Dermatopatias/patologia , Resultado do TratamentoRESUMO
Gastrointestinal stromal tumors (GIST) appear in the abdominal cavity in less than 5% of patients. We present two cases of extraintestinal GIST attended in our service and treated with imatinib mesylate. We review the current treatment of these neoplasms with targeted therapies.
Assuntos
Tumores do Estroma Gastrointestinal/patologia , Pelve/patologia , Adulto , Idoso , Feminino , Tumores do Estroma Gastrointestinal/diagnóstico por imagem , Tumores do Estroma Gastrointestinal/cirurgia , Humanos , Laparotomia , Pelve/diagnóstico por imagem , Pelve/cirurgia , Tomografia Computadorizada por Raios X , Resultado do TratamentoRESUMO
POEMS syndrome is a rare multisystemic disorder characterized by polyneuropathy (P), organomegaly (O), endocrinopathy (E), blood dyscrasia with M-protein band (M), and skin changes (S). The pathogenesis of POEMS syndrome is not completely understood. This paraneoplastic syndrome may be associated to bone lesions that are characteristically sclerotic or lytic with sclerotic halo and negative at bone scintigraphy. We report a case of a 37-year-old man with several manifestations of POEMS syndrome who presented bone lesions characteristic of osteosclerotic myeloma confirmed by bone biopsy.