Cardiovascular effects induced by progesterone administration.

The Authors have studied cardiovascular effects induced by progesterone administration. The results obtained in the present investigation reveal a significant reduction in O-S2 and PEP in the absence of modifications in the values of the other parameters of systolic time intervals. The results confirm the hypothesis that progesterone exerts an adrenergic effect upon cardiac function.

[Pharmacovigilance: theoretical and practical aspects]. / La farmacosorveglianza: aspetti teorici e pratici.

Pharmacovigilance is reviewed as requirement for monitoring of drug safety. The authors examine the most important theoretic pictures of postmarketing surveillance of drugs.

[Drug-induced lung diseases]. / Pneumopatie da farmaci.

In the light of recent fresh reports of drug-induced lung lesions, the authors suggest an updated classification of these based on data found in the literature. Special attention has been reserved to the pathogenetic mechanisms underlying specific clinical pictures.

[Tolerability and side effects of interferon alpha in the treatment of chronic viral hepatitis]. / Tollerabilità ed effetti collaterali dell'interferone alfa nel trattamento delle epatiti croniche virali.

It is reported a review on side effects and toxicity of alfa interferon in treatment of chronic viral hepatitis. The clinical experience in 44 patients affected by chronic hepatitis and treated with 3MU of alfa interferon is analysed.

[Drug-induced hepatobiliary damage]. / Danni epato-biliari da farmaci.

Setting out from the high prevalence of iatrogenic toxic effects on the liver and biliary system, the authors examine the pathophysiological mechanisms underlying and suggest an updated classification. The clinical models of the action of main drugs responsible are discussed.